bruceine D: from fructus of Brucea javanica (Chinese name Yadanzi) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
bruceine D : A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Brucea | genus | A plant genus of the family SIMAROUBACEAE. Members contain bruceosides and bruceanols (quassinoids). The astringent seeds have been used to treat dysentery in southeastern Asia.[MeSH] | Simaroubaceae | A plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Leaves are alternate and compound. Most have small flowers, bitter bark, and fleshy fruits that are sometimes winged. Members contain QUASSINS.[MeSH] |
| Brucea javanica | species | A plant species in the genus Brucea and the family SIMAROUBACEAE. It was formerly classified in the family ANACARDIACEAE. Its seeds have been used as traditional medicine and contain various QUASSINS including bruceines and brusatol.[MeSH] | Simaroubaceae | A plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Leaves are alternate and compound. Most have small flowers, bitter bark, and fleshy fruits that are sometimes winged. Members contain QUASSINS.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 122784 |
| CHEMBL ID | 477693 |
| MeSH ID | M0096218 |
| Synonym |
|---|
| 5h-3,11c-beta-(epoxymethano)phenanthro(10,1-bc)pyran-5,10(6a-beta-h)-dione, 1,2,3,3a,4,7,7a-alpha,11,11a,11b-alpha-decahydro-1-beta,2-alpha,3a-beta,4-beta,11-beta-pentahydroxy-3-alpha,8,11a-beta-trimethyl-, (-)- |
| picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1beta,11beta,12alpha,15beta)- |
| nsc 318801 |
| brucein d |
| bruceine d |
| 21499-66-1 |
| CHEMBL477693 |
| (1r,2r,3r,6r,8s,12s,13s,14r,15r,16s,17s)-2,3,12,15,16-pentahydroxy-9,13,17-trimethyl-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-4,11-dione |
Bruceine D is a natural quassinoid, which was successfully isolated from the residue of Brucea javanica (L.) seeds.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bruceine D is a natural quassinoid, which was successfully isolated in our research group from the residue of Brucea javanica (L.) seeds. " | ( Bruceine D may affect the phenylpropanoid biosynthesis by acting on ADTs thus inhibiting Bidens pilosa L. seed germination. Liu, SY; Qiu, ZX; Tang, WW; Tong, Y; Xu, L; Yi, SC; Zeng, DQ, 2022) | 3.61 |
| "Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant " | ( Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis. Chen, VP; Dou, YX; Gao, JS; Huang, YF; Lin, ZX; Su, ZR; Wang, TT; Xie, YL; Zeng, HF; Zhou, JT, 2018) | 2.18 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bruceine D (BD) has been shown to induce pancreatic cancer cell death via several different mechanisms." | ( Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo. Fan, J; Liu, X; Ren, D; Wang, J; Wu, M; Yang, G; Zhang, H, 2020) | 2.72 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD." | ( Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis. Chen, VP; Dou, YX; Gao, JS; Huang, YF; Lin, ZX; Su, ZR; Wang, TT; Xie, YL; Zeng, HF; Zhou, JT, 2018) | 0.74 |
| "These results demonstrated that BD-SNEDDS exhibited highly improved oral bioavailability and advanced anti-UC efficacy." | ( Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis. Chen, VP; Dou, YX; Gao, JS; Huang, YF; Lin, ZX; Su, ZR; Wang, TT; Xie, YL; Zeng, HF; Zhou, JT, 2018) | 0.74 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1081314 | In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days af | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID337702 | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected human erythrocytes assessed by [3H]hypoxanthine uptake | |||
| AID632370 | Cytotoxicity against human A549 cells by MTT assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Indole alkaloids and quassinoids from the stems of Brucea mollis. |
| AID632372 | Cytotoxicity against human A2780 cells by MTT assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Indole alkaloids and quassinoids from the stems of Brucea mollis. |
| AID663853 | Cytotoxicity against human BGC823 cells by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Bioactive quassinoids from the seeds of Brucea javanica. |
| AID337704 | Antimalarial activity as reduced parasitaemia at day 4 against Plasmodium berghei N infected TSW mice (Mus musculus) perorally dosed 3 hrs post infection then daily | |||
| AID663855 | Cytotoxicity against human SKOV3 cells by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Bioactive quassinoids from the seeds of Brucea javanica. |
| AID1081315 | In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 10 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3- | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID1081318 | In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 1.25 uM co-incubated with virus for 30 min before inoculation onto leaves measured at | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID1081312 | Antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as decrease in Tobacco mosaic virus coat protein level at 20 uM at 25 degC treated at 6 hr after viral inoculation measured after 48 hr by | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID337708 | Toxicity in Plasmodium berghei N-infected TSW mice (Mus musculus) assessed as toxic deaths before day 5 at 3 mg/kg, perorally administered 3 hrs after infection daily for 4 consecutive days | |||
| AID1081319 | In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 20 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3- | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID1081310 | Antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected Nicotiana glutinosa leaves assessed as protective effect by decrease in local lesion number at 20 uM treated 6 hr prior to viral inoculation measured at 3-4 days after viral challeng | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID1081316 | In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 5 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID664574 | Cytotoxicity against human HCT8 cells by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Bioactive quassinoids from the seeds of Brucea javanica. |
| AID632368 | Cytotoxicity against human HCT8 cells by MTT assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Indole alkaloids and quassinoids from the stems of Brucea mollis. |
| AID632371 | Cytotoxicity against human BCG823 cells by MTT assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Indole alkaloids and quassinoids from the stems of Brucea mollis. |
| AID663854 | Cytotoxicity against human A549 cells by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Bioactive quassinoids from the seeds of Brucea javanica. |
| AID1081317 | In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 2.5 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3 | 2010 | Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3 | Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| AID311567 | Antibabesial activity against Babesia gibsoni | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10 | Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica. |
| AID663852 | Cytotoxicity against human HepG2 cells by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Bioactive quassinoids from the seeds of Brucea javanica. |
| AID337706 | Antimalarial activity as reduced parasitaemia at day 4 against Plasmodium berghei N infected TSW mice (Mus musculus) at 3 mg/kg peroral dose 3 hrs post infection then daily | |||
| AID632369 | Cytotoxicity against human Bel7402 cells by MTT assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Indole alkaloids and quassinoids from the stems of Brucea mollis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 16 (53.33) | 24.3611 |
| 2020's | 8 (26.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.56) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (3.23%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 30 (96.77%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||