Assay ID | Title | Year | Journal | Article |
AID1251581 | Solubility of the compound in 1:1 mixture of phosphate buffer and EtOH | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1388909 | Allosteric regulation of recombinant HSC70 (unknown origin) ATPase activity assessed as increase in ADP production at 10 uM after 10 mins in presence of HCV wild type poly U/UC RNA by HPLC analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1176194 | Antiproliferative activity against human NAMALWA cells after 72 hrs by ATPlite assay | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2
| Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs. |
AID698589 | Downregulation of HSP90 protein expression in human A549 cells at 3.6 to 100 nM after 48 hrs by Western blot analysis | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID378021 | Inhibition of hypoxia-induced HIF1alpha protein accumulation in human AGS cells after 12 hrs by Western blot | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. |
AID698590 | Downregulation of beta-casein protein expression in human A549 cells at 3.6 to 100 nM after 48 hrs by Western blot analysis | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID1251602 | Cell cycle arrest in human Caki1 cells assessed as accumulation at S phase at 1000 pM after 24 hrs by flow cytometry (Rvb = 13.4%) | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID258659 | Cytotoxicity against HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1176191 | Antiproliferative activity against human A549 cells after 72 hrs by ATPlite assay | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2
| Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs. |
AID378016 | Inhibition of hypoxia-induced HIF1 activation in human AGS cells after 16 hrs by pGL3-HRE-luciferase reporter gene assay | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. |
AID698605 | Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID1251588 | Oral bioavailability in ICR mouse at 10 mg/kg | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1251584 | Volume of distribution at steady state in ICR mouse at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1388904 | Antiviral activity against HCV genotype 1b con1 infected in human Huh-luc/neo-ET cells assessed as inhibition of viral replication after 72 hrs | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID698604 | Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID258655 | Cytotoxicity against human colon carcinoma, HCT15 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID698602 | Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID610918 | Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay | 2011 | Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14
| Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. |
AID1251587 | Elimination half-life in ICR mouse plasma at 10 mg/kg, po | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1388914 | Induction of HSC70 chaperone activity in human Huh-luc/neo-ET cells assessed as reduction in HCV RNA NS3 protein expression at 3 nM after 24 hrs | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID258665 | Cytotoxicity against human breast carcinoma, MCF7 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID258666 | Cytotoxicity against murine cytotoxic T cells, CTLL2 | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID258663 | Cytotoxicity against human uterine sarcoma, MES-SA cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID698597 | Cytotoxicity against human PC9IR cells assessed as cell viability after 48 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID698598 | Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID648632 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents. |
AID1251601 | Cell cycle arrest in human Caki1 cells assessed as accumulation at G0/G1 phase at 1000 pM after 24 hrs by flow cytometry (Rvb = 56.9%) | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1176192 | Antiproliferative activity against human A375 cells after 72 hrs by ATPlite assay | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2
| Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs. |
AID1251628 | Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID378019 | Inhibition of hypoxia-induced HIF1 activation in human AGS cells at 100 nM after 16 hrs by pGL3-HRE-luciferase reporter gene assay | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. |
AID258649 | Cytotoxicity against human breast carcinoma, BT20 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1176193 | Antiproliferative activity against human HCT116 cells after 72 hrs by ATPlite assay | 2015 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 25, Issue:2
| Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs. |
AID378017 | Inhibition of hypoxia-induced HIF1beta protein accumulation in human AGS cells after 12 hrs by Western blot | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. |
AID1388916 | Induction of HSC70 chaperone activity in human Huh-luc/neo-ET cells co-transfected with FLAG-tagged CHIP assessed as reduction in HCV RNA NS3 protein expression at 3 nM after 24 hrs | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1251623 | Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID610917 | Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay | 2011 | Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14
| Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. |
