Page last updated: 2024-12-08
bruceine a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
bruceine A: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to (11 beta,12 alpha,15 beta)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 160006 |
| CHEMBL ID | 250451 |
| CHEBI ID | 189511 |
| SCHEMBL ID | 5928607 |
| MeSH ID | M0083779 |
Synonyms (19)
| Synonym |
|---|
| nsc310616 |
| brucein a |
| nsc-310616 |
| 25514-31-2 |
| picras-3-en-21-oic acid,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11.beta.,12.alpha.,15.beta.)- |
| isobruceine a |
| CHEMBL250451 |
| methyl (1r,2s,3r,6r,8r,13s,14r,15r,16s,17s)-10,15,16-trihydroxy-9,13-dimethyl-3-(3-methylbutanoyloxy)-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate |
| CHEBI:189511 |
| bruceine a |
| nsc 310616 |
| picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11beta,12alpha,15beta)- |
| SCHEMBL5928607 |
| HY-N0841 |
| AKOS030526754 |
| mfcd28167765 |
| MS-29680 |
| dihydrobrusatol |
| DTXSID901318520 |
Research Excerpts
Overview
Bruceine A is a natural quassinoid compound extracted from the fruit of the Traditional Chinese Medicine Brucea javanica (L.) Merr.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bruceine A is a natural quassinoid compound extracted from the fruit of the Traditional Chinese Medicine Brucea javanica (L.) Merr. " | ( Bruceine A protects against diabetic kidney disease via inhibiting galectin-1. Li, H; Li, Y; Lin, S; Qiu, Q; Ren, H; Shen, J; Wang, X; Wang, Z; Zhao, X; Zheng, L, 2022) | 3.61 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
| Class | Description |
|---|---|
| quassinoid | Members of the class of triterpenoid, mostly isolated as bitter principles of the Simaroubaceae family. They are chemically regarded as degraded triterpenes and can be categorized into groups with C18, C19, C20, C22 and C25 skeletons. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Bioassays (16)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID337705 | Antimalarial activity as reduced parasitaemia at day 4 against Plasmodium berghei N infected TSW mice (Mus musculus) at 9 mg/kg perorally dosed 3 hrs post infection then daily | |||
| AID1707241 | Antiproliferative activity against human HT-29 cells | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. |
| AID417078 | Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. |
| AID1707245 | Cytotoxicity against human MCF-7 cells incubated for 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. |
| AID1707242 | Antiproliferative activity against human HeLa cells | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. |
| AID1707246 | Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. |
| AID337704 | Antimalarial activity as reduced parasitaemia at day 4 against Plasmodium berghei N infected TSW mice (Mus musculus) perorally dosed 3 hrs post infection then daily | |||
| AID1707171 | Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by WST-1 assay | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. |
| AID311567 | Antibabesial activity against Babesia gibsoni | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10 | Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica. |
| AID417080 | Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. |
| AID417082 | Ratio ED50 for human MCF7 cells to ED50 for human MCF7 cells in presence of 43 uM (-)-hydnocarpin | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. |
| AID337702 | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected human erythrocytes assessed by [3H]hypoxanthine uptake | |||
| AID1918735 | Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral propagation preincubated for 1 hrs followed by viral infection and measured after 24 hrs by qRT-PCR analysis | 2022 | Journal of natural products, 12-23, Volume: 85, Issue:12 | Evaluating the |
| AID417081 | Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay in presence of 43 uM (-)-hydnocarpin | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. |
| AID417079 | Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. |
| AID1707191 | Antiproliferative activity against human HL-60 cells | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (16)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 7 (43.75) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 19.49
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.49) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (5.88%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 16 (94.12%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||