| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
4-phenyl-3-furoxancarbonitrile
4-phenyl-3-furoxancarbonitrile: structure given in first source. 4-phenyl-3-furoxancarbonitrile : A 1,2,5-oxadiazole substituted by an oxido, cyano and phenyl groups at positions 2, 3 and 4, respectively. It is a vasodilator and inhibitor of platelet aggregation. | 3.35 | 1 | 0 | 1,2,5-oxadiazole;
benzenes;
N-oxide;
nitrile | geroprotector;
nitric oxide donor;
platelet aggregation inhibitor;
soluble guanylate cyclase activator;
vasodilator agent |
amodiaquine
Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.. amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position. | 2.38 | 2 | 0 | aminoquinoline;
organochlorine compound;
phenols;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
drug allergen;
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor;
non-steroidal anti-inflammatory drug;
prodrug |
cgs 15943
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine: non-xanthine triazoloquinazoline adenosine antagonist. CGS 15943 : A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors. | 3.35 | 1 | 0 | aromatic amine;
biaryl;
furans;
organochlorine compound;
primary amino compound;
quinazolines;
triazoloquinazoline | adenosine A1 receptor antagonist;
adenosine A2A receptor antagonist;
antineoplastic agent;
central nervous system stimulant |
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. | 2.89 | 4 | 0 | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug |
cl 387785
CL 387785: structure in first source. N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide : A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group at position 6 has been replaced by a but-2-ynoyl group. | 3.35 | 1 | 0 | bromobenzenes;
quinazolines;
secondary carboxamide;
ynamide | antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
epidermal growth factor receptor antagonist |
oxamniquine
Oxamniquine: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121). oxamniquine : A racemate comprising equimolar amounts of (R)- and (S)-oxamniquine. An anthelmintic, it is administered orally for the treatment of schistomiasis caused by Schistosoma mansoni (but not by other Schistosoma species); intramuscular administration is no longer used as it causes severe pain at the injection site.. {2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol : A member of the class of quinolines that is 1,2,3,4-tetrahydroquinoline which is substituted at positions 2, 6, and 7 by (isopropylamino)methyl, hydroxymethyl, and nitro groups, respectively. | 3.35 | 1 | 0 | aromatic primary alcohol;
C-nitro compound;
quinolines;
secondary amino compound | |
praziquantel
azinox: Russian drug | 3.35 | 1 | 0 | isoquinolines | |
pyrimethamine
Maloprim: contains above 2 cpds | 2.38 | 2 | 0 | aminopyrimidine;
monochlorobenzenes | antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
wr 30090
WR 30090: RN given refers to parent cpd without isomeric designation; structure | 1.98 | 1 | 0 | | |
halofantrine
halofantrine: used in treatment of mild to moderate acute malaria | 8.36 | 7 | 0 | phenanthrenes | |
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. | 1.97 | 1 | 0 | organic peroxide;
sesquiterpene lactone | antimalarial;
plant metabolite |
mmv665852
MMV665852: an antischistosomal agent | 3.35 | 1 | 0 | | |
gr 127935
GR 127935: a 5-HT 1D receptor antagonist. GR 127935 : A member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid and the anilino group of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration. | 3.35 | 1 | 0 | 1,2,4-oxadiazole;
benzamides;
N-alkylpiperazine;
N-arylpiperazine | |
parthenolide
[no description available] | 3.35 | 1 | 0 | germacranolide | |
1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol
1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol: structure given in first source | 1.99 | 1 | 0 | | |
wr 99210
BRL 6231: RN given refers to parent cpd; NM & N1 refer to HCl; synonym BRL 51084 refers to (mono-HBr); structure | 1.97 | 1 | 0 | | |
wr 194965
WR 194965: structure given in first source | 2.66 | 3 | 0 | | |
wr 184806
WR 184806: internal std for chromatographic anal of mefluquine; RN given refers to (+-)-isomer; structure given in first source | 2.38 | 2 | 0 | | |
gw 3965
GW 3965: a liver X receptor ligand | 3.35 | 1 | 0 | diarylmethane | |
cardamonin
cardamonin: found in Zingiberaceae; structure in first source | 3.35 | 1 | 0 | chalcones | |
sesquiterpenes
[no description available] | 1.97 | 1 | 0 | | |
stattic
[no description available] | 3.35 | 1 | 0 | 1-benzothiophenes;
C-nitro compound;
sulfone | antineoplastic agent;
radiosensitizing agent;
STAT3 inhibitor |
quinine
[no description available] | 2.66 | 3 | 0 | cinchona alkaloid | antimalarial;
muscle relaxant;
non-narcotic analgesic |
rs 17053
[no description available] | 3.35 | 1 | 0 | indoles | |
licochalcone a
licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer | 3.35 | 1 | 0 | chalcones | |
2'-hydroxy-4-methoxychalcone
[no description available] | 3.35 | 1 | 0 | | |
aldosterone
dehydrodiisoeugenol: an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages; structure in first source | 3.35 | 1 | 0 | | |
ekb 569
EKB 569: an EGF receptor kinase inhibitor | 3.35 | 1 | 0 | aminoquinoline;
monocarboxylic acid amide;
monochlorobenzenes;
nitrile | protein kinase inhibitor |
ispinesib
[no description available] | 3.35 | 1 | 0 | benzamides | |
1,2,6,7-tetraoxaspiro(7.11)nonadecane
1,2,6,7-tetraoxaspiro(7.11)nonadecane: structure in first source | 3.35 | 1 | 0 | | |
sd-208
[no description available] | 3.35 | 1 | 0 | | |
bi 2536
[no description available] | 3.35 | 1 | 0 | | |
alpha-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol
alpha-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol: structure | 2.67 | 3 | 0 | | |
mefloquine
Mefloquine: A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.. mefloquine : A racemate composed of (+)-(11R,2'S)- and (-)-(11S,2'R)-enantiomers of mefloquine. An antimalarial agent which acts as a blood schizonticide; its mechanism of action is unknown. | 3.6 | 9 | 0 | | |
bms-833923
BMS-833923: an Smo inhibitor | 3.35 | 1 | 0 | | |
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof. | 3.36 | 7 | 0 | | |