Compounds > rosettacin
Page last updated: 2024-11-13

rosettacin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rosettacin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24813913
CHEMBL ID110203
SCHEMBL ID4374000
MeSH IDM0521314

Synonyms (4)

Synonym
rosettacin
CHEMBL110203
SCHEMBL4374000
3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15,17,19-nonaen-14-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID366204Antiproliferative activity against human OVCAR-3 cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID453802Cytotoxicity against human OVCAR-3 cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID102147Cytotoxic concentration against human breast MDA-MB-435 cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID453803Cytotoxicity against human SN12C cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID200453Cytotoxic concentration against human renal SN12C cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID366208Inhibition of human recombinant topoisomerase 1 assessed as DNA cleavage relative to 1 uM camptothecin2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID497142Cytotoxicity against human UACC62 cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID366201Antiproliferative activity against human HCT116 cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID453804Cytotoxicity against human DU145 cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID497136Cytotoxicity against human HOP62 cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID497146Cytotoxicity against human SN12C cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID366202Antiproliferative activity against human SF539 cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID214746Cytotoxic concentration against human melanoma UACC-62 cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID366207Antiproliferative activity against human MDA-MB-435 cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID497150Cytotoxicity against human MCF7 cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID57725Cytotoxic concentration against human prostate DU-145 cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID497138Cytotoxicity against human HCT116 cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID366200Antiproliferative activity against human HOP62 cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID497144Cytotoxicity against human OVCAR-3 cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID453805Cytotoxicity against human MDA-MB-435 cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID453798Cytotoxicity against human HOP62 cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID453799Cytotoxicity against human HCT116 cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID46084Cytotoxic concentration against human CNS SF-539 cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID46746Mean graph midpoint for growth inhibition of all human cancer cell lines2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID80526Cytotoxic concentration against human colon HCT116 cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID453800Cytotoxicity against human SF539 cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID497153Inhibition of human recombinant Top1-mediated DNA cleavage at 0.1 to 100 uM after 20 mins relative to camptothecin2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID145418Cytotoxic concentration against human ovarian OVCAR-3 cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID453801Cytotoxicity against human UACC62 cells2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID56716Activity to produce DNA topoisomerase I-mediated DNA cleavage at concentration up to 10 uM; ++, indicates similar activity as the parent compound 22003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID81501Cytotoxic concentration against human lung HOP-62 cell line growth inhibition2003Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
AID366206Antiproliferative activity against human DU145 cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID497148Cytotoxicity against human DU145 cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID453806Inhibition of human DNA topoisomerase 1 assessed as induction of enzyme-dependent DNA cleavage relative to 1 uM camptothecin2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.
AID366205Antiproliferative activity against human SN12C cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
AID497140Cytotoxicity against human SF539 cells2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.
AID366203Antiproliferative activity against human UACC62 cells2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.5120elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		2.1510monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
rhodium
Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.		7.0710cobalt group element atom
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.7430delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
1,7-phenanthroline
[no description available]		2.0710phenanthroline
cryptolepine
cryptolepine: fused indole-quinoline; structure in first source; from CRYPTOLEPIS sanguinolenta. cryptolepine : An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group.		2.2110indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound		anti-inflammatory agent;
antimalarial;
antineoplastic agent;
cysteine protease inhibitor;
plant metabolite
tylophorine
tylophorine: phenanthroindolizidine alkaloid		7.0710organic heteropentacyclic compound;
organonitrogen heterocyclic compound
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.1510cobalt group element atom;
metal allergen		micronutrient
protoberberine
protoberberine: a benzyltetrahydroisoquinoline derivative that appears as an isoquinoline annelated (adjoined) with a naphthylene; the nitrogen is typically quarternary; nitidine is annelated differently; RN given refers to parent cpd		2.1510
nsc 314622
NSC 314622: structure in first source		2.7230
nsc 706744
[no description available]		2.7430
antofine
antofine: structure in first source. (-)-antofine : An organic heteropentacyclic compound that is (13aR)-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups. It is an alkaloid produced by relatives of the milkweed family and exhibits antiviral, anti-inflammatory, antiadipogenic and antitumorigenic activities.		7.0710alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound		angiogenesis inhibitor;
anti-inflammatory agent;
antimicrobial agent;
antineoplastic agent;
antiviral agent;
phytotoxin;
plant metabolite
22-hydroxyacuminatine
22-hydroxyacuminatine: cytotoxic; isolated from Camptotheca acuminata; structure in first source		2.0410
septicine
septicine: structure in first source		7.0710
nsc 725776
NSC 725776: inhibits topoisomerase I; structure in first source		2.0510
nsc 724998
[no description available]		2.0510
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
African Sleeping Sickness
[description not available]		02.1710
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.		02.1710
Experimental Neoplasms
[description not available]		02.2110