panepophenanthrin: from a mushroom strain, an inhibitor of the ubiquitin-activating enzyme; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10432257 |
| CHEMBL ID | 2046774 |
| MeSH ID | M0442898 |
| Synonym |
|---|
| panepophenanthrin |
| bdbm50387036 |
| CHEMBL2046774 , |
| panepophenanthrine |
| (1s,2s,3r,4s,6s,10s,13r,14s,16s,17r,18s)-3,13,17-trihydroxy-18-[(e)-3-hydroxy-3-methylbut-1-enyl]-11,11-dimethyl-5,12,15-trioxahexacyclo[8.7.1.02,8.04,6.013,18.014,16]octadec-8-en-7-one |
| (1as,1br,3as,5as,6as,7r,7as,7bs,7cs,8r,8as)-1a,1b,3,3a,5a,6a,7,7a,7b,7c,8,8a-dodecahydro-1b,7,8-trihydroxy-7c-((1e)-3-hydroxy-3-methyl-1-buten-1-yl)-3,3-dimethyl-5h-bisoxireno(2,3:6,7)phenanthro(1,10-bc)furan-5-one |
| 5h-bisoxireno(2,3:6,7)phenanthro(1,10-bc)furan-5-one, 1a,1b,3,3a,5a,6a,7,7a,7b,7c,8,8a-dodecahydro-1b,7,8-trihydroxy-7c-((1e)-3-hydroxy-3-methyl-1-buten-1-yl)-3,3-dimethyl-, (1as,1br,3as,5as,6as,7r,7as,7bs,7cs,8r,8as)- |
| 791vps8i0j , |
| (+)-panepophenanthrin |
| 409064-57-9 |
| panepophenanthrin [mi] |
| unii-791vps8i0j |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| DNA damage response | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens (human) |
| protein ubiquitination | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens (human) |
| ubiquitin-dependent protein catabolic process | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| RNA binding | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens (human) |
| ubiquitin activating enzyme activity | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens (human) |
| protein binding | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens (human) |
| ATP binding | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID670507 | Inhibition of ubiquitin-activating enzyme E1 | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14 | Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||