| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
gossypol
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer. | 3.08 | 1 | 0 | | |
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite. | 3.15 | 1 | 0 | catechin | antioxidant;
plant metabolite |
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46. | 2.1 | 1 | 0 | metal allergen;
nickel group element atom;
platinum group metal atom | |
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. | 3.15 | 1 | 0 | flavans;
gallate ester;
polyphenol | antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite |
triptonide
triptonide: extracted from Tripterygium wilfordii; structure given in first source. triptonide : A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. | 7.55 | 2 | 0 | butenolide;
cyclic ketone;
diterpene triepoxide;
organic heteroheptacyclic compound | anti-inflammatory agent;
antineoplastic agent;
immunosuppressive agent |
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. | 3.15 | 1 | 0 | organic peroxide;
sesquiterpene lactone | antimalarial;
plant metabolite |
nagilactone c
nagilactone C: norditerpene lactone isolated from leaves of Podocarpus; structure | 2.25 | 1 | 0 | | |
brusatol
brusatol: quassinoid from B. javanica; structure | 2.25 | 1 | 0 | triterpenoid | |
triptolide
[no description available] | 5.82 | 11 | 0 | diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound | antispermatogenic agent;
plant metabolite |
parthenolide
[no description available] | 2.25 | 1 | 0 | germacranolide | |
obacunone
obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane | 2.25 | 1 | 0 | limonoid | |
celastrol
[no description available] | 2.05 | 1 | 0 | monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite |
chlorolissoclimide
chlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson | 2.25 | 1 | 0 | | |
tripchlorolide
tripchlorolide: a chloro-tri-epoxide analog of triptolide; from woody part of the root of Tripterygium wilfordii Hook; structure given in first source | 1.98 | 1 | 0 | | |
bruceine a
bruceine A: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to (11 beta,12 alpha,15 beta)-isomer; structure given in first source | 2.25 | 1 | 0 | quassinoid | |
bruceine b
bruceine B: quassinoid which inhibits protein synthesis & DNA synthesis in cells; structure in first source | 2.25 | 1 | 0 | triterpenoid | |
jolkinolide a
jolkinolide A: isolated from Euphorbia fischeriana | 2.25 | 1 | 0 | diterpene lactone | metabolite |
jolkinolide b
jolkinolide B: isolated from Euphorbia fischeriana | 2.25 | 1 | 0 | diterpene lactone | metabolite |
limonin
[no description available] | 2.25 | 1 | 0 | epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound | inhibitor;
metabolite;
volatile oil component |
thapsigargin
Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. | 2.25 | 1 | 0 | butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone | calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor |
bruceantin
[no description available] | 2.25 | 1 | 0 | triterpenoid | |
andrographolide
[no description available] | 2.25 | 1 | 0 | carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol | anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite |
shihulimonin a
shihulimonin A: isolated from Evodia rutaecarpa; structure in first source | 2.25 | 1 | 0 | limonoid | |
indium
Indium: A metallic element, atomic number 49, atomic weight 114.818, symbol In. It is named from its blue line in the spectrum.. indium atom : A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum. | 2.1 | 1 | 0 | boron group element atom | |
dichapetalin a
dichapetalin A: isolated from Dichapetalum; structure in first source | 2.25 | 1 | 0 | | |
ginkgolide b
[no description available] | 2.25 | 1 | 0 | | |
17-hydroxyjolkinolide b
17-hydroxyjolkinolide B: isolated from Euphorbia fischeriana | 2.25 | 1 | 0 | diterpene lactone | metabolite |
bn 52020
[no description available] | 2.25 | 1 | 0 | | |
dichlorolissoclimide
dichlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson | 2.25 | 1 | 0 | | |
14-o-phosphonooxymethyltriptolide
14-O-phosphonooxymethyltriptolide disodium salt: pro-drug of triptolide; has antineoplastic activity | 2.25 | 1 | 0 | | |
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof. | 5.72 | 10 | 0 | | |