Page last updated: 2024-10-15

nk314

Description

NK314: a benzo[c]phenanthridine that inhibits topoisomerase IIalpha and G2 cell cycle arrest; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	156596431
MeSH ID	M0512543

Synonyms (8)

Synonym
nk314
208237-49-4
1h-(1,3)benzodioxolo(5,6-c)pyrrolo(1,2-f)phenanthridinium, 2,3-dihydro-4-hydroxy-5-methoxy-, chloride (1:1)
1-hydroxy-2-methoxy-11a,13,14,15-tetrahydro-6ah-(1,3)dioxolo(4',5':4,5)benzo(1,2-c)pyrrolo(1,2-f)phenanthridin-12-ium chloride
nk-314
bh68fxm7x8 ,
1h-(1,3)benzodioxolo(5,6-c)pyrrolo(1,2-f)phenanthridinium, 2,3-dihydro-4-hydroxy-5-methoxy-, chloride
unii-bh68fxm7x8

Research Excerpts

Overview

NK314 is a novel synthetic benzo[c]phenanthridine alkaloid. It has recently entered clinical trials as an antitumor compound.

Excerpt	Reference
"NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that has recently entered clinical trials as an antitumor compound, based on impressive activities in preclinical models. "	( Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials. Guo, L; Liu, X; Nishikawa, K; Plunkett, W, 2007)
"NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. "	( NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors. Kagaya, S; Miyazaki, O; Nishikawa, K; Okamoto, K; Onda, T; Seno, C; Toyoda, E, 2008)

Compound-Compound Interactions

Excerpt	Reference
"Topoisomerase II (Topo2) inhibitors in combination with cisplatin represent a common treatment modality used for glioma patients."	( Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors. Galita, G; Kopa, P; Macieja, A; Majsterek, I; Pastwa, E; Poplawski, T, 2019)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (42.86)	29.6817
2010's	3 (42.86)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
etoposide [no description available]	7.63	2	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
7-hydroxystaurosporine [no description available]	2.03	1
cannabidiol Cannabidiol: Compound isolated from Cannabis sativa extract.. cannabidiol : An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.	2.21	1	olefinic compound; phytocannabinoid; resorcinols	antimicrobial agent; plant metabolite
staurosporine staurosporinium : Conjugate acid of staurosporine.	2.03	1	ammonium ion derivative
nu 7441 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one: structure in first source	2.63	2	dibenzothiophenes
cannabidiol hydroxyquinone cannabidiol hydroxyquinone: structure given in first source; an air oxidation product of cannabidiol; inhibits the hepatic microsomal drug-metabolizing enzymes of mice through the decrease of cytochrome P-450 content; RN given refers to (1R-trans)-isomer	2.21	1	prenylquinone
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	3.46	7

Condition	Relationship Strength	Studies
Benign Neoplasms, Brain [description not available]	2.63	2
Astrocytoma, Grade IV [description not available]	2.63	2
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.63	2
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	7.63	2
Benign Neoplasms [description not available]	2.44	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.44	2
Leukemia, Lymphocytic, T Cell [description not available]	2.06	1
Leukemia, T-Cell A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.	2.06	1
Ataxia Telangiectasia Syndrome [description not available]	2.06	1
Ataxia Telangiectasia An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).	7.06	1
Abnormalities, Autosome [description not available]	2.03	1
Acute Myelogenous Leukemia [description not available]	2.03	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.03	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2.04	1

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