Compounds > sandaracopimaric acid
Page last updated: 2024-12-08

sandaracopimaric acid

Description

sandaracopimaric acid: a terpenoid from Sagittaria sanittifolia L. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

sandaracopimaric acid : A pimarane diterpenoid that is (1S,4aS,4bS,7R,10aS)-1,4a,7-trimethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene carrying a carboxy group at position 1 and a vinyl group at position 7. It is a natural product found in several plant species. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
SagittariagenusA plant genus of the family ALISMATACEAE that grows in salty marshes and is used for phytoremediation of oil spills. The unisexual flowers have 3 sepals and 3 petals. Members contain trifoliones (DITERPENES).[MeSH]AlismataceaeA plant family of the subclass ALISMATIDAE, class Liliopsida (monocotyledons) of aquatic plants. The flower parts are in threes with 3 green sepals and 3 white or yellow petals.[MeSH]

Cross-References

ID SourceID
PubMed CID221580
CHEMBL ID513197
CHEBI ID69240
SCHEMBL ID4202964
MeSH IDM0218789

Synonyms (40)

Synonym
sandaracopimaric acid
isopimaric acid (d)
.delta.8(14)-isopimaric acid
nsc6435 ,
nsc-6435
1-phenanthrenecarboxylic acid,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, [1r-(1.alpha.,4a.beta.,4b.alpha.,7.alpha.,10a.alpha.)]-
isodextropimaric acid
cryptopimaric acid
471-74-9
podocarp-8(14)-en-15-oic acid, 13.beta.-methyl-13-vinyl-
(-)-sandaracopimaric acid
isopimaric acid (d-)
(2r,6r,12r)-2,6,12-trimethyl-12-vinyltricyclo[8.4.0.0<2,7>]tetradec-10-ene-6-carboxylic acid
sandracopimaric acid
(1r,4ar,4bs,7r,10ar)-1,4a,7-trimethyl-7-vinyl-3,4,4b,5,6,9,10,10a-octahydro-2h-phenanthrene-1-carboxylic acid
podocarp-8(14)-en-15-oic acid, 13beta-methyl-13-vinyl-
chebi:69240 ,
CHEMBL513197
(1r,4ar,4bs,7r,10ar)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,9,10,10a-octahydro-2h-phenanthrene-1-carboxylic acid
1-phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1r-(1alpha,4a beta,4b alpha,7alpha,10a alpha))-
delta8(14)-isopimaric acid
p4bjh0ia3z ,
ai3-24620
13beta-methyl-13-vinylpodocarp-8(14)-en-15-oic acid
nsc 6435
unii-p4bjh0ia3z
13alpha-pimara-8(14),15-dien-18-oic acid
13beta-methyl-13-vinyl-podocarp-8(14)-en-15-oic acid
7-epipimara-8(14),18-dienoic acid
sandarakopimaric acid
1-phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1r,4ar,4bs,7r,10ar)-
SCHEMBL4202964
sandarakopimarsaure
isodextropimarsaure
DTXSID80893311
sandaracopimaric acid,98%
Q23823948
HY-133594
CS-0128318
AKOS040758151

Research Excerpts

Effects

ExcerptReferenceRelevance
"Sandaracopimaric acid has good immunosuppression action."( [Chemical constituents of Sagittaria sagittifolia L].
Ding, WP; Jiang, RS; Lin, YW; Yuan, JL, 1993)		1.01
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
tricyclic diterpenoidAny diterpenoid with a tricyclic skeleton.
monocarboxylic acidAn oxoacid containing a single carboxy group.
pimarane diterpenoid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (49)

Assay IDTitleYearJournalArticle
AID688292Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688304Ratio of isopimaric acid Imax to compound Imax for gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID398027Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 10 mol ratio relative to TPA2002Journal of natural products, Dec, Volume: 65, Issue:12
Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID688290Allosteric modulation of gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688445Agonist activity at gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688438Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2 expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 30 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688288Allosteric modulation of gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis relative to control2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688280Ratio of isopimaric acid EC50 to compound EC50 for gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688301Ratio of isopimaric acid Imax to compound Imax for gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688284Allosteric modulation of gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis relative to control2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID398028Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio after 48 hours relative to TPA2002Journal of natural products, Dec, Volume: 65, Issue:12
Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID1491119Anticonvulsant activity in 7-days post fertilized zebra fish larvae assessed as reduction in pentylenetetrazol-induced locomotor activity by measuring total distance traveled by larvae at 0.25 to 2 uM pretreated for 3 hrs followed by pentylenetetrazol add2017Journal of natural products, 05-26, Volume: 80, Issue:5
HPLC-Based Activity Profiling for GABA
AID688294Ratio of isopimaric acid EC50 to compound EC50 for gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688282Allosteric modulation of gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis relative to control2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID750855Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID1491116Toxicity in 7-days post fertilized zebra fish larvae after 1.5 to 24 hrs by microscopic analysis2017Journal of natural products, 05-26, Volume: 80, Issue:5
HPLC-Based Activity Profiling for GABA
AID750853Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID688443Agonist activity at gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688287Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis relative to control2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688303Ratio of isopimaric acid Imax to compound Imax for gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID750852Cytotoxicity against human A549 cells after 48 hrs by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID688446Anxiolytic activity in C57Bl/6N mouse assessed as ambulation distance at 1 mg/kg, ip measured after 30 mins by open field test ( Rvb = 31.8 +/- 1.7 m)2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688448Anxiolytic activity in C57Bl/6N mouse assessed as ambulation distance at 30 mg/kg, ip measured after 30 mins by open field test ( Rvb = 31.8 +/- 1.7 m)2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688285Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis relative to control2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688444Agonist activity at gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688289Allosteric modulation of gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID398025Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 500 mol ratio relative to TPA2002Journal of natural products, Dec, Volume: 65, Issue:12
Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID688296Ratio of isopimaric acid EC50 to compound EC50 for gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688286Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis relative to control2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688440Agonist activity at gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 300 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688295Ratio of isopimaric acid EC50 to compound EC50 for gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688297Ratio of isopimaric acid EC50 to compound EC50 for gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688300Ratio of isopimaric acid Imax to compound Imax for gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688298Ratio of isopimaric acid EC50 to compound EC50 for gamma-aminobutyric acid receptor A alpha5beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID398024Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 1000 mol ratio relative to TPA2002Journal of natural products, Dec, Volume: 65, Issue:12
Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID688302Ratio of isopimaric acid Imax to compound Imax for gamma-aminobutyric acid receptor A alpha2beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688439Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2 expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 100 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID750854Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID688436Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 30 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688293Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688442Agonist activity at gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688283Allosteric modulation of gamma-aminobutyric acid receptor A alpha3beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis relative to control2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID398026Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 100 mol ratio relative to TPA2002Journal of natural products, Dec, Volume: 65, Issue:12
Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID750851Cytotoxicity against human SW480 cells after 48 hrs by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID688291Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta3gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688441Agonist activity at gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688447Anxiolytic activity in C57Bl/6N mouse assessed as ambulation distance at 3 mg/kg, ip measured after 30 mins by open field test ( Rvb = 31.8 +/- 1.7 m)2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688437Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 100 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
AID688299Ratio of isopimaric acid Imax to compound Imax for gamma-aminobutyric acid receptor A alpha1beta1gamma2S expressed in Xenopus oocytes assessed as potentiation of GABA-mediated chloride current at 0.1 to 500 uM by voltage clamp analysis2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (18.18)18.7374
