Page last updated: 2024-12-07
1-hydroxyphenanthrene
Description
1-hydroxyphenanthrene is a **polycyclic aromatic hydrocarbon (PAH)** with a hydroxyl group (-OH) attached at the 1-position of the phenanthrene ring.
Here's why it's important for research:
**1. Biological Activity:**
* **Potential Anti-Cancer Properties:** Studies have shown that 1-hydroxyphenanthrene exhibits potential anti-cancer activity, particularly against certain types of leukemia and lymphoma. It's believed to work by inhibiting the growth and proliferation of cancer cells.
* **Antioxidant Properties:** Like other phenolic compounds, 1-hydroxyphenanthrene has antioxidant properties. This means it can neutralize free radicals, which can damage cells and contribute to diseases like cancer and heart disease.
* **Anti-Inflammatory Properties:** 1-hydroxyphenanthrene has been found to possess anti-inflammatory properties, potentially useful in treating inflammatory conditions.
**2. Environmental Significance:**
* **Environmental Pollutant:** 1-hydroxyphenanthrene is a known environmental pollutant, often found in soil, water, and air, as a result of incomplete combustion of fossil fuels and other industrial processes. Its presence in the environment is a cause for concern due to its potential toxicity to living organisms.
* **Biomarker for Pollution:** 1-hydroxyphenanthrene can serve as a biomarker for environmental pollution, as its levels in various environmental matrices (soil, water, etc.) can indicate the presence of other PAHs and potential health risks.
**3. Analytical Chemistry:**
* **Standard for Analysis:** 1-hydroxyphenanthrene is often used as a reference standard in analytical chemistry for the analysis and quantification of PAHs in environmental samples.
**4. Chemical Synthesis and Reactivity:**
* **Synthetic Intermediate:** 1-hydroxyphenanthrene is a valuable synthetic intermediate in the production of various pharmaceuticals and other fine chemicals.
* **Studies of PAH Reactivity:** The presence of the hydroxyl group in 1-hydroxyphenanthrene allows for the study of the reactivity of PAHs in various chemical reactions and environments.
Overall, 1-hydroxyphenanthrene is a molecule with diverse properties and applications, making it an important subject of research in various fields, including medicine, environmental science, and chemistry. However, its environmental significance and potential toxicity require further investigation and monitoring.
1-hydroxyphenanthrene: a metabolite of polycyclic aromatic hydrocarbon [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
PubMed CID | 98490 |
CHEBI ID | 27528 |
SCHEMBL ID | 218498 |
MeSH ID | M0243170 |
Synonyms (25)
Synonym |
nsc44471 |
1-phenanthrenol |
nsc-44471 |
phenanthren-1-ol |
CHEBI:27528 |
1-hydroxyphenanthrene |
1-phenanthrol |
2433-56-9 |
gtbxzwadmkozqj-uhfffaoysa- |
inchi=1/c14h10o/c15-14-7-3-6-12-11-5-2-1-4-10(11)8-9-13(12)14/h1-9,15h |
30774-95-9 |
AKOS006272746 |
nsc 44471 |
unii-y1ftf7muy7 |
y1ftf7muy7 , |
ai3-24096 |
FT-0634273 |
SCHEMBL218498 |
1-hydroxy-phenanthrene |
GTBXZWADMKOZQJ-UHFFFAOYSA-N |
DTXSID90872758 |
phenanthrol |
J-015449 |
1-phenanthrenol; 1-hydroxyphenanthrene; nsc 44471; |
Q18343391 |
Roles (1)
Role | Description |
mouse metabolite | Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). |
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (1)
Class | Description |
phenanthrol | |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (14)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (7.14) | 18.2507 |
2000's | 1 (7.14) | 29.6817 |
2010's | 9 (64.29) | 24.3611 |
2020's | 3 (21.43) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 20.64
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 20.64 (24.57) | Research Supply Index | 2.71 (2.92) | Research Growth Index | 5.72 (4.65) | Search Engine Demand Index | 15.26 (26.88) | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 14 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |