Compounds > tylophorine b
Page last updated: 2024-11-11

tylophorine b

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Description

tylophorine B: isolated from Albizzia julibrissin; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5316514
CHEMBL ID244969
SCHEMBL ID13222735
MeSH IDM0363477

Synonyms (5)

Synonym
CHEMBL244969
(+/-)-antofine
2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizine
SCHEMBL13222735
tylophorine b
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID741429Cytotoxicity against human SKHEP1 cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
AID741210Cytotoxicity against human paclitaxel-resistant A549 cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
AID1081058Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 100 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID1081056Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 25 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID292718Cytotoxicity against human HT1080 cells by SRB assay2007Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
Synthesis and structure-activity studies of antofine analogues as potential anticancer agents.
AID1081059Antiviral activity against Tobacco mosaic virus (TMV) inoculated on 100 ug/mL compound smeared Nicotiana tabacum leaves assessed as protective effect against viral infection measured 3 to 4 days post viral infection2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID408664Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
AID1081053Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution for 20 min and measured 72 hr post compound treatment by half-leaf method2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID292717Cytotoxicity against human HCT116 cells by SRB assay2007Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
Synthesis and structure-activity studies of antofine analogues as potential anticancer agents.
AID408666Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
AID1081055Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 5 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID1081057Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 50 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID408667Cytotoxicity against human KB-VIN cells after 72 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
AID741238Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
AID1081051Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 100 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID292719Cytotoxicity against human A549 cells by SRB assay2007Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
Synthesis and structure-activity studies of antofine analogues as potential anticancer agents.
AID741431Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
AID408665Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.
AID1081049Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 100 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral inf2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
AID741237Cytotoxicity against human A549 cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
AID741430Cytotoxicity against human SNU638 cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.82 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.90 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		710aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
tylophorine
tylophorine: phenanthroindolizidine alkaloid		7.4320organic heteropentacyclic compound;
organonitrogen heterocyclic compound
antofine
antofine: structure in first source. (-)-antofine : An organic heteropentacyclic compound that is (13aR)-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups. It is an alkaloid produced by relatives of the milkweed family and exhibits antiviral, anti-inflammatory, antiadipogenic and antitumorigenic activities.		2.4620alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound		angiogenesis inhibitor;
anti-inflammatory agent;
antimicrobial agent;
antineoplastic agent;
antiviral agent;
phytotoxin;
plant metabolite
ningnanmycin
ningnanmycin: isolated from Strepcomces noursei		2.0510
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.7130
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung
[description not available]		02.0810
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0810