Page last updated: 2024-12-10

wilforine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

wilforine: isolated from Tripterygium wilfordii; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

wilforine : An organic heteropentacyclic compound and pyridine alkaloid with formula C43H49NO18 originally isolated from the roots of Tripterygium wilfordii. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
TripterygiumgenusA plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.[MeSH]CelastraceaeA plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID146156443
MeSH IDM0529530

Synonyms (2)

Synonym
wilforine
11088-09-8

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Further acute oral toxicity experiments showed that the LD50 value of this extract was 1,210 mg/kg compared to 257 mg/kg for Tripterygium glycosides."( Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
Fang, W; Lam, CW; Peng, F; Wan, C; Xu, H; Yang, X; Yi, T; Zhang, C, 2012
)
0.38

Bioavailability

ExcerptReferenceRelevance
"02-100 ng/mL, and successfully applied to a bioavailability study of wilforine in rats after intravenous and oral administration."( Application of a sensitive and specific LC-MS/MS method for determination of wilforine from Tripterygium wilfordii Hook. F. in rat plasma for a bioavailability study.
Di, B; Hang, TJ; Song, M; Su, MX, 2015
)
0.42

Dosage Studied

ExcerptRelevanceReference
" Then, a PK-PD research was carried out in adjuvant arthritis (AA) rats and control rats after oral administration of TGT, with different dosage and timing."( Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study.
An, L; Du, X; Gao, X; He, X; Huang, C; Wang, L; Wang, Y; Wu, Z, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's9 (64.29)24.3611
2020's4 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]