| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group. | 1.95 | 1 | 0 | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source | 2.05 | 1 | 0 | delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol | antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite |
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL). | 2.05 | 1 | 0 | taxane diterpenoid;
tetracyclic diterpenoid | antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent |
diminazene aceturate
[no description available] | 2.03 | 1 | 0 | | |
simalikalactone d
simalikalactone D: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to ((11beta)-isomer); structure in first source. simalikalactone D : A quassinoid isolated from Quassia amara and Quassia africana. It has been shown to exhibit antimalarial, cytotoxic and antiviral activities. | 1.95 | 1 | 0 | | |
triptonide
triptonide: extracted from Tripterygium wilfordii; structure given in first source. triptonide : A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. | 2.25 | 1 | 0 | butenolide;
cyclic ketone;
diterpene triepoxide;
organic heteroheptacyclic compound | anti-inflammatory agent;
antineoplastic agent;
immunosuppressive agent |
nagilactone c
nagilactone C: norditerpene lactone isolated from leaves of Podocarpus; structure | 2.25 | 1 | 0 | | |
chaparrinone
chaparrinone: quassinoid which inhibits protein sunthesis & DNA synthesis in cells; structure in first source | 2.36 | 2 | 0 | triterpenoid | |
brusatol
brusatol: quassinoid from B. javanica; structure | 2.72 | 2 | 0 | triterpenoid | |
canthin-6-one
canthin-6-one: from Zanthoxylum usambarense; structure in first source. canthin-6-one : An indole alkaloid that is 6H-indolo[3,2,1-de][1,5]naphthyridine substituted by an oxo group at position 6. | 2.41 | 1 | 0 | enone;
indole alkaloid;
organic heterotetracyclic compound | antimycobacterial drug;
metabolite |
triptolide
[no description available] | 2.25 | 1 | 0 | diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound | antispermatogenic agent;
plant metabolite |
parthenolide
[no description available] | 2.25 | 1 | 0 | germacranolide | |
obacunone
obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane | 2.25 | 1 | 0 | limonoid | |
bruceine d
bruceine D: from fructus of Brucea javanica (Chinese name Yadanzi). bruceine D : A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity. | 7.45 | 2 | 0 | | |
chlorolissoclimide
chlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson | 2.25 | 1 | 0 | | |
bruceine b
bruceine B: quassinoid which inhibits protein synthesis & DNA synthesis in cells; structure in first source | 2.7 | 3 | 0 | triterpenoid | |
jolkinolide a
jolkinolide A: isolated from Euphorbia fischeriana | 2.25 | 1 | 0 | diterpene lactone | metabolite |
jolkinolide b
jolkinolide B: isolated from Euphorbia fischeriana | 2.25 | 1 | 0 | diterpene lactone | metabolite |
limonin
[no description available] | 2.25 | 1 | 0 | epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound | inhibitor;
metabolite;
volatile oil component |
glaucarubinone
glaucarubinone: structure. glaucarubinone : A quassinoid with formula C25H34O10. It is a natural product isolated from several plant species and exhibits anti-cancer and anti-malarial properties. | 1.95 | 1 | 0 | | |
tripdiolide
tripdiolide: structure | 2.25 | 1 | 0 | oxacycle | |
glaucarubolone
glaucarubolone: a quassinoid which inhibits protein synthesis & DNA synthesis in cells; structure in first source | 2.36 | 2 | 0 | triterpenoid | |
thapsigargin
Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. | 2.25 | 1 | 0 | butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone | calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor |
chrysoeriol
chrysoeriol: isolated from leaves of Eurya japonica & E. emarginata. 4',5,7-trihydroxy-3'-methoxyflavone : The 3'-O-methyl derivative of luteolin. | 2.05 | 1 | 0 | monomethoxyflavone;
trihydroxyflavone | antineoplastic agent;
antioxidant;
metabolite |
bruceantin
[no description available] | 2.78 | 3 | 0 | triterpenoid | |
andrographolide
[no description available] | 2.72 | 2 | 0 | carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol | anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite |
shihulimonin a
shihulimonin A: isolated from Evodia rutaecarpa; structure in first source | 2.25 | 1 | 0 | limonoid | |
beta-carboline-1-propionic acid
[no description available] | 2.41 | 1 | 0 | harmala alkaloid | |
dichapetalin a
dichapetalin A: isolated from Dichapetalum; structure in first source | 2.25 | 1 | 0 | | |
hydnocarpin
hydnocarpin: structure given in first source; isolated from Hydnocarpus wightiana seeds | 2.05 | 1 | 0 | | |
ginkgolide b
[no description available] | 2.25 | 1 | 0 | | |
17-hydroxyjolkinolide b
17-hydroxyjolkinolide B: isolated from Euphorbia fischeriana | 2.25 | 1 | 0 | diterpene lactone | metabolite |
9-methoxycanthin-6-one
9-methoxycanthin-6-one: from roots of Eurycoma longifolia (Simaroubaceae). 9-methoxycanthin-6-one : An indole alkaloid that is the 9-methoxy derivative of canthin-6-one. Isolated from Eurycoma longifolia and Simaba multiflora, it exhibits cytotoxic activity towards human cancer cell lines. | 2.41 | 1 | 0 | aromatic ether;
indole alkaloid;
organic heterotetracyclic compound | antineoplastic agent;
antiplasmodial drug;
metabolite |
bn 52020
[no description available] | 2.25 | 1 | 0 | | |
9-hydroxycanthin-6-one
9-hydroxycanthin-6-one: from Eurycoma longifolia Jack (Simaroubaceae), induces penile erection and delays ejaculation. 9-hydroxycanthin-6-one : An indole alkaloid that is canthin-6-one substituted by a hydroxy group at position 9. Isolated from the roots of Eurycoma longifolia, it exhibits antineoplastic activity. | 2.41 | 1 | 0 | | |
dichlorolissoclimide
dichlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson | 2.25 | 1 | 0 | | |
14-o-phosphonooxymethyltriptolide
14-O-phosphonooxymethyltriptolide disodium salt: pro-drug of triptolide; has antineoplastic activity | 2.25 | 1 | 0 | | |
eurycomanone
[no description available] | 2.41 | 1 | 0 | cyclic ether;
delta-lactone;
enone;
organic heteropentacyclic compound;
pentol;
quassinoid;
secondary alcohol;
secondary alpha-hydroxy ketone;
tertiary alcohol | antimalarial;
antineoplastic agent;
metabolite |
glaucarubin
Glaucarubin: (1 beta,2 alpha,11 beta,12 alpha,15 beta(S))-11,20-Epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)picras-3-en-16-one. A quassinoid (Simaroubolide) from Simaruba glauca, a tropical shrub. It has been used as an antiamebic agent and is found to be cytotoxic. It may be of use in cancer chemotherapy. | 2.36 | 2 | 0 | | |
ailanthone
ailanthone: structure in first source | 7.31 | 1 | 0 | | |
s 8932
[no description available] | 2.41 | 1 | 0 | aromatic amine;
C-nucleoside;
carboxylic ester;
nitrile;
phosphoramidate ester;
pyrrolotriazine | anticoronaviral agent;
antiviral drug;
prodrug |
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof. | 2.36 | 2 | 0 | | |