dibenzacridine profile

Dibenzacridine is a polycyclic aromatic hydrocarbon with a distinctive molecular structure characterized by two fused acridine units. Its synthesis typically involves multi-step reactions starting with anthracene derivatives and subsequent ring closures. Research on dibenzacridine has primarily focused on its potential applications in various fields, including:
1. **Materials science:** Dibenzacridine derivatives have shown promising fluorescence properties and have been investigated as potential organic semiconductors.
2. **Drug discovery:** Some dibenzacridine derivatives exhibit biological activity, specifically as anti-cancer agents.
3. **Photochemistry:** Dibenzacridine's photophysical properties make it a subject of interest in photochemistry research.
4. **Organic electronics:** Dibenzacridine derivatives have been explored for their potential applications in organic light-emitting diodes (OLEDs).
5. **Theoretical chemistry:** Dibenzacridine's complex structure provides a challenging system for theoretical studies on electronic structure and molecular properties.
6. **Environmental chemistry:** Dibenzacridine and its derivatives have been found in various environmental samples, prompting research into their potential toxicity and environmental fate.
The study of dibenzacridine continues to be driven by its unique structural features, diverse potential applications, and potential environmental impact.'

dibenzacridine: RN given refers to dibenz(a,j)acridine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	9165
SCHEMBL ID	730399
MeSH ID	M0078088

Synonym
dibenzo[a,c]acridine
dibenz[a,c]acridine
215-62-3
nsc-48754
nsc48754
dibenzacridine
dibenz(a,c)acridine
ccris 1891
nsc 48754
phenanthro[9,10-b]quinoline
65777-07-3
FT-0631875
AKOS015905544
SCHEMBL730399
dibenzo(a,c)acridine
GUZBPGZOTDAWBO-UHFFFAOYSA-N
dibenzo[a,c]acridine #
dibenz[a,c]acridine, bcr(r) certified reference material
J-014146
1,2,3,4-dibenzacridin
DTXSID40878543
15-azapentacyclo[12.8.0.0?,?.0?,??.0??,??]docosa-1,3,5,7,9,11,13,15,17,19,21-undecaene
dibenz (a,c) acridine (purity)
1,2:3,4-dibenzacridine
KHE7JV8NGB

Excerpt	Relevance	Reference
" Dose-response relationships were obtained for DBa,hAC as well as for BaP."	( Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs. Brune, H; Deutsch-Wenzel, RP; Grimmer, G, 1983)	0.27
" Via intratracheal instillation, male CD rats (6/group) were dosed 3 times with BA, DBA, DBP or DBAC in a 24-h interval."	( Induction of in vivo DNA adducts by 4 industrial by-products in the rat-lung-cell system. Cutler, D; Ong, T; Stewart, JD; Whong, WZ, 1994)	0.29

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	15 (41.67)	18.7374
1990's	15 (41.67)	18.2507
2000's	4 (11.11)	29.6817
2010's	2 (5.56)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.13%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (94.87%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	1.98	1	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
3-methylcholanthrene Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.	3.36	7	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	3.68	10	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	2.66	3	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
safrole Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).. safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.	1.97	1	benzodioxoles	flavouring agent; insecticide; metabolite; plant metabolite
usnic acid [no description available]	3.16	1	benzofurans
1,2,5,6-dibenzanthracene 1,2,5,6-dibenzanthracene: RN given refers to parent cpd	2.42	2	ortho-fused polycyclic arene	mutagen
benz(a)anthracene benz(a)anthracene: 4 fused rings of which one is angular in contrast to the linear NAPHTHACENES. tetraphene : An angular ortho-fused polycyclic arene consisting of four fused benzene rings.	1.98	1	ortho-fused polycyclic arene; tetraphenes
9,10-dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.	1.97	1	ortho-fused polycyclic arene; tetraphenes	carcinogenic agent
benzo(f)quinoline [no description available]	1.96	1
dibenzo(a,i)pyrene [no description available]	2.42	2	ortho- and peri-fused polycyclic arene
dibenzo(a,h)pyrene dibenzo(a,h)pyrene: structure given in first source	2.06	1	ortho- and peri-fused polycyclic arene
indeno(1,2,3-cd)pyrene indeno(1,2,3-cd)pyrene: structure in first source	2.06	1	pyrenes
7h-dibenzo(c,g)carbazole [no description available]	4.34	6	carbazoles
benzo(j)fluoranthene benzo(j)fluoranthene: dihydrodiol metabolites identified as mutagens; structure given in first source	2.06	1	naphthalenes
benzo(b)fluoranthene benzo[b]fluoranthene : An ortho- and peri-fused polycyclic arene that consists of a benzene ring fused with a acephenanthrylene ring.	2.06	1	ortho- and peri-fused polycyclic arene	mutagen
benzo(k)fluoranthene [no description available]	2.06	1	naphthalenes
benz(a)acridine [no description available]	1.96	1	organonitrogen heterocyclic compound; polycyclic heteroarene
benz(c)acridine [no description available]	1.96	1	organonitrogen heterocyclic compound; polycyclic heteroarene
acridines Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.	6.5	36	acridines; mancude organic heterotricyclic parent; polycyclic heteroarene	genotoxin
6-chrysenamine 6-chrysenamine: may cause splenic atrophy and leukopenia; minor descriptor (76-84); on-line & Index Medicus search PHENANTHRENES (76-84)	1.97	1	carbopolycyclic compound
5-methylchrysene 5-methylchrysene: methylchrysenes in tobacco smoke are suspected to contribute to tumorigenicity of this inhalant; RN given refers to unlabeled cpd; structure	2.06	1	carbopolycyclic compound
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.39	2	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
stilbene oxide stilbene oxide: inducer of epoxide hydratase; RN given refers to cpd without isomeric designation	1.97	1	epoxide
glycoluril glycoluril: a compound made of two 2-imidazolidinone fused at the 4 and 5 positions	3.16	1	azabicycloalkane; ureas
7-methylbenz(c)acridine [no description available]	2.67	3
dibenz(a,h)anthracene-3,4-diol 1,2-oxide dibenz(a,h)anthracene-3,4-diol 1,2-oxide: structure given in first source; RN refers to (1a alpha,2 beta,3 alpha,13c alpha)-isomer	2.41	2
fullerene c60 Fullerenes: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.. fullerene : A compound composed solely of an even number of carbon atoms, which form a cage-like fused-ring polycyclic system with twelve five-membered rings and the rest six-membered rings. The term has been broadened to include any closed cage structure consisting entirely of three-coordinate carbon atoms.	3.16	1	fullerene	geroprotector
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	3.16	1
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	1.97	1	stilbene
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	2.39	2
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	1.97	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.06	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.06	1
Adenocarcinoma, Basal Cell [description not available]	1.96	1
Carcinoma, Epidermoid [description not available]	1.96	1
Cancer of Lung [description not available]	3.81	4
EHS Tumor [description not available]	1.96	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.96	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.96	1
Lung Neoplasms Tumors or cancer of the LUNG.	3.81	4
Stunted Growth [description not available]	1.96	1
Experimental Neoplasms [description not available]	2.65	3
Growth Disorders Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.	1.96	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.98	1
Experimental Hepatoma [description not available]	2.4	2
Cancer of Skin [description not available]	3.24	6
Skin Neoplasms Tumors or cancer of the SKIN.	3.24	6
Adenoma, Basal Cell [description not available]	2.9	1
Adenoma A benign epithelial tumor with a glandular organization.	2.9	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2	1
Papilloma, Squamous Cell [description not available]	2.39	2
Papilloma A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	2.39	2

dibenzacridine

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Studies (36)

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Research Demand Index: 22.22

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