1990's1 (4.55)18.2507
2000's6 (27.27)29.6817
2010's11 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.67 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index5.17 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		2.0610amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
clotiazepam
clotiazepam: was heading 1975-94 (see under AZEPINES 1978-90; was Y 6047 see under AZEPINES 1975-77); Y 6047 was see CLOTIAZEPAM 1978-94; use AZEPINES to search CLOTIAZEPAM 1975-94; thienodiazepine derivative with actions similar to those of benzodiazepines		2.0610organic molecular entity
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		2.15101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source		2.110chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
midazolam
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.. midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.		2.0610imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound		anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative
triazolam
Triazolam: A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.		2.0610triazolobenzodiazepinesedative
camphene
camphene : A monoterpene with a bicyclic skeleton that is bicyclo[2.2.1]heptane substituted by geminal methyl groups at position 2 and a methylidene group at position 3. It is a widespread natural product found in many essential oils.		2.1310carbobicyclic compound;
monoterpene		fragrance;
plant metabolite
estragole
estragole : A phenylpropanoid that is chavicol in which the hydroxy group is replaced by a methoxy group.		2.1310alkenylbenzene;
monomethoxybenzene;
phenylpropanoid		carcinogenic agent;
flavouring agent;
genotoxin;
insect attractant;
plant metabolite
abietic acid
abietic acid : An abietane diterpenoid that is abieta-7,13-diene substituted by a carboxy group at position 18.		2.520abietane diterpenoid;
monocarboxylic acid		plant metabolite
beta-phellandrene
[no description available]		2.1310phellandreneplant metabolite
beta-pinene
beta-pinene: alpha-pinene is also available. beta-pinene : An isomer of pinene with an exocyclic double bond. It is a component of essential oils from many plants.		2.1310pineneplant metabolite
ng-nitroarginine methyl ester
NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.		2.110alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
magnolol
[no description available]		2.1510biphenyls
vexibinol
vexibinol: flavanol from Sophora; structure in first source; RN given refers to (S-(R*,S*))-isomer. sophoraflavanone G : A tetrahydroxyflavanone having a structure of naringenin bearing an additional hydroxyl substituent at position 2' as well as a (2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at position 8'.		2.1510(2S)-flavan-4-one;
4'-hydroxyflavanones;
tetrahydroxyflavanone		antimalarial;
antimicrobial agent;
antioxidant;
plant metabolite
totarol
totarol: structure given in first source; isolated from the bark of Podocarpus nagi		2.0610diterpenoidmetabolite
sugiol
sugiol: diterpene with anti-inflammatory activity from Calocedrus formosana bark; structure in first source. sugiol : An abietane diterpenoid that is ferruginol in which the methylene group para to the phenolic hydroxy group has been substituted by an oxo group.		2.0410abietane diterpenoid;
carbotricyclic compound;
cyclic terpene ketone;
meroterpenoid;
phenols		antineoplastic agent;
antioxidant;
antiviral agent;
plant metabolite;
radical scavenger
dehydroabietic acid
dehydroabietic acid: major aquatic toxicant in effluent of pulp and paper mills. dehydroabietic acid : An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group.. dehydroabietate : A monocarboxylic acid anion that is the conjugate base of dehydroabietic acid, obtained by deprotonation of the carboxy group.		3.3160abietane diterpenoid;
carbotricyclic compound;
monocarboxylic acid		allergen;
metabolite
lambertianic acid
lambertianic acid: structure in first sourcd		2.0410
pinusolide
pinusolide: RN given for (1S-(1alpha,4aalpha,5a,8abeta))-isomer; structure in first source		2.0610diterpene lactonemetabolite
methyl abietate
methyl abietate: RN given refers to (1R-(1alpha,4abeta,4balpha,10aalpha))-isomer		2.1310
pimaric acid
pimaric acid: RN given refers to (D)-isomer; structure		2.6730diterpenoid
ferruginol
ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.		2.0810abietane diterpenoid;
carbotricyclic compound;
meroterpenoid;
phenols		antibacterial agent;
antineoplastic agent;
plant metabolite;
protective agent
isopimaric acid
isopimaric acid: isolated from the bark of Illicium jadifengpi		2.7830carbotricyclic compound;
diterpenoid;
monocarboxylic acid
gamma-sitosterol
clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.		2.44203beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite
communic acid
communic acid: structure in first source		2.9640
piperine
piperine : A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.		2.1510benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide		food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite
kaurenoic acid
kaurenoic acid: isolated from leaves of Montanoa tomentosa; structure given in first source. ent-kaur-16-en-19-oic acid : An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity.		2.1310
cytellin
cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982		2.4420
beta carotene
beta Carotene: A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).. provitamin A : A provitamin that can be converted into vitamin A by enzymes from animal tissues.		2.0110carotenoid beta-end derivative;
cyclic carotene		antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		2.0710chalcogen;
nonmetal atom		macronutrient
isocupressic acid
isocupressic acid: a labdane that induces premature LABOR		2.4820
valerenic acid
valerenic acid: a saturated oplopanone type indene from Valeriana officinalis. valerenic acid : A monocarboxylic acid that is 2-methylprop-2-enoic acid which is substituted at position 3 by a 3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl group. A bicyclic sesquiterpenoid constituent of the essential oil of the Valerian plant.		2.1510carbobicyclic compound;
monocarboxylic acid;
sesquiterpenoid		GABA modulator;
plant metabolite;
sedative;
volatile oil component
labdane
labdane: from Croton joufra; structure in first source		2.0410diterpene;
terpenoid fundamental parent
lyoniside
lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer		2.0410
gibberellins
[no description available]		2.1310
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.7630
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure
[description not available]		02.1510
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.1510
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