Compounds > blestriarene c

Page last updated: 2024-11-12

blestriarene c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

blestriarene C: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9982511
CHEMBL ID	359501
MeSH ID	M0442646

Synonyms (12)

Synonym
4,4''''-dimethoxy-[1,1'''']biphenanthrenyl-2,7,2'''',7''''-tetraol
bdbm50160804
CHEMBL359501 ,
cirrhopetalanthin
blestriarene c
1-(2,7-dihydroxy-4-methoxyphenanthren-1-yl)-4-methoxyphenanthrene-2,7-diol
4,4'-dimethoxy[1,1'-biphenanthrene]-2,2',7,7'-tetrol
511256-45-4
DTXSID101219520
1-(2,7-dihydroxy-4-methoxy-1-phenanthryl)-4-methoxyphenanthrene-2,7-diol
AKOS040763200
120090-81-5

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Beta-tubulin	Leishmania donovani	IC50 (µMol)	30.0000	1.0000	1.3800	2.0000	AID247822
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay ID	Title	Year	Journal	Article
AID377270	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay	2006	Journal of natural products, Jun, Volume: 69, Issue:6	Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
AID1228006	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
AID377273	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay	2006	Journal of natural products, Jun, Volume: 69, Issue:6	Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
AID1228010	Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
AID1228008	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
AID377272	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	2006	Journal of natural products, Jun, Volume: 69, Issue:6	Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
AID377023	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	2006	Journal of natural products, Jun, Volume: 69, Issue:6	Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
AID247822	Inhibition of tubulin polymerization interacting at the colchicine binding site.	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata.
AID1327613	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction	2016	Journal of natural products, 08-26, Volume: 79, Issue:8	Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity.
AID1228011	Antimicrobial activity against Bacillus subtilis CGMCC 1.1470 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
AID377274	Cytotoxicity against human WISH cells after 96 hrs by MTT assay	2006	Journal of natural products, Jun, Volume: 69, Issue:6	Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
AID1228009	Antimicrobial activity against Staphylococcus epidermidis CMCC 26069 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
AID1228012	Antimicrobial activity against Escherichia coli ATCC 35218 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
AID1327612	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal	2016	Journal of natural products, 08-26, Volume: 79, Issue:8	Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity.
AID377271	Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay	2006	Journal of natural products, Jun, Volume: 69, Issue:6	Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
AID1228013	Antimicrobial activity against Proteus vulgaris CMCC 49027 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
AID377022	Cytotoxicity against human A549 cells after 96 hrs by MTT assay	2006	Journal of natural products, Jun, Volume: 69, Issue:6	Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.
AID1228007	Antimicrobial activity against ampicillin-resistant Staphylococcus aureus ATCC 29213 assessed as complete prevention of visible growth after incubation at 37 degC for 18 to 20 hrs	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.36 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.44 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.36)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
4-hydroxybenzaldehyde [no description available]	2.13	1	0	hydroxybenzaldehyde	EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor; mouse metabolite; plant metabolite
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.11	1	0	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
vinblastine [no description available]	2.02	1	0
topotecan Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.. topotecan : A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.	2.03	1	0	pyranoindolizinoquinoline	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor
bis(4-(glucopyranosyloxy)benzyl) 2-sec-butylmalate militarine: isolated from Rhizoma Bletillae; structure in first source	2.13	1	0
7-hydroxy-2-methoxy-1,4-phenanthrenedione 7-hydroxy-2-methoxy-1,4-phenanthrenedione: structure in first source; from Dendrobium densiflorum	2.13	1	0
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	2.72	3	0	stilbene
fosbretabulin [no description available]	2.02	1	0	stilbenoid
erianthridin erianthridin: isolated from an extract of the orchid Maxillaria densa; structure in first source	2.13	1	0
3,7-dihydroxy-2,4-dimethoxyphenanthrene 3,7-dihydroxy-2,4-dimethoxyphenanthrene: from the orchid Scaphyglottis livida; structure in first source	2.13	1	0
batatasin-iii [no description available]	2.13	1	0	stilbenoid
idelalisib idelalisib: an antineoplastic agent and p110delta inhibitor; structure in first source. idelalisib : A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.	2.13	1	0	aromatic amine; organofluorine compound; purines; quinazolines; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	2.72	3	0