maleopimaric acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Maleopimaric acid is a diterpenoid resin acid that is found in pine resin. It is a potent inhibitor of the enzyme 5-lipoxygenase, which is involved in the production of leukotrienes, inflammatory mediators that contribute to asthma and other inflammatory diseases. Maleopimaric acid has been shown to have anti-inflammatory, analgesic, and anti-tumor activities in various studies. It is also a promising lead compound for the development of new drugs for the treatment of inflammatory diseases. The synthesis of maleopimaric acid has been studied, and various methods have been developed to produce this compound. Some researchers are interested in studying its effects on different biological systems and its potential applications in medicine and other fields.'

maleopimaric acid: RN given refers to (4 alpha,8 alpha,12 alpha,13R,14R)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	92120
MeSH ID	M0090095

Synonyms (16)

Synonym
maleopimaric acid
einecs 208-113-9
17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, 16-(1-methylethyl)-, cyclic 13,14-anhydride, (4alpha,8alpha,12alpha,13r,14r)-
2hq08s46wf ,
ai3-19189
510-39-4
unii-2hq08s46wf
(4alpha,8alpha,12alpha,13r,14r)-16-isopropyl-17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, cyclic 13,14-anhydride
(4.alpha.,8.alpha.,12.alpha.,13r,14r)-16-isopropyl-17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, cyclic 13,14-anhydride
maleoabietic anhydride
maleopimaric anhydride
atis-13-ene-17,18-dioic acid, 15.alpha.-carboxy-13-isopropyl-, cyclic 15,17-anhydride
(1s,4r,5r,9r,10r,12r,13r,17r)-5,9-dimethyl-14,16-dioxo-19-propan-2-yl-15-oxapentacyclo[10.5.2.01,10.04,9.013,17]nonadec-18-ene-5-carboxylic acid
DTXSID101316520
1ST160461
maleopimaricanhydride

Research Excerpts

Overview

Endo-maleopimaric acid (MPA) is a contact allergen formed when colophonium is "modified" with maleic anhydride or fumaric acid.

Excerpt	Reference	Relevance
"Endo-maleopimaric acid (MPA) is a contact allergen formed when colophonium is "modified" with maleic anhydride or fumaric acid. "	( Different physical forms of maleopimaric acid give different allergic responses. Gäfvert, E; Karlberg, AT; Nilsson, AM; Nilsson, JL, 2002)	1.12

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (5.00)	18.7374
1990's	6 (30.00)	18.2507
2000's	5 (25.00)	29.6817
2010's	6 (30.00)	24.3611
2020's	2 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	22.66 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	5.17 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (22.66)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (9.52%)	6.00%
Case Studies	1 (4.76%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2.39	2	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	1.99	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.05	1	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
glycidyl methacrylate glycidyl methacrylate: RN given refers to monomer. glycidyl methacrylate : An enoate ester obtained by formal condensation of the carboxy group of methacrylic acid with the hydroxy group of glycidol.	7.6	1	enoate ester; epoxide
maleic anhydride Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.	2.03	1	cyclic dicarboxylic anhydride; furans	allergen
thiazoles [no description available]	2.31	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
abietic acid abietic acid : An abietane diterpenoid that is abieta-7,13-diene substituted by a carboxy group at position 18.	1.98	1	abietane diterpenoid; monocarboxylic acid	plant metabolite
15-hydroperoxyabietic acid 15-hydroperoxyabietic acid: isolated from Portuguese colophony of gum rosin; structure given in first source	2.39	2
pimaric acid pimaric acid: RN given refers to (D)-isomer; structure	2.1	1	diterpenoid
fumaric acid fumaric acid: see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters. fumaric acid : A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.	2.03	1	butenedioic acid	food acidity regulator; fundamental metabolite; geroprotector
rosin rosin: Resin from plant. Do not confuse with the specific compound: 3-phenyl-2-propenyl-(E)-beta-D-glucopyranoside, also know as rosin.	8.5	8
fumarates Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)	2.03	1	butenedioate; C4-dicarboxylate	human metabolite; metabolite; Saccharomyces cerevisiae metabolite
trypan blue Trypan Blue: A diazo-naphthalene sulfonate that is widely used as a stain.. trypan blue : An organosulfonate salt that is the tetrasodium salt of 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonic acid).	3.05	1
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	1.98	1

Condition	Relationship Strength	Studies
Angioneurotic Edema [description not available]	2.87	1
Extravascular Hemolysis [description not available]	2.87	1
Angioedema Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.	2.87	1
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2.87	1
Allergic Contact Dermatitis [description not available]	2.91	4
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.91	4
Dermatitis, Occupational A recurrent contact dermatitis caused by substances found in the work place.	1.99	1
Contact Dermatitis [description not available]	2.38	2
Diseases, Occupational [description not available]	1.98	1
Hand Dermatosis [description not available]	1.98	1
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	2.38	2
Hand Dermatoses Skin diseases involving the HANDS.	1.98	1

chemdatabank.com