1,3-dithiolane profile

1,3-Dithiolane is a heterocyclic organic compound with the formula C3H6S2. It is a colorless liquid with a characteristic odor. 1,3-Dithiolane is a versatile building block in organic synthesis, particularly in the preparation of sulfur-containing compounds. It is also used as a reagent in the synthesis of polymers and pharmaceuticals. The compound is known to be a useful precursor to various sulfur-containing compounds, and its synthesis is often carried out by the reaction of 1,2-dibromoethane with sodium sulfide. 1,3-Dithiolane can act as a protecting group for carbonyl compounds, forming a stable cyclic thioacetal. This property is valuable in organic synthesis, as it allows for the selective modification of carbonyl groups while leaving other functional groups untouched.'

ID Source	ID
PubMed CID	20970
CHEBI ID	38079
SCHEMBL ID	28510
MeSH ID	M0060327

Synonym
nsc193357
1,3-dithiolane
4829-04-3
nsc-193357
1,3-dithiacyclopentane
CHEBI:38079
dithiolane
nsc 193357
inchi=1/c3h6s2/c1-2-5-3-4-1/h1-3h
1,3-dithiolane, 97%
unii-341g58g6yl
341g58g6yl ,
AKOS025293915
SCHEMBL28510
mfcd00041425
DTXSID90197473
Q27117371

Class	Description
dithiolane
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (22.22)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	4 (44.44)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hexobarbital Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.. hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.	1.95	1	barbiturates
methylene blue Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.	2.11	1	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer
decalin decalin: RN given refers to cpd without isomeric designation; don't confuse with decaline which has a nitrogen at the juncture of the two rings;. trans-decalin : The trans-stereoisomer of decalin.. decalin : An ortho-fused bicyclic hydrocarbon that is the decahydro- derivative of naphthalene.	7.06	1	ortho-fused bicyclic hydrocarbon	solvent
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.39	2	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
fluorine Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.	2.02	1	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
alkenes [no description available]	2.06	1
1,3-oxathiolane 1,3-oxathiolane: structure	7.39	2
triptolide [no description available]	7.05	1	diterpenoid; epoxide; gamma-lactam; organic heteroheptacyclic compound	antispermatogenic agent; plant metabolite
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2	1
selectfluor selectfluor: structure in first source	7.02	1
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	2.05	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.05	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.05	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	1.95	1

1,3-dithiolane

Cross-References

Synonyms (17)

Drug Classes (1)

Research

Studies (9)

Market Indicators

Research Demand Index: 39.08

Study Types