Page last updated: 2024-12-08
aristololactam bii
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
aristololactam BII: isolated from Saururus cernuus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Saururus | genus | [no description available] | Saururaceae | A plant family of the order Piperales, subclass Magnoliidae class Magnoliopsida. Members contain sauristolactam, and aristololactam BII.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 162739 |
| CHEMBL ID | 226772 |
| MeSH ID | M0178115 |
Synonyms (19)
| Synonym |
|---|
| dibenz[cd,f]indol-4(5h)-one, 1,2-dimethoxy- |
| cepharanone b |
| CHEMBL226772 |
| 1,2-dimethoxydibenzo[cd,f]indol-4(5h)-one |
| 53948-09-7 |
| dibenz(cd,f)indol-4(5h)-one, 1,2-dimethoxy- |
| aristololactam bii |
| aristolactam bii |
| AKOS028108642 |
| 14,15-dimethoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one |
| 14,15-dimethoxy-10-azatetracyclo[7.6.1.0^{2,7.0^{12,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one |
| FS-9995 |
| DTXSID80968750 |
| 1,2-dimethoxydibenzo[cd,f]indol-4-ol |
| alkaloid y, from schefferomitra subaequalis; aristolactam b ii; aristolactam b11; aristololactam b ii |
| B0005-189390 |
| HY-N2893 |
| CS-0023478 |
| aristolactambii |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID284364 | Selectivity index, ratio of CC50 for BALB/c mouse spleen cells to IC50 for BALB/c mouse T cells | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID284365 | Selectivity index, ratio of CC50 for BALB/c mouse T cells to IC50 for BALB/c mouse B cells | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID351331 | Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11 | Synthesis of aristolactam analogues and evaluation of their antitumor activity. |
| AID284363 | Inhibition of LPS-induced BALB/c mouse B cell proliferation | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID284361 | Cytotoxicity against BALB/c mouse spleen cells | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID351329 | Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11 | Synthesis of aristolactam analogues and evaluation of their antitumor activity. |
| AID1776041 | Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay | |||
| AID284362 | Inhibition of ConA-induced BALB/c mouse T cell proliferation | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID351328 | Antiproliferative activity against human MESSA cells by SRB assay | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11 | Synthesis of aristolactam analogues and evaluation of their antitumor activity. |
| AID351330 | Antiproliferative activity against human HCT15 cells by SRB assay | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11 | Synthesis of aristolactam analogues and evaluation of their antitumor activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (11)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.79
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.79) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||