Compounds > nk314
Page last updated: 2024-10-15

nk314

Description

NK314: a benzo[c]phenanthridine that inhibits topoisomerase IIalpha and G2 cell cycle arrest; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID156596431
MeSH IDM0512543

Synonyms (8)

Synonym
nk314
208237-49-4
1h-(1,3)benzodioxolo(5,6-c)pyrrolo(1,2-f)phenanthridinium, 2,3-dihydro-4-hydroxy-5-methoxy-, chloride (1:1)
1-hydroxy-2-methoxy-11a,13,14,15-tetrahydro-6ah-(1,3)dioxolo(4',5':4,5)benzo(1,2-c)pyrrolo(1,2-f)phenanthridin-12-ium chloride
nk-314
bh68fxm7x8 ,
1h-(1,3)benzodioxolo(5,6-c)pyrrolo(1,2-f)phenanthridinium, 2,3-dihydro-4-hydroxy-5-methoxy-, chloride
unii-bh68fxm7x8

Research Excerpts

Overview

NK314 is a novel synthetic benzo[c]phenanthridine alkaloid. It has recently entered clinical trials as an antitumor compound.

ExcerptReference
"NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that has recently entered clinical trials as an antitumor compound, based on impressive activities in preclinical models. "( Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials.
Guo, L; Liu, X; Nishikawa, K; Plunkett, W, 2007)
"NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. "( NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors.
Kagaya, S; Miyazaki, O; Nishikawa, K; Okamoto, K; Onda, T; Seno, C; Toyoda, E, 2008)

Compound-Compound Interactions

ExcerptReference
"Topoisomerase II (Topo2) inhibitors in combination with cisplatin represent a common treatment modality used for glioma patients."( Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
Galita, G; Kopa, P; Macieja, A; Majsterek, I; Pastwa, E; Poplawski, T, 2019)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
etoposide
[no description available]		7.6320beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
7-hydroxystaurosporine
[no description available]		2.0310
cannabidiol
Cannabidiol: Compound isolated from Cannabis sativa extract.. cannabidiol : An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.		2.2110olefinic compound;
phytocannabinoid;
resorcinols		antimicrobial agent;
plant metabolite
staurosporine
staurosporinium : Conjugate acid of staurosporine.		2.0310ammonium ion derivative
nu 7441
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one: structure in first source		2.6320dibenzothiophenes
cannabidiol hydroxyquinone
cannabidiol hydroxyquinone: structure given in first source; an air oxidation product of cannabidiol; inhibits the hepatic microsomal drug-metabolizing enzymes of mice through the decrease of cytochrome P-450 content; RN given refers to (1R-trans)-isomer		2.2110prenylquinone
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		3.4670
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms, Brain
[description not available]		02.6320
Astrocytoma, Grade IV
[description not available]		02.6320
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.6320
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		07.6320
Benign Neoplasms
[description not available]		02.4420
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.4420
Leukemia, Lymphocytic, T Cell
[description not available]		02.0610
Leukemia, T-Cell
A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.		02.0610
Ataxia Telangiectasia Syndrome
[description not available]		02.0610
Ataxia Telangiectasia
An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).		07.0610
Abnormalities, Autosome
[description not available]		02.0310
Acute Myelogenous Leukemia
[description not available]		02.0310
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		02.0310
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0410