Compounds > n-hydroxy-4-acetylaminobiphenyl
Page last updated: 2024-12-06

n-hydroxy-4-acetylaminobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-hydroxy-4-acetylaminobiphenyl: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N-hydroxy-4-acetylaminobiphenyl : A hydroxamic acid that is biphenyl-4-amine bearing N-hydroxy and N-acetyl substituents. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID20527
CHEMBL ID279548
CHEBI ID16434
SCHEMBL ID3345880
MeSH IDM0041512

Synonyms (30)

Synonym
n-hydroxy-4-acetamidodiphenyl
n-hydroxy-n-4-biphenylacetamide
n-([1,1'-biphenyl]-4-yl)-n-hydroxyacetamide
n-(4-biphenylyl)acetohydroxamic acid
n-4-biphenylylacetohydroxamic acid
n-acetyl-4-biphenylhydroxylamine
n-hydroxy-4-acetamidobiphenyl
CHEBI:16434 ,
acetamide, n-(1,1'-biphenyl)-4-yl-n-hydroxy-
n-4-(n-hydroxyacetamido)biphenyl
acetohydroxamic acid, n-4-biphenylyl-
4-biphenylacethydroxamic acid
ccris 1061
n-(1,1'-biphenyl)-4-yl-n-hydroxyacetamide
brn 2807692
n-acetyl-n-hydroxy-4-aminobiphenyl
n-hydroxy-4-(acetylamino)biphenyl
n-hydroxy-4-acetylaminobiphenyl
C04081
4463-22-3
n-hydroxy-n-4-acetylaminobiphenyl
n-hydroxy-n-(4-phenylphenyl)-acetamide
CHEMBL279548
SCHEMBL3345880
n-[1,1'-biphenyl]-4-yl-n-hydroxyacetamide #
UNHSJQXRZCIATF-UHFFFAOYSA-N
4-acetamido-n-hydroxybiphenyl
acetamide, n-[1,1'-biphenyl]-4-yl-n-hydroxy-
DTXSID7020718
Q27101903

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" BPDE was about 1000-fold more toxic and mutagenic than N-OH-AABP in TK6 cells on a molar basis."( Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity.
Fan, W; Jing, L; Luo, W; Ricicki, E; Vouros, P; Xie, H; Zarbl, H; Zhao, LP, 2005)		0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxamic acidA compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID39229Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with partially purified hepatic enzyme in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID143757Inhibition of AHAT-catalyzed transacylation of 4-aminoazobenzene1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
N-arylhydroxamic acid N,O-acyltransferase. Positional requirements for the substrate hydroxyl group.
AID85005Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using N-ethyl maleimide as inhibitor (1.0 mM) in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID39227Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with hamster hepatic enzyme after dialysis1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID168097Carcinogenic activity on mixed data after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID167927Carcinogenic activity on all sites after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID84141Effect for methylthio adduct formation in presence of 0.1 mM N-hydroxy-4-aminobiphenyl and 10 mM N-acetylmethioninein hamster hepatic AHAT preparation at 30 min1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID227347Compound inhibit the AHAT-catalyzed transacetylation activity; Active1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID227171AHAT-catalyzed transacetylation rate at 0.5-1.0 concentration1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID39230Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with partially purified hepatic enzyme in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID167939Carcinogenic activity on breast after oral administration of the compound1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID167955Carcinogenic activity on ear duct after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID168110Carcinogenic activity on other sites after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID171629Transacetylation rate in rat hepatic AHAT preparation1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID85004Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using 4-chloro mercuri benzenesulfonate as inhibitor (1.0 mM) in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID183000Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using iodo acetamide as inhibitor (1.0 mM) in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID39228Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with hamster hepatic enzyme before dialysis1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID85006Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using iodo acetamide as inhibitor (1.0 mM) in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID182999Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using N-ethyl maleimide as inhibitor (1.0 mM) in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID168085Carcinogenic activity on liver after oral administration of the compound1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID84162Transacetylation rate in hamster hepatic AHAT preparation1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID182998Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using 4-chloro mercuri benzenesulfonate as inhibitor (1.0 mM) in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (29)

