Compounds > thiosemicarbazone h
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thiosemicarbazone h

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Description

thiosemicarbazone H: antibacterial & antiparasitic properties; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5494319
CHEMBL ID279779
MeSH IDM0108813

Synonyms (23)

Synonym
haphmtsc
n-[(e)-1-(2-pyridyl)ethylideneamino]azepane-1-carbothioamide
1h-azepine-1-carbothioic acid, hexahydro-, [1-(2-pyridinyl)ethylidene]hydrazide
2-acetylpyridine hexamethyleneimine-thiosemicarbazone
nsc318807
1h-azepine-1-carbothioic acid, [1-(2- pyridinyl)ethylidene]hydrazide
71555-41-4
nsc-318807
thiosemicarbazone h
azacycloheptane-1-thiocarboxylic acid, 2-(1-(2-pyridyl)ethylidene)hydrazide
hexahydro-1h-azepine-1-thiocarboxylic acid (1-(2-pyridyl)ethylidene)hydrazide
nsc 318807
brn 1478118
1h-azepine-1-carbothioic acid, hexahydro-, (1-(2-pyridinyl)ethylidene)hydrazide
1h-azepine-1-thiocarboxylic acid, hexahydro-(1-(2-pyridyl)ethylidene)hydrazide
2-acetylpyridinehexamethyleneimine-thiosemicarbazone
CHEMBL279779
BRD-K71462943-001-01-9
azacycloheptane-1-thiocarboxylic acid 2-(1-(2-pyridyl)ethylidene) hydrazide
CCG-102451
1h-azepine-1-carbothioic acid, hexahydro-, [1-(2-pyridinyl)ethylidene]hydrazide, (e)-
DTXSID801128013
172615-53-1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (118)

