Page last updated: 2024-12-07

maleopimaric acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Maleopimaric acid is a diterpenoid resin acid that is found in pine resin. It is a potent inhibitor of the enzyme 5-lipoxygenase, which is involved in the production of leukotrienes, inflammatory mediators that contribute to asthma and other inflammatory diseases. Maleopimaric acid has been shown to have anti-inflammatory, analgesic, and anti-tumor activities in various studies. It is also a promising lead compound for the development of new drugs for the treatment of inflammatory diseases. The synthesis of maleopimaric acid has been studied, and various methods have been developed to produce this compound. Some researchers are interested in studying its effects on different biological systems and its potential applications in medicine and other fields.'

maleopimaric acid: RN given refers to (4 alpha,8 alpha,12 alpha,13R,14R)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92120
MeSH IDM0090095

Synonyms (16)

Synonym
maleopimaric acid
einecs 208-113-9
17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, 16-(1-methylethyl)-, cyclic 13,14-anhydride, (4alpha,8alpha,12alpha,13r,14r)-
2hq08s46wf ,
ai3-19189
510-39-4
unii-2hq08s46wf
(4alpha,8alpha,12alpha,13r,14r)-16-isopropyl-17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, cyclic 13,14-anhydride
(4.alpha.,8.alpha.,12.alpha.,13r,14r)-16-isopropyl-17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, cyclic 13,14-anhydride
maleoabietic anhydride
maleopimaric anhydride
atis-13-ene-17,18-dioic acid, 15.alpha.-carboxy-13-isopropyl-, cyclic 15,17-anhydride
(1s,4r,5r,9r,10r,12r,13r,17r)-5,9-dimethyl-14,16-dioxo-19-propan-2-yl-15-oxapentacyclo[10.5.2.01,10.04,9.013,17]nonadec-18-ene-5-carboxylic acid
DTXSID101316520
1ST160461
maleopimaricanhydride

Research Excerpts

Overview

Endo-maleopimaric acid (MPA) is a contact allergen formed when colophonium is "modified" with maleic anhydride or fumaric acid.

ExcerptReferenceRelevance
"Endo-maleopimaric acid (MPA) is a contact allergen formed when colophonium is "modified" with maleic anhydride or fumaric acid. "( Different physical forms of maleopimaric acid give different allergic responses.
Gäfvert, E; Karlberg, AT; Nilsson, AM; Nilsson, JL, 2002
)
1.12
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.00)18.7374
1990's6 (30.00)18.2507
2000's5 (25.00)29.6817
2010's6 (30.00)24.3611
2020's2 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.66 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index5.17 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (9.52%)6.00%
Case Studies1 (4.76%)4.05%
Observational0 (0.00%)0.25%
Other18 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]