cassaine: Erythrophleum alkaloid; RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cassaine : A tricyclic diterpenoid isolated from several plant species of the genus Erythrophleum. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Erythrophleum | genus | [no description available] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 5281267 |
| CHEMBL ID | 2010022 |
| CHEBI ID | 3454 |
| MeSH ID | M0056408 |
| Synonym |
|---|
| nsc-72302 |
| cassaine |
| C08670 , |
| 468-76-8 |
| AC1NQYAR , |
| nsc 72302 |
| acetic acid, (dodecahydro-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-2(1h)-phenanthrenylidene)-, 2-(dimethylamino)ethyl ester, (1r-(1alpha,2e,4aalpha,4bbeta,7beta,8aalpha,10abeta))- |
| (e)-3beta-hydroxy-14alpha-methyl-7-oxopodocarpane-delta13alpha-acetic acid 2-(dimethylamino)-ethyl ester |
| hsdb 3547 |
| unii-pqk203c49t |
| podocarpane-delta(13,alpha)-acetic acid, 3beta-hydroxy-14alpha-methyl-7-oxo-, 2-(dimethylamino)ethyl ester, (e)- |
| pqk203c49t , |
| (dodecahydro-7beta-hydroxy-1alpha,4bbeta,8,8-tetramethyl-10-oxo-2(1h)-phenanthrenylidene)acetic acid 2-(dimethylamino)ethyl ester |
| nervocidine |
| cassaine [mi] |
| (-)-cassaine |
| (2e)-((1r,4as,4br,7s,8ar,10as)-dodecahydro-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-2(1h)-phenanthrenylidene)acetic acid 2-(dimethylamino)ethyl ester |
| acetic acid, ((1r,4as,4br,7s,8ar,10as)-dodecahydro-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-2(1h)-phenanthrenylidene)-, 2-(dimethylamino)ethyl ester, (2e)- |
| 2-(dimethylamino)ethyl (2e)-[(13e)-3beta-hydroxy-14alpha-methyl-7-oxopodocarpan-13-ylidene]acetate |
| (+)-cassaine |
| CHEBI:3454 , |
| CHEMBL2010022 |
| 2-(dimethylamino)ethyl (2e)-2-[(1r,4as,4br,7s,8ar,10as)-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-1,3,4,4a,5,6,7,8a,9,10a-decahydrophenanthren-2-ylidene]acetate |
| Q19903766 |
| AKOS040751041 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| cardiotonic drug | A drug that has a strengthening effect on the heart or that can increase cardiac output. |
| local anaesthetic | Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block. |
| antihypertensive agent | Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| poison | Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism. |
| EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor | An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of Na(+)/K(+)-transporting ATPase (EC 3.6.3.9). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| tricyclic diterpenoid | Any diterpenoid with a tricyclic skeleton. |
| tertiary amino compound | A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups. |
| enoate ester | An alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position. |
| organic hydroxy compound | An organic compound having at least one hydroxy group attached to a carbon atom. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 7 (31.82) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 9 (40.91) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.39) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 23 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||