TimeframeStudies, This Drug (%)All Drugs %
pre-199013 (44.83)18.7374
1990's9 (31.03)18.2507
2000's5 (17.24)29.6817
2010's2 (6.90)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.78 (24.57)
Research Supply Index3.40 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
butyraldehyde
[no description available]		1.9810butanalsbiomarker;
Escherichia coli metabolite;
mouse metabolite
pentachlorophenol
PENTA: structure given in first source		1.9710aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes		human xenobiotic metabolite
2-aminofluorene
[no description available]		2.6530
amitrole
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.		1.9610aromatic amine;
triazoles		carotenoid biosynthesis inhibitor;
EC 1.11.1.6 (catalase) inhibitor;
herbicide
acetohydroxamic acid
acetohydroxamic acid: urease inhibitor. oxime : Compounds of structure R2C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes.. N-hydroxyacetimidic acid : A carbohydroximic acid consisting of acetimidic acid having a hydroxy group attached to the imide nitrogen.. acetohydroxamic acid : A member of the class of acetohydroxamic acids that is acetamide in which one of the amino hydrogens has been replaced by a hydroxy group.		1.9610acetohydroxamic acids;
carbohydroximic acid		algal metabolite;
EC 3.5.1.5 (urease) inhibitor
azathioprine
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed). azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.		1.9610aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug
iodoacetamide
[no description available]		1.9610
ethylmaleimide
Ethylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.		1.9610maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
phenacetin
Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione		2.3820acetamides;
aromatic ether		cyclooxygenase 3 inhibitor;
non-narcotic analgesic;
peripheral nervous system drug
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		1.9610barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
suramin
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.		1.9610naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
piperonyl butoxide
[no description available]		1.9510benzodioxolespesticide synergist
n-hydroxy-2-aminofluorene
N-hydroxy-2-aminofluorene: structure		2.3620
hydroxyacetylaminofluorene
Hydroxyacetylaminofluorene: A N-hydroxylated derivative of 2-ACETYLAMINOFLUORENE that has demonstrated carcinogenic action.		3.751102-acetamidofluorenes
2-acetylaminofluorene
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.		3.21602-acetamidofluorenesantimitotic;
carcinogenic agent;
epitope;
mutagen
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		1.9510ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
p-aminoazobenzene
p-Aminoazobenzene: Used in the form of its salts as a dye and as an intermediate in manufacture of Acid Yellow, diazo dyes, and indulines.. 4-(phenylazo)aniline : Azobenzene substituted at one of the 4-positions by an amino group. It has a role as a dye and an allergen.		2.3720
1-phenylazo-2-naphthylamine
[no description available]		1.9610
2-naphthylamine
2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2.		2.3620naphthylaminecarcinogenic agent
3,3'-dichlorobenzidine
3,3'-Dichlorobenzidine: A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species.		1.9610biphenyls;
monochlorobenzenes;
organochlorine compound
4-biphenylamine
4-biphenylamine: used in detection of sulfates, & as a carcinogen in cancer research; RN given refers to parent cpd; structure. biphenyl-4-amine : An aminobiphenyl that is biphenyl substituted by an amino group at position 4.		2.9140aminobiphenylcarcinogenic agent
benzidine
benzidine: RN given refers to parent cpd. benzidine : A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.		1.9610biphenyls;
substituted aniline		carcinogenic agent
o-aminoazotoluene
o-Aminoazotoluene: An azo dye with carcinogenic properties.		1.9610
methylenebis(chloroaniline)
Methylenebis(chloroaniline): Aromatic diamine used in the plastics industry as curing agent for epoxy resins and urethane rubbers. It causes bladder, liver, lung, and other neoplasms.. 4,4'-methylene-bis-(2-chloroaniline) : A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge.		1.9610chloroanilinemetabolite
4,4'-diaminodiphenylmethane
4,4'-diaminodiphenylmethane: RN given refers to parent cpd; structure. 4,4'-diaminodiphenylmethane : An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.		1.9610aromatic amineallergen;
carcinogenic agent
2-tolidine
2-tolidine: RN given refers to parent cpd; structure		1.9610biphenyls
yellow ob
[no description available]		1.9610
2,7-diacetylaminofluorene
2,7-diacetylaminofluorene: has been found to induce leukemia in animals; minor descriptor (75-84); on-line search 2-ACETYLAMINOFLUORENE/AA (75-84); Index Medicus search 2-ACETYLAMINOFLUORENE/AA (80-82), FLUORENES (75-79)		1.9610
paraoxon
[no description available]		1.9610aryl dialkyl phosphate;
organophosphate insecticide		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
