Page last updated: 2024-12-06

n-hydroxy-4-acetylaminobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-hydroxy-4-acetylaminobiphenyl: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N-hydroxy-4-acetylaminobiphenyl : A hydroxamic acid that is biphenyl-4-amine bearing N-hydroxy and N-acetyl substituents. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID20527
CHEMBL ID279548
CHEBI ID16434
SCHEMBL ID3345880
MeSH IDM0041512

Synonyms (30)

Synonym
n-hydroxy-4-acetamidodiphenyl
n-hydroxy-n-4-biphenylacetamide
n-([1,1'-biphenyl]-4-yl)-n-hydroxyacetamide
n-(4-biphenylyl)acetohydroxamic acid
n-4-biphenylylacetohydroxamic acid
n-acetyl-4-biphenylhydroxylamine
n-hydroxy-4-acetamidobiphenyl
CHEBI:16434 ,
acetamide, n-(1,1'-biphenyl)-4-yl-n-hydroxy-
n-4-(n-hydroxyacetamido)biphenyl
acetohydroxamic acid, n-4-biphenylyl-
4-biphenylacethydroxamic acid
ccris 1061
n-(1,1'-biphenyl)-4-yl-n-hydroxyacetamide
brn 2807692
n-acetyl-n-hydroxy-4-aminobiphenyl
n-hydroxy-4-(acetylamino)biphenyl
n-hydroxy-4-acetylaminobiphenyl
C04081
4463-22-3
n-hydroxy-n-4-acetylaminobiphenyl
n-hydroxy-n-(4-phenylphenyl)-acetamide
CHEMBL279548
SCHEMBL3345880
n-[1,1'-biphenyl]-4-yl-n-hydroxyacetamide #
UNHSJQXRZCIATF-UHFFFAOYSA-N
4-acetamido-n-hydroxybiphenyl
acetamide, n-[1,1'-biphenyl]-4-yl-n-hydroxy-
DTXSID7020718
Q27101903

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" BPDE was about 1000-fold more toxic and mutagenic than N-OH-AABP in TK6 cells on a molar basis."( Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity.
Fan, W; Jing, L; Luo, W; Ricicki, E; Vouros, P; Xie, H; Zarbl, H; Zhao, LP, 2005
)
0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxamic acidA compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID39229Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with partially purified hepatic enzyme in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID143757Inhibition of AHAT-catalyzed transacylation of 4-aminoazobenzene1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
N-arylhydroxamic acid N,O-acyltransferase. Positional requirements for the substrate hydroxyl group.
AID85005Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using N-ethyl maleimide as inhibitor (1.0 mM) in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID39227Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with hamster hepatic enzyme after dialysis1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID168097Carcinogenic activity on mixed data after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID167927Carcinogenic activity on all sites after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID84141Effect for methylthio adduct formation in presence of 0.1 mM N-hydroxy-4-aminobiphenyl and 10 mM N-acetylmethioninein hamster hepatic AHAT preparation at 30 min1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID227347Compound inhibit the AHAT-catalyzed transacetylation activity; Active1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID227171AHAT-catalyzed transacetylation rate at 0.5-1.0 concentration1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID39230Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with partially purified hepatic enzyme in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID167939Carcinogenic activity on breast after oral administration of the compound1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID167955Carcinogenic activity on ear duct after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID168110Carcinogenic activity on other sites after oral administration1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID171629Transacetylation rate in rat hepatic AHAT preparation1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID85004Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using 4-chloro mercuri benzenesulfonate as inhibitor (1.0 mM) in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID183000Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using iodo acetamide as inhibitor (1.0 mM) in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID39228Tested for its arylhydroxamic acid N,O-Acyltransferase (AHAT) catalyzed transacetylation of aminoazobenzene with hamster hepatic enzyme before dialysis1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID85006Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using iodo acetamide as inhibitor (1.0 mM) in hamster1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID182999Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using N-ethyl maleimide as inhibitor (1.0 mM) in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
AID168085Carcinogenic activity on liver after oral administration of the compound1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID84162Transacetylation rate in hamster hepatic AHAT preparation1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.
AID182998Aminoazobenzene transacetylation inhibition by partially purified hepatic enzyme using 4-chloro mercuri benzenesulfonate as inhibitor (1.0 mM) in rat1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (29)

TimeframeStudies, This Drug (%)All Drugs %
pre-199013 (44.83)18.7374
1990's9 (31.03)18.2507
2000's5 (17.24)29.6817
2010's2 (6.90)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.78 (24.57)
Research Supply Index3.40 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]