At-V1

A chromosome instability syndrome resulting from a defective response to DNA double-strand breaks. In addition to characteristic FACIES and MICROCEPHALY, patients have a range of findings including RADIOSENSITIVITY, immunodeficiency, increased cancer risk, and growth retardation. Causative mutations occur in the NBS1 gene, located on human chromosome 8q21. NBS1 codes for nibrin, the key regulator protein of the R/M/N (RAD50/MRE11/NBS1) protein complex which senses and mediates cellular response to DNA DAMAGE caused by IONIZING RADIATION.

Synonym
Microcephaly with Normal Intelligence, Immunodeficiency, and Lymphoreticular Malignancies
Nonsyndromal Microcephaly, Autosomal Recessive, with Normal Intelligence
Berlin Breakage Syndrome
At-V1
Seemanova Syndrome 2
Ataxia-Telangiectasia Variant V1
Nijmegen Breakage Syndrome
Ataxia-Telangiectasia Variant 1
Immunodeficiency, Microcephaly, And Chromosomal Instability
Seemanova Syndrome II

Excerpt	Reference
"Nijmegen breakage syndrome is characterized by microcephaly, growth retardation, abnormal facial appearance, spontaneous chromosomal rearrangements, immunodeficiency, and a high predisposition to cancer development, predominantly lymphoma."	( Begovic, D; Dumic, M; Krnic, N; Kusec, R; Labar, B; Nola, M; Radman, I; Rados, M, 2007)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	14 (53.85)	18.1394
2010's	11 (42.31)	28.8240
2020's	1 (3.85)	9.53

Drug	Relationship Strength	Studies
hydroxyurea	low	1
ag 1879	low	1
procarbazine	low	1
temozolomide	low	1
thymidine	low	1
prednisone	low	2
bromodeoxyuridine	low	1
tyrosine	low	1
tryptophan	low	1
arginine	low	1
thiazoles	low	1
diepoxybutane	low	1
trolamine salicylate	low	1
thiazolyl blue	low	1
o-(6)-methylguanine	low	1
sb 203580	low	1
dactinomycin	low	2
ku 55933	low	1
pulmicort	low	1
sirolimus	low	1
tanespimycin	low	1
nad	low	1
guanine	low	1
dacarbazine	low	1
methylnitronitrosoguanidine	low	1
phenanthrenes	low	2

Protein Targets (844)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Lck Kinase	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	0	1
Chain A, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Tyrosine-protein kinase Lyn	0	1	0	1
glp-1 receptor, partial	2	0	0	2
Skn7p	0	0	0	1
TDP1 protein	8	0	0	8
Smad3	2	0	0	2
regulator of G-protein signaling 4	3	0	0	3
nonstructural protein 1	1	0	0	1
67.9K protein	2	0	0	2
LAP4	0	0	1	1
RPL19A	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
amino acid transporter AGP1	0	0	1	1
geminin	7	0	0	7
survival motor neuron protein isoform d	6	0	0	6
Receptor-interacting serine/threonine-protein kinase 2	0	2	2	4
Tyrosine-protein kinase JAK2	0	1	2	3
Tyrosine-protein kinase ABL1	0	3	2	5
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Epidermal growth factor receptor	0	3	2	5
Tyrosine-protein kinase Lck	0	3	2	5
Proto-oncogene tyrosine-protein kinase LCK	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	2	3
Tyrosine-protein kinase Lyn	0	1	2	3
Tyrosine-protein kinase HCK	0	1	2	3
Proto-oncogene tyrosine-protein kinase Src	0	3	2	5
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-B receptor 2	0	2	3	5
Alpha-synuclein	2	0	0	2
Tyrosine-protein kinase CSK	0	1	2	3
Tyrosine-protein kinase ZAP-70	0	1	1	2
Casein kinase I isoform delta	0	2	2	4
TAR DNA-binding protein 43	2	0	0	2
Mitogen-activated protein kinase 14	0	3	3	6
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	3	0	0	3
phosphopantetheinyl transferase	2	0	0	2
NFKB1 protein, partial	3	0	0	3
GLS protein	5	0	0	5
thyroid stimulating hormone receptor	5	0	0	5
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	3	0	0	3
flap endonuclease 1	2	0	0	2
DNA polymerase iota isoform a (long)	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	2	0	0	2
Cytochrome P450 3A4	0	2	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
interleukin 8	4	0	0	4
pregnane X receptor	2	0	0	2
RAR-related orphan receptor gamma	6	0	0	6
ATAD5 protein, partial	1	0	0	1
Microtubule-associated protein tau	4	0	0	4
AR protein	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	4	0	0	4
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	4	0	0	4
estrogen-related nuclear receptor alpha	9	0	0	9
pregnane X nuclear receptor	8	0	0	8
estrogen nuclear receptor alpha	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
arylsulfatase A	2	0	0	2
IDH1	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
Nuclear hormone receptor family member daf-12	0	0	1	1
thyroid hormone receptor beta isoform 2	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
peripheral myelin protein 22	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Thymidine kinase, cytosolic	0	3	0	5
Glutamate receptor 2	3	0	0	3
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Nuclear receptor ROR-gamma	4	0	0	4
Spike glycoprotein	2	0	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
cytochrome P450 2D6	3	0	0	3
peroxisome proliferator activated receptor gamma	5	0	0	5
thyroid stimulating hormone receptor	3	0	0	3
activating transcription factor 6	4	0	0	4
lamin isoform A-delta10	5	0	0	5
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Bile salt export pump	0	5	0	5
Matrix metalloproteinase-9	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
Isocitrate lyase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	4	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Cruzipain	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
USP1 protein, partial	5	0	0	5
GLI family zinc finger 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
estrogen receptor 2 (ER beta)	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
farnesoid X nuclear receptor	2	0	0	2
peroxisome proliferator-activated receptor delta	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
caspase-3	1	0	0	1
RAD51	0	1	0	1
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	3	0	0	3
Caspase-7	1	0	0	1
Bloom syndrome protein isoform 1	3	0	0	3
vitamin D3 receptor isoform VDRA	5	0	0	5
thyroid hormone receptor beta isoform a	2	0	0	2
caspase-3	1	0	0	1
huntingtin isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	4	0	1	5
Interferon beta	4	0	0	4
Cellular tumor antigen p53	6	0	0	6
ATP-dependent translocase ABCB1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit delta	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	1	5
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	1	5
Growth factor receptor-bound protein 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-2	4	0	1	5
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	2	3
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
GABA theta subunit	4	0	1	5
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	4	0	1	5
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
acetylcholinesterase	2	0	0	2
Fumarate hydratase	3	0	0	3
EWS/FLI fusion protein	4	0	0	4
polyprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Carbonic anhydrase 2	0	2	0	5
Stromelysin-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Carbonic anhydrase 4	0	1	0	3
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Carbonic anhydrase 9	0	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	1	2
Serine/threonine-protein kinase mTOR	0	2	2	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Serine-protein kinase ATM	0	2	0	2
Serine/threonine-protein kinase ATR	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Methylated-DNA--protein-cysteine methyltransferase	0	1	0	2
Cyclin-dependent kinase 2	0	1	2	3
Xanthine dehydrogenase/oxidase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
thioredoxin glutathione reductase	2	0	0	2
Glucocorticoid receptor	0	4	2	6
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Chain A, Beta-lactamase	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
Thrombopoietin	1	0	0	1
G	2	0	0	2
glucocerebrosidase	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Estrogen receptor	0	1	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Progesterone receptor	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Mineralocorticoid receptor	0	1	1	2
Androgen receptor	0	2	0	2
Interleukin-5 receptor subunit alpha	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
Estrogen receptor beta	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Erk2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
PPM1D protein	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Bone morphogenetic protein receptor type-1B	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	2	2
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Citron Rho-interacting kinase	0	1	2	3
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	2	2
Cyclin-G-associated kinase	0	1	2	3
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	2	2
Mitogen-activated protein kinase 13	0	1	2	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 2	0	1	0	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	2	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	1	2	3
Cyclin-dependent kinase 14	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	1	2
