chrysene,2-diol-3,4-epoxide-1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

chrysene,2-diol-3,4-epoxide-1: denotes tumorigenic activity; RN given refers to cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	114730
CHEMBL ID	1743214
MeSH ID	M0077541

Synonyms (9)

Synonym
CHEMBL1743214
anti-cde
1,2,2a,3a-tetrahydrochryseno(3,4-b)oxirene-1,2-diol
chryseno(3,4-b)oxirene-1,2-diol, 1,2,2a,3a-tetrahydro-
chrysene,2-diol-3,4-epoxide-1
(+-)-1beta,2alpha-dihydroxy-3beta,4beta-epoxy-1,2,3,4-tetrahydrochrysene
67252-82-8
1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene
4-oxapentacyclo[9.8.0.02,8.03,5.012,17]nonadeca-1(11),2(8),9,12,14,16,18-heptaene-6,7-diol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	9 (60.00)	18.7374
1990's	4 (26.67)	18.2507
2000's	1 (6.67)	29.6817
2010's	1 (6.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.37 (24.57)
Research Supply Index	2.89 (2.92)
Research Growth Index	4.26 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.37)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.88%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (94.12%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	2.02	1	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
pd 98059 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.	2.02	1	aromatic amine; monomethoxyflavone	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector
sb 202190 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase	2.02	1	imidazoles; organofluorine compound; phenols; pyridines	apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
chrysene chrysene: structure in Merck Index, 9th ed, #2252. chrysene : An ortho-fused polycyclic arene found commonly in the coal tar.	2.66	3	ortho-fused polycyclic arene	plant metabolite
5-methylchrysene 5-methylchrysene: methylchrysenes in tobacco smoke are suspected to contribute to tumorigenicity of this inhalant; RN given refers to unlabeled cpd; structure	1.97	1	carbopolycyclic compound
5,6-dimethylchrysene 5,6-dimethylchrysene: structure given in first source	1.97	1
4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene 4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene: RN given refers to cpd without isomeric designation	1.99	1
chlorodiphenyl (54% chlorine) Chlorodiphenyl (54% Chlorine): A mixture of polychlorinated biphenyls that induces hepatic microsomal UDP-glucuronyl transferase activity towards thyroxine.. Aroclor 1254 : A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).	1.98	1
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.	2.68	3	epoxide	intercalator
7,8,9,10-tetrahydroxytetrahydrobenzo(a)pyrene 7,8,9,10-tetrahydroxytetrahydrobenzo(a)pyrene: RN given refers to cpd without isomeric designation	1.99	1
1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene 1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene: 5-methyl group increases its carcinogenic activity	2.02	1
1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene 1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene: RN given refers to compound with no isomeric designation; do not confuse with the tetrahydrobenz(a)anthracene analog	1.98	1
dibenz(a,h)anthracene-3,4-diol 1,2-oxide dibenz(a,h)anthracene-3,4-diol 1,2-oxide: structure given in first source; RN refers to (1a alpha,2 beta,3 alpha,13c alpha)-isomer	1.98	1
3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene 3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene: intermediate in carcinogenic & mutagenic process; RN given refers to cpd without isomeric designation; structure in first source	1.96	1
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	4.86	11

Condition	Relationship Strength	Studies
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.08	1
Cancer of Skin [description not available]	2.68	3
Skin Neoplasms Tumors or cancer of the SKIN.	2.68	3
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.96	1

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