| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. | 2.02 | 1 | 0 | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mouse metabolite |
pd 98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'. | 2.02 | 1 | 0 | aromatic amine;
monomethoxyflavone | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector |
sb 202190
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase | 2.02 | 1 | 0 | imidazoles;
organofluorine compound;
phenols;
pyridines | apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
chrysene
chrysene: structure in Merck Index, 9th ed, #2252. chrysene : An ortho-fused polycyclic arene found commonly in the coal tar. | 2.66 | 3 | 0 | ortho-fused polycyclic arene | plant metabolite |
5-methylchrysene
5-methylchrysene: methylchrysenes in tobacco smoke are suspected to contribute to tumorigenicity of this inhalant; RN given refers to unlabeled cpd; structure | 1.97 | 1 | 0 | carbopolycyclic compound | |
5,6-dimethylchrysene
5,6-dimethylchrysene: structure given in first source | 1.97 | 1 | 0 | | |
4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene
4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene: RN given refers to cpd without isomeric designation | 1.99 | 1 | 0 | | |
chlorodiphenyl (54% chlorine)
Chlorodiphenyl (54% Chlorine): A mixture of polychlorinated biphenyls that induces hepatic microsomal UDP-glucuronyl transferase activity towards thyroxine.. Aroclor 1254 : A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H). | 1.98 | 1 | 0 | | |
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity. | 2.68 | 3 | 0 | epoxide | intercalator |
7,8,9,10-tetrahydroxytetrahydrobenzo(a)pyrene
7,8,9,10-tetrahydroxytetrahydrobenzo(a)pyrene: RN given refers to cpd without isomeric designation | 1.99 | 1 | 0 | | |
1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene
1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene: 5-methyl group increases its carcinogenic activity | 2.02 | 1 | 0 | | |
1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene
1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene: RN given refers to compound with no isomeric designation; do not confuse with the tetrahydrobenz(a)anthracene analog | 1.98 | 1 | 0 | | |
dibenz(a,h)anthracene-3,4-diol 1,2-oxide
dibenz(a,h)anthracene-3,4-diol 1,2-oxide: structure given in first source; RN refers to (1a alpha,2 beta,3 alpha,13c alpha)-isomer | 1.98 | 1 | 0 | | |
3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene
3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene: intermediate in carcinogenic & mutagenic process; RN given refers to cpd without isomeric designation; structure in first source | 1.96 | 1 | 0 | | |
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof. | 4.86 | 11 | 0 | | |