AID1388912 | Induction of HSC70 (unknown origin) chaperone activity assessed as reactivation of guanidine-denatured luciferase by luciferase reporter gene assay | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1251592 | Cell cycle arrest in human Caki1 cells assessed as accumulation at sub-G1 phase at 1000 pM after 24 hrs by flow cytometry (Rvb = 0.8%) | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1388919 | Induction of HSC70 chaperone activity in human Huh-luc/neo-ET cells co-transfected with FLAG-tagged CHIP assessed as reduction in HCV RNA NS5A protein expression at 3 nM after 24 hrs | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1388918 | Induction of HSC70 chaperone activity in human Huh-luc/neo-ET cells assessed as reduction in HCV RNA NS5A protein expression at 3 nM after 24 hrs | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID698600 | Cytotoxicity against human CL1-5 cells assessed as cell viability after 48 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID698561 | Cytotoxicity against human HCT8 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID258660 | Cytotoxicity against human fibroblast, BUD8 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1388908 | Cytotoxicity against human HepG2(2.2.15) cells assessed as cell growth inhibition | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1388923 | Effect on HSC70 expression in human HepG2(2.2.15) cells at 3 nM measured up to 72 hrs by Western blot analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1251585 | AUC (0 to infinity) in ICR mouse at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID258651 | Cytotoxicity against human osteosarcoma, KHOS-NP cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1251629 | Cytotoxicity against human Caki1 cells assessed as growth inhibition after 72 hrs by SRB assay | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1251627 | Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1251624 | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1251589 | AUC (0 to infinity) in ICR mouse at 10 mg/kg, po | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1388905 | Cytotoxicity against human Huh-luc/neo-ET cells assessed as cell growth inhibition | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID258657 | Cytotoxicity against human ovarian teratocarcinoma, PA1 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1251583 | Elimination half-life in ICR mouse plasma at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1251625 | Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID258664 | Cytotoxicity against human uterine sarcoma, MES-SA-Dx5 cells derived from MES-SA | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID258662 | Cytotoxicity against human Burkitt lymphoma, DAUDI cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1388913 | Induction of HSC70 (unknown origin) chaperone activity assessed as reactivation of guanidine-denatured luciferase at 10 uM in presence of human recombinant CHIP by luciferase reporter gene assay | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID258654 | Cytotoxicity against human lung carcinoma, A549 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID378018 | Inhibition of hypoxia-induced VEGF expression in human AGS cells after 16 hrs by RT-PCR analysis | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. |
AID258653 | Cytotoxicity against human melanoma, A375 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID610916 | Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay | 2011 | Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14
| Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. |
AID1388907 | Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral DNA level after 6 days by Southern blot analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1251626 | Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID258648 | Cytotoxicity against human erythroleukemia TF1 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1388921 | Effect on FLAF-tagged CHIP expression in human Huh-luc/neo-ET cells at 3 nM after 24 hrs | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID258661 | Cytotoxicity against human Burkitt lymphoma, RAMOS cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID1251586 | Cmax in ICR mouse plasma at 10 mg/kg, po | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID1388906 | Therapeutic index, ratio of IC50 for human Huh-luc/neo-ET cells to EC50 for HCV genotype 1b con1 | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. |
AID1251673 | Solubility of the compound in phosphate buffer at pH 7.4 | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID698588 | Downregulation of cyclin D protein expression in human A549 cells at 3.6 to 100 nM after 48 hrs by Western blot analysis | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID1251603 | Cell cycle arrest in human Caki1 cells assessed as accumulation at G2/M phase at 1000 pM after 24 hrs by flow cytometry (Rvb = 28.9%) | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID610948 | Toxicity against HUVEC | 2011 | Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14
| Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. |
AID258652 | Cytotoxicity against human epidermoid carcinoma, A431 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID648628 | Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents. |
AID258656 | Cytotoxicity against human bladder carcinoma, HT1376 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID698595 | Cytotoxicity against human MRC5 cells assessed as cell viability after 48 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID258650 | Cytotoxicity against rat prostate carcinoma, MatLyLu cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
AID610919 | Anticancer activity against human HCT8 cells after 72 hrs by sulforhodamine B assay | 2011 | Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14
| Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. |
AID698599 | Cytotoxicity against human CL1-0 cells assessed as cell viability after 48 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID698596 | Cytotoxicity against human PC9 cells assessed as cell viability after 48 hrs by SRB assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. |
AID1251582 | Clearance in ICR mouse plasma at 1 mg/kg, iv | 2015 | Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
| Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. |
AID258658 | Cytotoxicity against human hepatoma, HEPG2 cells | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
| C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |