15-Hydroperoxyabietic acid (15-HPAA) is a **naturally occurring organic compound** that belongs to the **abietane diterpenoid** family. It is derived from **abietic acid**, a major constituent of **rosin**, a sticky substance found in pine trees.
**Here's why 15-HPAA is important in research:**
* **Biological Activity:** 15-HPAA exhibits a wide range of biological activities, including:
* **Antioxidant properties:** It can scavenge free radicals, protecting cells from oxidative damage.
* **Anti-inflammatory effects:** It can inhibit the production of inflammatory mediators like prostaglandins.
* **Anti-cancer activity:** Studies suggest it may have potential to inhibit the growth of certain cancer cells.
* **Antimicrobial effects:** It shows activity against some bacteria and fungi.
* **Potential Applications:** Due to its diverse biological activities, 15-HPAA has garnered interest for its potential applications in:
* **Pharmaceutical development:** As a potential therapeutic agent for treating various diseases.
* **Cosmetics and personal care products:** For its antioxidant and anti-inflammatory properties.
* **Food preservation:** As a natural antimicrobial agent.
* **Research Interest:** 15-HPAA has sparked significant research interest due to:
* **Structure-activity relationship:** Researchers are investigating the relationship between its structure and biological activity.
* **Mechanisms of action:** Understanding how 15-HPAA exerts its effects on cells and biological systems.
* **Synthesis and modification:** Exploring new methods for synthesizing and modifying 15-HPAA to enhance its therapeutic potential.
**It's important to note:**
* 15-HPAA research is still in its early stages, and much remains to be learned about its safety and efficacy.
* More research is needed to fully understand its potential benefits and risks before it can be widely used in clinical or commercial applications.
In summary, 15-HPAA is a natural compound with promising biological activities, making it a significant focus of research for potential applications in various fields, including pharmaceuticals, cosmetics, and food preservation. However, further investigation is required to validate its safety and efficacy before widespread use.
15-hydroperoxyabietic acid: isolated from Portuguese colophony of gum rosin; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 163916 |
| MeSH ID | M0156968 |
| Synonym |
|---|
| 113903-96-1 |
| 15-hydroperoxyabietic acid |
| methyl (1r,4ar,4br,10ar)-7-(2-hydroperoxypropan-2-yl)-4a-methyl-2,3,4,4b,5,6,10,10a-octahydro-1h-phenanthrene-1-carboxylate |
| unii-08y6de8i1u |
| 08y6de8i1u , |
| 1-phenanthracenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-7-(1-hydroperoxy-1-methylethyl)-1,4a-dimethyl-, (1r-(1alpha,4abeta,4betaalpha,10aalpha))- |
| 15-hpa |
| 1-phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-7-(1-hydroperoxy-1-methylethyl)-1,4a-dimethyl-, (1r,4ar,4br,10ar)- |
| 1-phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-7-(1-hydroperoxy-1-methylethyl)-1,4a-dimethyl-, (1r-(1.alpha.,4a.beta.,4b.alpha.,10a.alpha.))- |
| methyl 7-(2-hydroperoxypropan-2-yl)-4a-methyl-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylate |
| DTXSID70921238 |
| Q27236431 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.80) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||