culmorin

Description

Culmorin is a mycotoxin produced by the fungus Fusarium culmorum. It has been shown to have a variety of biological effects, including cytotoxic, anti-inflammatory, and antimicrobial activities. Culmorin is of interest to researchers due to its potential as a therapeutic agent, as well as its potential to contaminate food and feed. Culmorin is a potent inhibitor of the enzyme DNA polymerase, which is essential for DNA replication. This activity has led to research into its potential as an anticancer agent. Culmorin also inhibits the production of inflammatory cytokines, which suggests that it may have therapeutic potential for inflammatory diseases. In addition, culmorin has been shown to have antimicrobial activity against a variety of bacteria and fungi. The synthesis of culmorin has been studied in detail, and several methods have been developed for its production. However, the biosynthesis of culmorin is complex, and further research is needed to fully understand its mechanisms. Culmorin is a relatively rare mycotoxin, but it has been detected in a variety of food and feed products, including wheat, barley, and rice. The presence of culmorin in food can be a concern for human health, as it may have toxic effects. Therefore, it is important to monitor the levels of culmorin in food and feed products.'

culmorin: tricyclic sesquiterpene metabolite of fungus Fusarium culmorium; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

culmorin : A sesquiterpenoid fungal metabolite isolated from Fusarium culmorum. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]