Maleopimaric acid is a diterpenoid resin acid that is found in pine resin. It is a potent inhibitor of the enzyme 5-lipoxygenase, which is involved in the production of leukotrienes, inflammatory mediators that contribute to asthma and other inflammatory diseases. Maleopimaric acid has been shown to have anti-inflammatory, analgesic, and anti-tumor activities in various studies. It is also a promising lead compound for the development of new drugs for the treatment of inflammatory diseases. The synthesis of maleopimaric acid has been studied, and various methods have been developed to produce this compound. Some researchers are interested in studying its effects on different biological systems and its potential applications in medicine and other fields.'
maleopimaric acid: RN given refers to (4 alpha,8 alpha,12 alpha,13R,14R)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 92120 |
MeSH ID | M0090095 |
Synonym |
---|
maleopimaric acid |
einecs 208-113-9 |
17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, 16-(1-methylethyl)-, cyclic 13,14-anhydride, (4alpha,8alpha,12alpha,13r,14r)- |
2hq08s46wf , |
ai3-19189 |
510-39-4 |
unii-2hq08s46wf |
(4alpha,8alpha,12alpha,13r,14r)-16-isopropyl-17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, cyclic 13,14-anhydride |
(4.alpha.,8.alpha.,12.alpha.,13r,14r)-16-isopropyl-17,19-dinoratis-15-ene-4,13,14-tricarboxylic acid, cyclic 13,14-anhydride |
maleoabietic anhydride |
maleopimaric anhydride |
atis-13-ene-17,18-dioic acid, 15.alpha.-carboxy-13-isopropyl-, cyclic 15,17-anhydride |
(1s,4r,5r,9r,10r,12r,13r,17r)-5,9-dimethyl-14,16-dioxo-19-propan-2-yl-15-oxapentacyclo[10.5.2.01,10.04,9.013,17]nonadec-18-ene-5-carboxylic acid |
DTXSID101316520 |
1ST160461 |
maleopimaricanhydride |
Endo-maleopimaric acid (MPA) is a contact allergen formed when colophonium is "modified" with maleic anhydride or fumaric acid.
Excerpt | Reference | Relevance |
---|---|---|
"Endo-maleopimaric acid (MPA) is a contact allergen formed when colophonium is "modified" with maleic anhydride or fumaric acid. " | ( Different physical forms of maleopimaric acid give different allergic responses. Gäfvert, E; Karlberg, AT; Nilsson, AM; Nilsson, JL, 2002) | 1.12 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (5.00) | 18.7374 |
1990's | 6 (30.00) | 18.2507 |
2000's | 5 (25.00) | 29.6817 |
2010's | 6 (30.00) | 24.3611 |
2020's | 2 (10.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (22.66) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 2 (9.52%) | 6.00% |
Case Studies | 1 (4.76%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 18 (85.71%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |