Black Water Fever

A complication of MALARIA, FALCIPARUM characterized by the passage of dark red to black urine.

Synonym
Malaria, Hemolytic
Black Water Fever
Blackwater Fever

Excerpt	Reference
"Blackwater fever is characterized by severe intravascular hemolysis with renal failure caused by recurrent use of quinine for prophylaxis."	( Brah Bouzou, S; Djibo, A; Souna-Adamou, A, 2000)
"Blackwater fever is a rare manifestation of falciparum malaria characterized by sudden intravascular hemolysis followed by fever and hemoglobinuria."	( Goyal, RK; Khandelwal, V; Kumhar, MR; Udawat, H, 2001)
"Blackwater fever is a clinical entity characterized by acute intravascular hemolysis classically occuring after the re-introduction of quinine in long-term residents in Plasmodium falciparum endemic areas and repeatedly using the product."	( Bedos, JP; Bruneel, F; Danis, M; Gachot, B; Regnier, B; Vachon, F; Wolff, M, 2002)
"Blackwater fever is characterized by acute intravascular hemolysis with hemoglobinuria in patients with Plasmodium falciparum malaria."	( Audagnotto, S; Corachan, M; Di Perri, G; Gobbi, F; Nkurunziza, I; Trentini, L, 2005)
"Blackwater fever is a rare but serious form of malaria in children."	( Diakite, M; Keita, MM; Konate, S; Oumar, AA; Poudiougou, B; Sall, A; Sylla, M; Togo, B, 2007)
"Blackwater fever is a severe affection whose diagnosis should be evoked using the color of urine."	( Diakite, M; Keita, MM; Konate, S; Oumar, AA; Poudiougou, B; Sall, A; Sylla, M; Togo, B, 2007)
"Blackwater fever is a massive hemolytic event usually occurring in the context of repeated falciparum malaria infections and intermittent quinine use."	( Shanks, GD, 2017)
"Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine."	( Chavatte, JM; Ho, J; Huggan, PJ; Lin, RTPV; Ng, CH, 2018)
"Blackwater fever is a haemolytic syndrome associated with malaria that coincided with the use of quinine chemoprophylaxis."	( Shanks, GD, 2022)

Excerpt	Reference
"Five cases of blackwater fever (BWF) are described, all of whom had a history of recent quinine therapy."	( Clerinx, J; Colebunders, R; Coppens, G; Depraetere, K; Peetermans, WE; Schroyens, W; Van den Ende, J; Van den Enden, E; Van Gompel, A; Van Haegenborgh, T; Verstraeten, T, 1998)
"We present a case of blackwater fever, having occurred after administration of quinine, which was treated successfully with artemether."	( Goyal, RK; Khandelwal, V; Kumhar, MR; Udawat, H, 2001)
"This report describes a case of classic blackwater fever in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether-lumefantrine combination therapy."	( Chavatte, JM; Ho, J; Huggan, PJ; Lin, RTPV; Ng, CH, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	23 (42.59)	23.3326
1990's	7 (12.96)	12.5806
2000's	8 (14.81)	18.1394
2010's	14 (25.93)	28.8240
2020's	2 (3.70)	9.53

Drug	Relationship Strength	Studies
quinacrine	low	2
lactic acid	low	1
urea	low	1
aspirin	low	1
chloroquine	low	7
ddt	low	1
primaquine	low	1
pyrimethamine	low	5
sulfamonomethoxine	low	1
sulfanilamide	low	1
prednisolone	low	1
prednisone	low	2
lysine	low	1
sulfadoxine	low	3
halofantrine	low	4
fanasil, pyrimethamine drug combination	low	1
artemisinin	low	1
artemether	low	5
atovaquone	low	1
acetylsalicylic acid lysinate	low	1
artesunic acid	low	2
piperaquine	low	1
cortisone	low	3
sesquiterpenes	low	3
quinine	low	25
naphthoquinones	low	1
bilirubin	low	1
proguanil	low	4
lumefantrine	low	1
cgp-56697	low	2
beta-escin	low	1
artenimol	low	1
mefloquine	low	3
piperidines	low	1
phenanthrenes	low	4

