Compounds > trispheridine
Page last updated: 2024-12-08

trispheridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

trispheridine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID443684
CHEMBL ID511443
CHEBI ID32266
MeSH IDM0434546

Synonyms (13)

Synonym
(1,3)dioxolo(4,5-j)phenathridine
[1,3]dioxolo[4,5-j]phenanthridine
trisphaeridine
224-11-3
trispheridine
CHEMBL511443 ,
chebi:32266 ,
AC1L9EZZ ,
8,9-(methylenedioxy)phenanthridine
phenanthridine, 8,9-[methylenebis(oxy)]-
RFILRSDHWIIIMN-UHFFFAOYSA-N
DTXSID10176927
Q27114842
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenanthridinesAny dibenzopyridine based on the skeleton of phenanthridine and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID402988Inhibition of LPS-induced NO production in ddY mouse macrophages at 1 uM after 20 hrs by Griess reagent assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID402992Inhibition of LPS-induced NO production in ddY mouse macrophages at 10 uM after 20 hrs by Griess reagent assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID402989Cytotoxicity against mouse ddY macrophages assessed as cell viability at 1 um after 72 hrs by MTT assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID718093Cytotoxicity against human K562 cells after 48 hrs by MTT assay2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Cytotoxic alkaloids from the whole plants of Zephyranthes candida.
AID402995Cytotoxicity against mouse ddY macrophages assessed as cell viability at 30 um after 72 hrs by MTT assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID718090Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Cytotoxic alkaloids from the whole plants of Zephyranthes candida.
AID402997Cytotoxicity against mouse ddY macrophages assessed as cell viability at 100 um after 72 hrs by MTT assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID718094Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Cytotoxic alkaloids from the whole plants of Zephyranthes candida.
AID725732Inhibition of human recombinant topoisomerase 1-mediated relaxation of supercoiled pUC18 plasmid DNA in human MCF7 cells nuclear extracts at 100 uM after 30 mins by ethidium bromide staining based gel electrophoresis analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs.
AID402990Inhibition of LPS-induced NO production in ddY mouse macrophages at 3 uM after 20 hrs by Griess reagent assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID402996Inhibition of LPS-induced NO production in ddY mouse macrophages at 100 uM after 20 hrs by Griess reagent assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID402993Cytotoxicity against mouse ddY macrophages assessed as cell viability at 10 um after 72 hrs by MTT assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID725733Growth inhibition of human GXF251L cells after 72 hrs by SRB assay2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs.
AID718091Cytotoxicity against human A549 cells after 48 hrs by MTT assay2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Cytotoxic alkaloids from the whole plants of Zephyranthes candida.
AID718092Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay2012Journal of natural products, Dec-28, Volume: 75, Issue:12
Cytotoxic alkaloids from the whole plants of Zephyranthes candida.
AID402994Inhibition of LPS-induced NO production in ddY mouse macrophages at 30 uM after 20 hrs by Griess reagent assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
AID402991Cytotoxicity against mouse ddY macrophages assessed as cell viability at 3 um after 72 hrs by MTT assay relative to control2004Journal of natural products, Jul, Volume: 67, Issue:7
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's7 (77.78)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.34 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzaldehyde
[no description available]		2.0510hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
pyridine
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.		3.2310azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines		environmental contaminant;
NMR chemical shift reference compound
phenanthridone
phenanthridone: coal tar derivative; structure given in first source. phenanthridone : A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.		2.0810lactam;
phenanthridines		EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
immunosuppressive agent;
mutagen
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.0110aromatic ether;
nitrile;
polyether;
tertiary amino compound
bis(2-guanidinoethyl)disulfide
bis(2-guanidinoethyl)disulfide: bifunctional cation; RN given refers to parent cpd; structure		2.0210
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		2.0510glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		3.2310pyrrole;
secondary amine
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		3.2310azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
isothiocyanic acid
[no description available]		2.1110hydracid;
one-carbon compound
rutecarpine
rutacarpine: from Evodia rutaecarpa; an ingredient in zhuyu hewei zhitong capsules		3.2310beta-carbolines
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.		3.1450indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
pretazettine
pretazettine: potent inhibitor of viral reverse transcriptase; narcissus alkaloid; prolongs life of leukemic mice; RN given refers to (6a beta,8 beta)-isomer; structure		2.0110alkaloid
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.0210amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
ungeremine
ungeremine: RN given refers to parent cpd; structure		2.0810
hemanthamine
[no description available]		2.0710alkaloid
hemanthidine
hemanthidine: crinine-like alkaloid from AMARYLLIDACEAE		2.0110
caffeic acid phenethyl ester
phenethyl caffeate : An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.		2.0210alkyl caffeate esteranti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiviral agent;
immunomodulator;
metabolite;
neuroprotective agent
tazettine
tazettine: from Amaryllidaceae		2.4420indole alkaloid fundamental parent;
indole alkaloid
herbimycin
[no description available]		2.0210
luotonin a
luotonin A: structure in first source		3.2310quinazolines
nifedipine
hemanthamine: crinine-like alkaloid from AMARYLLIDACEAE; RN given for (3beta,5alpha,11R,13beta,19alpha)-isomer; structure in first source		2.4320
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Prostate
[description not available]		02.0810
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0810
Leukemia L5178
An experimental lymphocytic leukemia of mice.		02.0110