Compounds > 7-deoxypancratistatin
Page last updated: 2024-12-08

7-deoxypancratistatin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-deoxypancratistatin: a phytogenic antineoplastic agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID443741
CHEMBL ID98481
CHEBI ID31142
SCHEMBL ID21162145
MeSH IDM0376604

Synonyms (7)

Synonym
CHEMBL98481 ,
chebi:31142 ,
C12255 ,
7-deoxypancratistatin
(1r,2s,3s,4s,4ar,11br)-1,2,3,4-tetrahydroxy-2,3,4,4a,5,11b-hexahydro-1h-[1,3]dioxolo[4,5-j]phenanthridin-6-one
Q27114174
SCHEMBL21162145
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenanthridinesAny dibenzopyridine based on the skeleton of phenanthridine and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID336612Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336622Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Punta toro virus Adames1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID154171Tested for growth inhibition activity against murine P388 lymphocytic leukemia2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID335983Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as average day of death at 10 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days p1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336623Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335981Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as average day of death at 40 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days p1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336632Toxicity in C57BL/6 mouse assessed as mortality at 10 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336616Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335982Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as average day of death at 20 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days p1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335986Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as survival rate at 20 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days post inf1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID143046Tested for growth inhibition activity against lung NCI-H460 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID336615Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Yellow fever virus Ashibi1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336619Antiviral activity against HIV1 by cells based assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336631Toxicity in C57BL/6 mouse assessed as mortality at 20 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336621Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335985Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as survival rate at 40 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days post inf1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336625Antiviral activity against Sandfly fever sicilian virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335987Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as survival rate at 10 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days post inf1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID94881Tested for growth inhibition activity against colon KM20L2 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID336617Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Dengue type 4 virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336620Antiviral activity against Vaccinia virus Lederle vaccine infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336630Toxicity in C57BL/6 mouse assessed as mortality at 40 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336618Antiviral activity against Venezuelan equine encephalitis virus Trinidad donkey infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335988Toxicity in C57BL/6 mouse assessed as body weight loss at 40 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336614Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336626Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Sandfly fever sicilian virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336629Toxicity in C57BL/6 mouse assessed as average day of death at 2 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336613Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Japanese encephalitis virus Nakayama1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336624Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Rift valley fever virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's6 (46.15)29.6817
2010's6 (46.15)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.77 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		2.1510aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
phenanthrene
phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'		2.0510ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes		environmental contaminant;
mouse metabolite
aziridine
[no description available]		2.0510azacycloalkane;
aziridines;
saturated organic heteromonocyclic parent		alkylating agent
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		7.0310metal allergen;
nickel group element atom;
platinum group metal atom
alkenes
[no description available]		2.0310
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species		9.0240phenanthridinesmetabolite
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.		2.420indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
lycoricidine
lycoricidine: antineoplastic from daffodil (Narcissus) bulbs; structure in first source		1.9810phenanthridines
trans-dihydronarciclasine
[no description available]		1.9810
pancratistatin
pancratistatin: an isocarbostyril from Amaryllidaceae		4.3760citraconoyl group
pseudolycorine
pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source		1.9810phenanthridines
7-deoxy-trans-dihydronarciclasine
7-deoxy-trans-dihydronarciclasine: structure in first source		1.9810
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		7.0610aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
tamoxifen
[no description available]		2.4820stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor		2.0710
7-deoxynarciclasine
7-deoxynarciclasine: structure in first source		3.1410
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Japanese B
[description not available]		01.9810
Encephalitis, Japanese
A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)		01.9810
Colorectal Cancer
[description not available]		07.0710
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.0710
Cancer of Lung
[description not available]		02.0710
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0710
Osteogenic Sarcoma
[description not available]		02.0610
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)		07.0610
Breast Cancer
[description not available]		02.0710
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0710
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		07.0710
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0110