Protein Targets (418)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
TDP1 protein	13	0	0	13
AR protein	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
pregnane X nuclear receptor	10	0	0	10
estrogen nuclear receptor alpha	16	0	0	16
G	4	0	0	4
thyroid hormone receptor beta isoform 2	11	0	0	11
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	8
Bile salt export pump	0	12	0	12
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Inositol hexakisphosphate kinase 1	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	8	0	8
cytochrome P450 2C9, partial	4	0	0	4
Chain A, Ferritin light chain	1	0	0	1
RAR-related orphan receptor gamma	10	0	0	10
USP1 protein, partial	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
nonstructural protein 1	1	0	0	1
estrogen-related nuclear receptor alpha	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
Histone H2A.x	5	0	0	5
chromobox protein homolog 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
geminin	8	0	0	8
Cellular tumor antigen p53	8	0	0	8
TAR DNA-binding protein 43	3	0	0	3
Dihydroorotate dehydrogenase	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	5	0	0	5
Cytochrome P450 3A4	0	3	0	3
Cytochrome P450 2B6	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
thioredoxin reductase	4	0	0	4
GLS protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
thyroid stimulating hormone receptor	4	0	0	4
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	5	0	0	5
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
cytochrome P450 2D6	7	0	0	7
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	6	0	0	6
Rac1 protein	0	0	1	1
IDH1	4	0	0	4
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
Bloom syndrome protein isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	5	1	8
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	3	1	0	4
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	1	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
phosphopantetheinyl transferase	4	0	0	4
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
GLI family zinc finger 3	10	0	0	10
Microtubule-associated protein tau	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
retinoid X nuclear receptor alpha	7	0	0	7
peroxisome proliferator activated receptor gamma	5	0	0	5
aryl hydrocarbon receptor	6	0	0	6
activating transcription factor 6	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Dihydroorotate dehydrogenase	0	1	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C9 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
transcriptional regulator ERG isoform 3	1	0	0	1
heat shock protein beta-1	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Vpr	1	0	0	1
peripheral myelin protein 22	5	0	0	5
histone acetyltransferase KAT2A isoform 1	2	0	0	2
lamin isoform A-delta10	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Cytochrome b	0	1	0	1
Glutamate receptor 2	6	0	0	6
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Histamine H2 receptor	1	0	0	1
Spike glycoprotein	6	1	1	8
Guanine nucleotide-binding protein G	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	2
Dihydroorotate dehydrogenase	0	2	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, Cruzipain	2	0	0	2
vitamin D3 receptor isoform VDRA	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
PPM1D protein	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	3	0	0	3
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Amyloid-beta precursor protein	0	1	0	2
Histidine-rich protein PFHRP-II	0	3	0	4
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Muscarinic acetylcholine receptor M1	0	3	0	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	3	0	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
endonuclease IV	2	0	0	2
acetylcholinesterase	3	0	0	3
GALC protein	2	0	0	2
progesterone receptor	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
dopamine D1 receptor	2	0	0	2
pregnane X receptor	4	0	0	4
regulator of G-protein signaling 4	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
peripheral myelin protein 22 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Glucocorticoid receptor	0	6	2	13
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Glycine receptor subunit alpha-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
GABA theta subunit	2	0	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
farnesoid X nuclear receptor	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
Caspase-7	2	0	0	2
thyroid hormone receptor beta isoform a	1	0	0	1
caspase-3	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Androgen receptor	0	2	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
Carbonic anhydrase 12	0	2	0	3
Bile salt export pump	0	1	0	1
Albumin	0	1	1	2
Carbonic anhydrase 3	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	3	0	4
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	0	5
Carbonic anhydrase 7	0	2	0	3
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 9	0	3	0	4
Carbonic anhydrase 13	0	2	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
Fumarate hydratase	4	0	0	4
polyprotein	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
Cationic amino acid transporter 3	0	1	0	1
luciferase	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	2	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
Trace amine-associated receptor 5	0	0	2	2
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
glp-1 receptor, partial	1	0	0	1
Smad3	1	0	0	1
67.9K protein	2	0	0	2
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
streptokinase A precursor	0	0	1	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Dihydrofolate reductase	0	2	0	2
Estrogen receptor	0	0	1	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Dihydrofolate reductase	0	2	1	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Estrogen receptor beta	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
N	0	1	0	1
ATAD5 protein, partial	1	0	0	1
NPYLR7B	0	0	1	1
arylsulfatase A	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Major prion protein	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	1	4
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Trypanothione reductase	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Aldehyde oxidase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
cytochrome P450 2C19 precursor	1	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Cholinesterase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Protein argonaute-2	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (54)

Protein Targets (418)

Black Water Fever

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (54)

Drugs Studied (38)

Protein Targets (418)