1-hydroxyphenanthrene profile

1-hydroxyphenanthrene is a **polycyclic aromatic hydrocarbon (PAH)** with a hydroxyl group (-OH) attached at the 1-position of the phenanthrene ring.

Here's why it's important for research:

**1. Biological Activity:**

* **Potential Anti-Cancer Properties:** Studies have shown that 1-hydroxyphenanthrene exhibits potential anti-cancer activity, particularly against certain types of leukemia and lymphoma. It's believed to work by inhibiting the growth and proliferation of cancer cells.
* **Antioxidant Properties:** Like other phenolic compounds, 1-hydroxyphenanthrene has antioxidant properties. This means it can neutralize free radicals, which can damage cells and contribute to diseases like cancer and heart disease.
* **Anti-Inflammatory Properties:** 1-hydroxyphenanthrene has been found to possess anti-inflammatory properties, potentially useful in treating inflammatory conditions.

**2. Environmental Significance:**

* **Environmental Pollutant:** 1-hydroxyphenanthrene is a known environmental pollutant, often found in soil, water, and air, as a result of incomplete combustion of fossil fuels and other industrial processes. Its presence in the environment is a cause for concern due to its potential toxicity to living organisms.
* **Biomarker for Pollution:** 1-hydroxyphenanthrene can serve as a biomarker for environmental pollution, as its levels in various environmental matrices (soil, water, etc.) can indicate the presence of other PAHs and potential health risks.

**3. Analytical Chemistry:**

* **Standard for Analysis:** 1-hydroxyphenanthrene is often used as a reference standard in analytical chemistry for the analysis and quantification of PAHs in environmental samples.

**4. Chemical Synthesis and Reactivity:**

* **Synthetic Intermediate:** 1-hydroxyphenanthrene is a valuable synthetic intermediate in the production of various pharmaceuticals and other fine chemicals.
* **Studies of PAH Reactivity:** The presence of the hydroxyl group in 1-hydroxyphenanthrene allows for the study of the reactivity of PAHs in various chemical reactions and environments.

Overall, 1-hydroxyphenanthrene is a molecule with diverse properties and applications, making it an important subject of research in various fields, including medicine, environmental science, and chemistry. However, its environmental significance and potential toxicity require further investigation and monitoring.

1-hydroxyphenanthrene: a metabolite of polycyclic aromatic hydrocarbon [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	98490
CHEBI ID	27528
SCHEMBL ID	218498
MeSH ID	M0243170

Synonym
nsc44471
1-phenanthrenol
nsc-44471
phenanthren-1-ol
CHEBI:27528
1-hydroxyphenanthrene
1-phenanthrol
2433-56-9
gtbxzwadmkozqj-uhfffaoysa-
inchi=1/c14h10o/c15-14-7-3-6-12-11-5-2-1-4-10(11)8-9-13(12)14/h1-9,15h
30774-95-9
AKOS006272746
nsc 44471
unii-y1ftf7muy7
y1ftf7muy7 ,
ai3-24096
FT-0634273
SCHEMBL218498
1-hydroxy-phenanthrene
GTBXZWADMKOZQJ-UHFFFAOYSA-N
DTXSID90872758
phenanthrol
J-015449
1-phenanthrenol; 1-hydroxyphenanthrene; nsc 44471;
Q18343391

Role	Description
mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
phenanthrol
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (7.14)	18.2507
2000's	1 (7.14)	29.6817
2010's	9 (64.29)	24.3611
2020's	3 (21.43)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbon monoxide Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.	2.08	1	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent
phenanthrene phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'	2.48	2	ortho-fused polycyclic arene; ortho-fused tricyclic hydrocarbon; phenanthrenes	environmental contaminant; mouse metabolite
2-naphthol 2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.	2.61	2	naphthol	antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger
9-phenanthrol 9-phenanthrol: an inhibitor of AMP-dependent protein kinase catalytic subunit; structure in first source. 9-phenanthrol : A phenanthrol that is phenanthrene in which a hydrogen attached to a carbon in the central ring has been replaced by a hydroxy group.	1.98	1	phenanthrol	TRPM4 channel inhibitor
1-hydroxypyrene 1-hydroxypyrene: pyrene metabolite; RN given refers to parent cpd	3.56	8	pyrenes
3-hydroxybenzo(a)pyrene 3-hydroxybenzo(a)pyrene: RN given refers to unlabeled parent cpd	2.02	1	ortho- and peri-fused polycyclic arene
pyrene pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.	2.07	1	ortho- and peri-fused polycyclic arene	fluorescent probe; persistent organic pollutant
fluoren-9-ol fluoren-9-ol : A member of the class of hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon).	2.25	1	hydroxyfluorenes; secondary alcohol	animal metabolite
2-hydroxyfluorene 2-hydroxyfluorene: structure in first source	2.6	1	fluorenes
4-hydroxyphenanthrene 4-hydroxyphenanthrene: a metabolite of polycyclic aromatic hydrocarbon	2.73	3	phenanthrol
cocaine Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.	2.07	1	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	3.95	12

Condition	Relationship Strength	Studies
Long Sleeper Syndrome [description not available]	2.6	1
Sleep Wake Disorders Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.	2.6	1
Innate Inflammatory Response [description not available]	2.17	1
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	2.17	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.17	1
Delayed Effects, Prenatal Exposure [description not available]	2.17	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.52	2
Celiac Sprue [description not available]	2.13	1
Kidney Stones [description not available]	2.13	1
Celiac Disease A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.	2.13	1
Kidney Calculi Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.	2.13	1

1-hydroxyphenanthrene

Description

Cross-References

Synonyms (25)

Roles (1)

Drug Classes (1)

Research

Studies (14)

Market Indicators

Research Demand Index: 20.64

Study Types