Receptor tyrosine-protein kinase erbB-2	0	2	1	3
High affinity nerve growth factor receptor	0	0	2	2
Protein kinase C gamma type	0	1	0	1
Myeloperoxidase	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Protein kinase C beta type	0	1	1	2
Insulin receptor	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Tyrosine-protein kinase Yes	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	2	2
Insulin-like growth factor 1 receptor	0	0	2	2
Neutrophil elastase	0	1	0	1
Hepatocyte growth factor receptor	0	0	2	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Platelet-derived growth factor receptor beta	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	2	2
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Cytochrome P450 2D6	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Serine/threonine-protein kinase pim-1	0	0	2	2
Tyrosinase	0	1	0	1
Fibroblast growth factor receptor 1	0	0	2	2
Cholesteryl ester transfer protein	0	1	1	2
Cytochrome P450 2C9	0	2	0	2
Myosin light chain kinase, smooth muscle	0	0	1	1
Cyclin-dependent kinase 4	0	0	2	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	2	3
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	1	1	2
cAMP-dependent protein kinase catalytic subunit alpha	0	1	2	3
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Casein kinase II subunit alpha'	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	2	2
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	2	3
Prostaglandin G/H synthase 1	0	1	0	1
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	1	2
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	2	2
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Mitogen-activated protein kinase 1	0	0	2	2
Adenosine receptor A2a	0	2	0	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
Wee1-like protein kinase	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	0	1	1
Adenosine receptor A1	0	2	0	2
Mitogen-activated protein kinase 4	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	2	2
RAC-beta serine/threonine-protein kinase	0	0	2	2
G protein-coupled receptor kinase 4	0	0	1	1
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Dual specificity protein kinase TTK	0	0	2	2
Prostaglandin G/H synthase 2	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	2	3
Receptor-type tyrosine-protein kinase FLT3	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	1	2	3
Serine/threonine-protein kinase receptor R3	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Protein kinase C iota type	0	1	2	3
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	1	2	3
Tyrosine-protein kinase FRK	0	0	2	2
Tyrosine-protein kinase SYK	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	1	2	3
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Histamine H2 receptor	1	0	0	1
Mitogen-activated protein kinase 14	0	1	1	2
Casein kinase I isoform alpha	0	0	2	2
MAP kinase-activated protein kinase 2	0	0	2	2
Cyclin-dependent kinase 8	0	0	1	1
Casein kinase I isoform epsilon	0	1	2	3
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	2	2
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 12	0	1	2	3
Mitogen-activated protein kinase 10	0	2	2	4
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	2	2
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
Protein kinase C epsilon type	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 1	0	1	2	3
Angiopoietin-1 receptor	0	1	1	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Protein kinase C theta type	0	1	2	3
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	2	3
Tyrosine-protein kinase BTK	0	0	2	2
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	1	1	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	2	2
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	1	1
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Serine/threonine-protein kinase D1	0	1	1	2
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	0	2	2
Mitogen-activated protein kinase 11	0	1	3	4
Serine/threonine-protein kinase STK11	0	0	2	2
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
AP2-associated protein kinase 1	0	0	2	2
Myosin light chain kinase 3	0	0	2	2
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
P2X purinoceptor 7	0	1	0	1
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	2	2
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	2	2
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Aurora kinase B	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Serine/threonine-protein kinase Nek1	0	0	2	2
Cyclin-dependent kinase 15	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
SRSF protein kinase 1	0	0	1	1
P2X purinoceptor 7	0	1	0	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase D2	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
Dual specificity protein kinase CLK4	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	2	2
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	1	1	2
BMP-2-inducible protein kinase	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase NLK	0	1	2	3
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	2	2
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	1	2	3
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	2	2
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	2	2
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
ADP/ATP translocase 2	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	1	1	2
DNA topoisomerase 2-alpha	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Deoxycytidine kinase	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
ATP-dependent RNA helicase DDX1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Septin-9	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Corticotropin releasing hormone receptor 2	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Lysine-specific demethylase 6B	0	1	0	1
Histone deacetylase 3	0	1	0	1
Lysine-specific demethylase 4B	0	1	0	1
ATP-dependent molecular chaperone HSP82	0	1	0	1
Heat shock protein HSP 90-alpha	0	3	2	5
Heat shock protein HSP 90-beta	0	2	2	6
ATP-dependent molecular chaperone HSC82	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Endoplasmin	0	1	1	2
Histone deacetylase 4	0	1	0	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
Histone deacetylase 1	0	1	0	1
Heat-shock protein	0	1	0	1
Putative heat shock protein HSP 90-alpha A4	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Lysine-specific demethylase 4C	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Carbonic anhydrase 12	0	1	0	3
Carbonic anhydrase 1	0	1	0	3
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
M-phase phosphoprotein 8	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase 6	0	0	0	2
Substance-P receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 7	0	0	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 15	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Research

Studies (26)

Protein Targets (844)

At-V1

Synonyms(10)

Research Excerpts

Overview

Research

Studies (26)

Drugs Studied (34)

Protein Targets (844)