Compounds > erianthridin
Page last updated: 2024-11-12

erianthridin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

erianthridin: isolated from an extract of the orchid Maxillaria densa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Maxillariagenus[no description available]OrchidaceaeA plant family of the order Asparagales. All members of the orchid family have the same bilaterally symmetrical flower structure, with three sepals, but the flowers vary greatly in color and shape.[MeSH]

Cross-References

ID SourceID
PubMed CID10401022
CHEMBL ID253982
MeSH IDM0443113

Synonyms (5)

Synonym
3,4-dimethoxy-9,10-dihydrophenanthrene-2,7-diol
CHEMBL253982
erianthridin
101508-48-9
DTXSID601318052
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID718301Vasorelaxant activity in Wistar rat aorta without endothelium assessed as inhibition of norepinephrine-induced contraction relative to control2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Ex vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa.
AID1320960Antifungal activity against Pestallozzia theae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320952Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1327612Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal2016Journal of natural products, 08-26, Volume: 79, Issue:8
Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity.
AID312044Cytotoxicity against rat hepatocytes at 10 to 100 uM2007Journal of natural products, Dec, Volume: 70, Issue:12
Antifibrotic phenanthrenes of Dendrobium nobile stems.
AID1320958Antifungal activity against Ceratocystis paradoxa moreau after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320961Antifungal activity against Alternaria citri after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID718302Vasorelaxant activity in Wistar rat aorta without endothelium assessed as inhibition of norepinephrine-induced contraction2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Ex vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa.
AID1540255Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay2019Journal of natural products, 08-23, Volume: 82, Issue:8
Isolation, Structural Elucidation, Optical Resolution, and Antineuroinflammatory Activity of Phenanthrene and 9,10-Dihydrophenanthrene Derivatives from
AID1320953Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID312043Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Antifibrotic phenanthrenes of Dendrobium nobile stems.
AID1320954Antifungal activity against Phytophthora parasitica var. nicotianae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID718304Vasorelaxant activity in Wistar rat aorta with endothelium assessed as inhibition of norepinephrine-induced contraction2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Ex vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa.
AID1327613Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction2016Journal of natural products, 08-26, Volume: 79, Issue:8
Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity.
AID718303Vasorelaxant activity in Wistar rat aorta with endothelium assessed as inhibition of norepinephrine-induced contraction relative to control2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Ex vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa.
AID484514Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells.
AID668096Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Phenanthrene derivatives from Cymbidium Great Flower Marie Laurencin and their biological activities.
AID1320959Antifungal activity against Exserohilum turcicum after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320955Antifungal activity against Colletotrichum capsici after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320951Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320950Antifungal activity against Alternaria brassicicola after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320956Antifungal activity against Bipolaris oryzae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320957Antifungal activity against Diaporthe medusaea nitschke after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's7 (63.64)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.52 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.01 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzaldehyde
[no description available]		2.1310hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0510guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
nifedipine
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.		2.0710C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.0710mitomycinalkylating agent;
antineoplastic agent
carbachol
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.		2.0710ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0710beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
diphenyl
diphenyl: RN given refers to unlabeled cpd; structure		2.1510aromatic fungicide;
benzenes;
biphenyls		antifungal agrochemical;
antimicrobial food preservative
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.0310flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
prochloraz
Mirage: a feldspathic porcelain that can be etched & bonded to the tooth. prochloraz : A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.		2.1310amide fungicide;
aromatic ether;
conazole fungicide;
imidazole fungicide;
imidazoles;
trichlorobenzene;
ureas		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
bis(4-(glucopyranosyloxy)benzyl) 2-sec-butylmalate
militarine: isolated from Rhizoma Bletillae; structure in first source		2.1310
dendrophenol
dendrophenol: isolated from Dendrobium loddigesii		2.0510
lusianthridin
lusianthridin: from rhizome of Arundina graminifolia		2.9940dihydrophenanthrene
Hircinol
[no description available]		2.4920phenanthrenes
7-hydroxy-2-methoxy-1,4-phenanthrenedione
7-hydroxy-2-methoxy-1,4-phenanthrenedione: structure in first source; from Dendrobium densiflorum		2.1310
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.1510stilbene
blestriarene c
blestriarene C: structure in first source		2.1310
denbinobin
denbinobin: antineoplastic from Dendrobium moniliforme (Orchidaceae); structure in first source		2.0310
3,7-dihydroxy-2,4-dimethoxyphenanthrene
3,7-dihydroxy-2,4-dimethoxyphenanthrene: from the orchid Scaphyglottis livida; structure in first source		2.7730
batatasin-iii
[no description available]		2.5320stilbenoid
idelalisib
idelalisib: an antineoplastic agent and p110delta inhibitor; structure in first source. idelalisib : A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.		2.1310aromatic amine;
organofluorine compound;
purines;
quinazolines;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
minocycline
Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.		2.2110
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		3.1550
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma, Non-Small Cell Lung
[description not available]		02.3110
Cancer of Lung
[description not available]		02.3110
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.3110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.3110