mouse metabolite
2,7-fluorenediamine
2,7-fluorenediamine: peroxidase reagent for blood smears; RN given refers to parent cpd		1.9610
n-hydroxy-1-naphthylamine
N-hydroxy-1-naphthylamine: carcinogen		1.9610N-substituted amine
1-aminoanthracene
[no description available]		1.9610anthracenamine
2-anthramine
2-anthramine: structure		1.9610anthracenamine
4,4'-methylene bis(2-methylaniline)
4,4'-methylene bis(2-methylaniline): structure		1.9610diarylmethane
n-hydroxy-4-acetylaminostilbene
N-hydroxy-4-acetylaminostilbene: structure		1.9710
9-aminophenanthrene
[no description available]		1.9610phenanthrenamine
dithiothreitol
1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.		1.96101,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent
3-methoxy-4-aminoazobenzene
[no description available]		1.9610
n-hydroxy-n-(2-fluorenyl)benzamide
N-hydroxy-N-(2-fluorenyl)benzamide: structure given in first source		1.9610
4-acetylaminobiphenyl
[no description available]		2.6530biphenyls
2-acetamidophenanthrene
[no description available]		1.9610
acetoxyacetylaminofluorene
Acetoxyacetylaminofluorene: An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action.. N-acetoxy-2-acetamidofluorene : A 2-acetamidofluorene compound in which the parent 2-acetamidofluorene is substituted on nitrogen by an acetoxy group.		1.96102-acetamidofluorenescarcinogenic agent;
mutagen
3-acetylaminofluorene
3-acetylaminofluorene: non-carcinogenic structural isomer of carcinogen N-2-fluorenylacetamide		1.9610
2',3-dimethyl-4-aminobiphenyl
2',3-dimethyl-4-aminobiphenyl: RN given refers to parent cpd; structure		1.9610
n-hydroxyphenacetin
N-hydroxyphenacetin: RN given refers to parent cpd; structure		2.3820
fanft
FANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.		1.9610
N-fluorenylacetamide
[no description available]		1.9610fluorenes
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.		2.0210epoxideintercalator
acridine orange
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.. acridine orange : Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.. acridine orange free base : A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.		1.9610aminoacridines;
aromatic amine;
tertiary amino compound		fluorochrome;
histological dye
n-hydroxy-2-naphthylamine
[no description available]		2.3620
n-hydroxy-4-aminobiphenyl
[no description available]		8.0850aminobiphenyl;
N-substituted amine		carcinogenic agent;
human xenobiotic metabolite
n-acetoxy-4-acetylaminobiphenyl
[no description available]		7.6730
7-iodo-n-2-acetylaminofluorene
[no description available]		1.9610
n-hydroxy-4-aminoazobenzene
N-hydroxy-4-aminoazobenzene: RN given refers to parent cpd		1.9610
acetyl coenzyme a
Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.		1.9810acyl-CoAacyl donor;
coenzyme;
effector;
fundamental metabolite
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		1.9710stilbene
4-dimethylaminostilbene
4-dimethylaminostilbene: RN given refers to cpd without isomeric designation; structure		1.9610
4-acetylaminostilbene
4-acetylaminostilbene: RN given refers to non-specified isomer		1.9610
4-aminostilbene
4-aminostilbene: RN given refers to cpd without isomeric designation		1.9610
nefurthiazole
nefurthiazole: structure		1.9610C-nitro compound;
furans
vitamin k semiquinone radical
vitamin K semiquinone radical: found in active preparations of vitamin K-dependent carboxylase. vitamin K : Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.		1.9810
4,4'-diaminostilbene
[no description available]		1.9610
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.3720cysteiniumfundamental metabolite
deoxyguanosine
[no description available]		2.6930purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
phosphorus radioisotopes
Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.		2.3820
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Bladder Cancer
[description not available]		03.1250
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		03.1250
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.4820
Acute Liver Injury, Drug-Induced
[description not available]		01.9610
Experimental Hepatoma
[description not available]		02.3720
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		01.9610
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9610
Cancer of Liver
[description not available]		01.9610
Experimental Neoplasms
[description not available]		02.3620
Experimental Mammary Neoplasms
[description not available]		01.9610
Liver Neoplasms
Tumors or cancer of the LIVER.		01.9610
Carcinoma, Transitional Cell
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.		0210
Benign Neoplasms
[description not available]		01.9510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		01.9510
Carcinoma, Epidermoid
[description not available]		01.9810
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		01.9810
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		01.9810
Chromosome-Defective Micronuclei
[description not available]		01.9710