Page last updated: 2024-12-06
juncusol
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
juncusol: cytotoxic dihydro phenanthrene from Estuarian marsh plant Juncus roemerianus; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Juncus | genus | [no description available] | Juncaceae | [no description available] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 72740 |
| CHEMBL ID | 38650 |
| SCHEMBL ID | 10477036 |
| MeSH ID | M0062306 |
Synonyms (25)
| Synonym |
|---|
| juncusol |
| NSC220968 , |
| 2, 5-ethenyl-9,10-dihydro-1,6-dimethyl- |
| nsc-220968 |
| 62023-90-9 |
| NCI60_001834 |
| CHEMBL38650 , |
| 1,6-dimethyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol |
| 5-ethenyl-1,6-dimethyl-9,10-dihydrophenanthrene-2,7-diol |
| 1,6-dimethyl-5-vinyl-9,10-dihydro-phenanthrene-2,7-diol |
| 2,7-phenanthrenediol, 5-ethenyl-9,10-dihydro-1,6-dimethyl- |
| 6t481hu7oi , |
| nsc 220968 |
| unii-6t481hu7oi |
| SCHEMBL10477036 |
| DTXSID70211080 |
| 2,7-dihydroxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthrene |
| 5-ethenyl-9,10-dihydro-1,6-dimethyl-2,7-phenanthrenediol |
| Q18386250 |
| FT-0775763 |
| bdbm50537502 |
| CS-0032470 |
| HY-N5126 |
| AKOS040760494 |
| FS-7129 |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " Juncusol was ten times more toxic to the various species of fish than to grass shrimp." | ( Toxic effects of juncusol, a marsh plant phenolic extract, on estuarine fish and shrimp. Chapatwala, KD; de la Cruz, AA; Miles, DH, 1982) | 1.51 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 8 | Homo sapiens (human) | IC50 (µMol) | 6.5000 | 4.9300 | 7.3900 | 9.9200 | AID1639438 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (7)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| monoatomic ion transport | Solute carrier family 22 member 8 | Homo sapiens (human) |
| response to toxic substance | Solute carrier family 22 member 8 | Homo sapiens (human) |
| inorganic anion transport | Solute carrier family 22 member 8 | Homo sapiens (human) |
| prostaglandin transport | Solute carrier family 22 member 8 | Homo sapiens (human) |
| xenobiotic transport | Solute carrier family 22 member 8 | Homo sapiens (human) |
| transmembrane transport | Solute carrier family 22 member 8 | Homo sapiens (human) |
| transport across blood-brain barrier | Solute carrier family 22 member 8 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Molecular Functions (4)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| solute:inorganic anion antiporter activity | Solute carrier family 22 member 8 | Homo sapiens (human) |
| organic anion transmembrane transporter activity | Solute carrier family 22 member 8 | Homo sapiens (human) |
| prostaglandin transmembrane transporter activity | Solute carrier family 22 member 8 | Homo sapiens (human) |
| xenobiotic transmembrane transporter activity | Solute carrier family 22 member 8 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (4)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Solute carrier family 22 member 8 | Homo sapiens (human) |
| basolateral plasma membrane | Solute carrier family 22 member 8 | Homo sapiens (human) |
| apical plasma membrane | Solute carrier family 22 member 8 | Homo sapiens (human) |
| extracellular exosome | Solute carrier family 22 member 8 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Bioassays (14)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1639438 | Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assay | 2019 | Journal of natural products, 04-26, Volume: 82, Issue:4 | Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3. |
| AID103866 | In vitro antimicrobial activity against Mycobacterium smegmatis ATCC 607 tested at 25-0.1 ug/mL | 1985 | Journal of medicinal chemistry, Oct, Volume: 28, Issue:10 | Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. |
| AID95072 | In vitro cytotoxic activity against L-1210 mouse lymphocytic leukemia cell culture (ATCC CCL-219) | 1985 | Journal of medicinal chemistry, Oct, Volume: 28, Issue:10 | Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. |
| AID1639435 | Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake at 50 uM measured after 5 mins by fluorescence assay relative to control | 2019 | Journal of natural products, 04-26, Volume: 82, Issue:4 | Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3. |
| AID42702 | In vitro antimicrobial activity against Candida albicans ATCC 10231 tested at 25-0.1 ug/mL; i=Inactive at highest concentration | 1985 | Journal of medicinal chemistry, Oct, Volume: 28, Issue:10 | Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. |
| AID1435549 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by microdilution method | 2016 | Journal of natural products, 11-23, Volume: 79, Issue:11 | Phenanthrenes from Juncus inflexus with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus. |
| AID38201 | In vitro cytotoxic activity against B-16 mouse melanoma (B-16) | 1985 | Journal of medicinal chemistry, Oct, Volume: 28, Issue:10 | Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. |
| AID641626 | Inhibition of Mycobacterium tuberculosis RmlD assessed as inhibition of dTDP-beta-6-deoxy-L-lyxo-4-hexulose to dTDP-beta-L-rhamnose conversion at 10 ug/ml | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23 | Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening. |
| AID94155 | In vitro antimicrobial activity against Klebsiella pneumoniae ATCC 10031 tested at 25-0.1 ug/mL; i=Inactive at highest concentration | 1985 | Journal of medicinal chemistry, Oct, Volume: 28, Issue:10 | Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. |
| AID1435548 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 at 10 mg/ml after 24 hrs by disk diffusion method | 2016 | Journal of natural products, 11-23, Volume: 79, Issue:11 | Phenanthrenes from Juncus inflexus with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus. |
| AID89834 | In vitro cytotoxic activity against, human lymphoblastic leukemia cell culture (CCRF-CEM); nt=Not tested | 1985 | Journal of medicinal chemistry, Oct, Volume: 28, Issue:10 | Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. |
| AID1639436 | Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake at 50 uM measured after 5 mins by fluorescence assay relative to control | 2019 | Journal of natural products, 04-26, Volume: 82, Issue:4 | Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3. |
| AID201093 | In vitro antimicrobial activity against, Staphylococcus aureus ATCC 13709 tested at 25-0.1 ug/mL | 1985 | Journal of medicinal chemistry, Oct, Volume: 28, Issue:10 | Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. |
| AID1435551 | Ratio of MIC for methicillin-sensitive Staphylococcus aureus in dark to MIC for methicillin-sensitive Staphylococcus aureus in presence of UVA irradiation | 2016 | Journal of natural products, 11-23, Volume: 79, Issue:11 | Phenanthrenes from Juncus inflexus with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (13)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.75
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.75) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||