Assay IDTitleYearJournalArticle
AID146995Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 3 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147463Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 96 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146834Colorimetric quantification of male Onchocerca gutturosa viability, expressed as % inhibition of formazan formation at 5*10e-5 M conc. by using tetrazolium Dye MTT assay1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147274Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 1 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147307Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 2 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147450Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 1 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147277Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 2 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147151Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 72 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147287Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 0.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147301Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 96 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147134Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 3.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147453Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 168 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID159438Increased mean survival time in drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 80 mg/kg; cures 4 of 51983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl)ethyl]-3-thiosemicarbazides as potential antimalarial agents.
AID147441Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 3.5 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147294Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 24 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147278Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 2.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147138Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 72 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147303Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 1 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147116Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 48 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147439Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 3 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147290Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 168 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147292Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 2 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147143Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 2 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147122Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-8 M at 1 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147145Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 24 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID478787Selectivity index, ratio of IC50 for mouse J774 cells to MIC for Mycobacterium tuberculosis H37Rv2010European journal of medicinal chemistry, May, Volume: 45, Issue:5
Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.
AID147118Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 96 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147137Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 48 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147299Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 48 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID159280Increased mean survival time in drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 160 mg/kg; cured 3 of 51983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl)ethyl]-3-thiosemicarbazides as potential antimalarial agents.
AID9445anti-filarial Activity was measured against Acanthocheilonema viteae in jirds at 25 mg/kg/day(5 days) dose1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID478786Cytotoxicity against mouse J774 cells after 24 hrs by resazurin assay2010European journal of medicinal chemistry, May, Volume: 45, Issue:5
Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.
AID147141Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 1 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147275Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 1.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147460Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 4.5 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147273Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 168 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147451Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 1.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146996Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 3.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147279Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 24 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147276Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 168 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147448Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 96 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146993Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 2.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID38488anti-filarial Activity was measured against Brugia pahangi in jirds at 100 mg/kg/day(5 days) dose1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID38490anti-filarial Activity was measured against Brugia pahangi in jirds at 12.5 mg/kg/day(5 days) dose1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147445Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 4.5 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147132Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 24 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147281Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 3.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147133Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 3 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147454Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 2 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147461Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 48 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146989Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 1 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147449Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 0.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147115Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 4.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147117Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 72 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147293Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 2.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147304Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 1.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147125Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-8 M at 2.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147443Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 4 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147280Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 3 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147288Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 1 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147121Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-8 M at 0.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147455Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 2.5 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147456Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 24 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID478785Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by resazurine microtiter assay2010European journal of medicinal chemistry, May, Volume: 45, Issue:5
Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.
AID147144Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 2.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147139Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 96 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147120Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 4 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147149Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 4.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147310Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 24 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146990Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 1.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147284Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 48 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147148Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 4 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147457Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 3 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146830Colorimetric quantification of male Onchocerca gutturosa viability, expressed as % inhibition of formazan formation at 1.95*10e-7 M conc. by using tetrazolium Dye MTT assay1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147123Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-8 M at 1.05 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147136Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 4.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147458Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 3.5 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147306Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 168 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147289Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 1.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147298Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 4.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147124Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-8 M at 2 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147140Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 0.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147135Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 4 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147464Colorimetric quantification of male Onchocerca volvulus viability, expressed as % inhibition of formazan formation at 3.1*10e-6 M conc. by using tetrazolium Dye MTT assay1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147152Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 96 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147146Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 3 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID159307Increased mean survival time in drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 640 mg/kg; cured 2 of 51983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl)ethyl]-3-thiosemicarbazides as potential antimalarial agents.
AID147309Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 2.5 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147285Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 72 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147282Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 4 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147459Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 4 h;ND=not done1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147462Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 5*10e-5 M at 72 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146832Colorimetric quantification of male Onchocerca gutturosa viability, expressed as % inhibition of formazan formation at 3.1*10e-6 M conc. by using tetrazolium Dye MTT assay1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147119Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 0.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146831Colorimetric quantification of male Onchocerca gutturosa viability, expressed as % inhibition of formazan formation at 3.05*10e-9 M conc. by using tetrazolium Dye MTT assay1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID159294Increased mean survival time in drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 320 mg/kg; cured 2 of 51983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl)ethyl]-3-thiosemicarbazides as potential antimalarial agents.
AID146988Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 0.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146992Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 2 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147297Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 4 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146994Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 24 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146991Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 1.95*10e-8 M at 168 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID159299Increased mean survival time in drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 40 mg/kg dose1983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl)ethyl]-3-thiosemicarbazides as potential antimalarial agents.
AID147302Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 0.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147150Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 48 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID38492anti-filarial Activity was measured against Brugia pahangi in jirds at 25 mg/kg/day(5 days) dose1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147466Colorimetric quantification of male Onchocerca volvulus viability, expressed as % inhibition of formazan formation at 5*10e-6 M conc. by using tetrazolium Dye MTT assay1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147447Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 72 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147283Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 4.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147300Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 72 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147142Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 1.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147286Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 4.88*10e-8M at 96 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147296Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 3.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147147Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 3.5 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147129Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 3.05*10e-9 M at 168 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147446Mean motility score for treated Onchocerca volvulus excluding LLCMK2 feeder cells at a concentration of 3.1*10e-6 M at 48 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID147295Mean motility score for treated Onchocerca gutturosa involving LLCMK2 feeder cells at a concentration of 5*10e-5 M at 3 h1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID146833Colorimetric quantification of male Onchocerca gutturosa viability, expressed as % inhibition of formazan formation at 4.88*10e-8M conc. by using tetrazolium Dye MTT assay1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
AID9443anti-filarial Activity was measured against Acanthocheilonema viteae in jirds at 12.5 mg/kg/day(5 days) dose1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
2-acetylpyridine thiosemicarbazones. 13. Derivatives with antifilarial activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (37.50)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.54 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0310alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		1.9610pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		1.9610amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.0510copper group element atom;
elemental gold
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		2.0310
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		1.9610adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
2-acetylpyridine thiosemicarbazone
2-acetylpyridine thiosemicarbazone: RN given refers to parent cpd		2.4120
2-acetylpyridine-4-methyl-3-thiosemicarbazone
[no description available]		2.0510
2-acetylpyridine semicarbazone
[no description available]		2.0510
di-2-pyridyl ketone isonicotinoyl hydrazone
di-2-pyridyl ketone isonicotinoyl hydrazone: a chelating agent; structure in first source		2.0510
alpha-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol
alpha-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol: structure		1.9610
mefloquine
Mefloquine: A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.. mefloquine : A racemate composed of (+)-(11R,2'S)- and (-)-(11S,2'R)-enantiomers of mefloquine. An antimalarial agent which acts as a blood schizonticide; its mechanism of action is unknown.		1.9610
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Elaeophoriasis
[description not available]		01.9710
Filariasis
Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.		01.9710
Infections, Plasmodium
[description not available]		01.9610
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		01.9610