Compounds > aristololactam bii
Page last updated: 2024-12-08

aristololactam bii

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

aristololactam BII: isolated from Saururus cernuus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Saururusgenus[no description available]SaururaceaeA plant family of the order Piperales, subclass Magnoliidae class Magnoliopsida. Members contain sauristolactam, and aristololactam BII.[MeSH]

Cross-References

ID SourceID
PubMed CID162739
CHEMBL ID226772
MeSH IDM0178115

Synonyms (19)

Synonym
dibenz[cd,f]indol-4(5h)-one, 1,2-dimethoxy-
cepharanone b
CHEMBL226772
1,2-dimethoxydibenzo[cd,f]indol-4(5h)-one
53948-09-7
dibenz(cd,f)indol-4(5h)-one, 1,2-dimethoxy-
aristololactam bii
aristolactam bii
AKOS028108642
14,15-dimethoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one
14,15-dimethoxy-10-azatetracyclo[7.6.1.0^{2,7.0^{12,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one
FS-9995
DTXSID80968750
1,2-dimethoxydibenzo[cd,f]indol-4-ol
alkaloid y, from schefferomitra subaequalis; aristolactam b ii; aristolactam b11; aristololactam b ii
B0005-189390
HY-N2893
CS-0023478
aristolactambii
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID284364Selectivity index, ratio of CC50 for BALB/c mouse spleen cells to IC50 for BALB/c mouse T cells2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID284365Selectivity index, ratio of CC50 for BALB/c mouse T cells to IC50 for BALB/c mouse B cells2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID351331Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay2009Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
Synthesis of aristolactam analogues and evaluation of their antitumor activity.
AID284363Inhibition of LPS-induced BALB/c mouse B cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID284361Cytotoxicity against BALB/c mouse spleen cells2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID351329Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay2009Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
Synthesis of aristolactam analogues and evaluation of their antitumor activity.
AID1776041Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay
AID284362Inhibition of ConA-induced BALB/c mouse T cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID351328Antiproliferative activity against human MESSA cells by SRB assay2009Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
Synthesis of aristolactam analogues and evaluation of their antitumor activity.
AID351330Antiproliferative activity against human HCT15 cells by SRB assay2009Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
Synthesis of aristolactam analogues and evaluation of their antitumor activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (63.64)29.6817
2010's3 (27.27)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.79 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.35 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzamide
benzamide : An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.		2.0210benzamides
3-hydroxybutanal
[no description available]		2.0410
indoline
indoline: structure given in first source		2.0210indoles
glaucine
glaucine: RN given refers to (+-)-isomer		2.0310aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound		antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite
alkenes
[no description available]		2.0710
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.0210glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
etoposide
[no description available]		2.0510beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
sauristolactam
sauristolactam: lactam of 10-aminomethyl-3-hydroxy-4-methoxyphenanthrene-1-carboxylic acid isolated from Saururus cernuus; structure given in first source		2.4520
isoteolin
isoteolin: mixture of isomers isoboldine (RN 3019-51-0) & bracteoline (RN 25651-04-1)		2.0310aporphine alkaloid
liridine
liridine: Antibacterial from Artabotrys crassifolius; structure in first source		2.0310
aristololactam a ii
aristololactam A II: from the stems of Uvaria kweichowensis; structure in first source		2.0310
corytuberine
corytuberine: structure. (S)-corytuberine : An aporphine alkaloid that is aporphine which is substituted by hydroxy groups at positions 1 and 11, and by methoxy groups at positions 2 and 10 (the S enantiomer).		2.0310aporphine alkaloid;
aromatic ether;
organic heterotetracyclic compound;
polyphenol;
tertiary amino compound		plant metabolite
norcepharadione b
norcepharadione B: isolated from Houttynia cordata; structure in first source		2.4220
piperolactam a
piperolactam A: isolated from Houttynia cordata; structure in first source		2.9440alkaloid
cyclosporine
ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF		2.0310homodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
pellitorine
pellitorine: consists of piper sylvaticum Roxb.; structure		2.0710fatty amidemetabolite
guineensine
guineensine: an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum; structure in first sourc		2.0710benzodioxoles
aristolactam aiiia
Aristolactam AIIIa: polo-like kinase 1 (Plk1) inhibitor; structure in first source		2.0310
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.0410
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung
[description not available]		02.1710
Lung Neoplasms
Tumors or cancer of the LUNG.		02.1710
Encephalopathy, Toxic
[description not available]		02.0210