3-Chlorobiphenyl (3-CB) is a persistent organic pollutant (POP) that is primarily found in the environment as a result of industrial activities, such as the production of polychlorinated biphenyls (PCBs). 3-CB is a colorless, odorless solid that is highly resistant to degradation and can persist in the environment for long periods of time. It is a known endocrine disruptor and has been linked to adverse health effects in humans and wildlife. 3-CB is studied extensively due to its environmental persistence, bioaccumulation in food chains, and potential for toxic effects. The synthesis of 3-CB involves the reaction of chlorobenzene with biphenyl in the presence of a catalyst, such as aluminum chloride. 3-CB can be found in soil, water, air, and living organisms. It is a contaminant of concern because of its potential to cause a range of health problems, including cancer, reproductive disorders, and developmental delays.'
3-chlorobiphenyl: RN given refers to cpd with specified locant for chlorine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 16322 |
| CHEBI ID | 36716 |
| SCHEMBL ID | 170231 |
| MeSH ID | M0105743 |
| Synonym |
|---|
| 3-chlorobiphenyl |
| biphenyl, 3-chloro- |
| 2051-61-8 |
| 3-monochlorobiphenyl |
| 3-chloro-1,1'-biphenyl |
| CHEBI:36716 , |
| 3-monochloro-1,1'-biphenyl |
| 3-chlorbiphenyl |
| m-chlorobiphenyl |
| 3-chlorodiphenyl |
| einecs 218-126-1 |
| 1,1'-biphenyl, 3-chloro- |
| 11104-28-2 |
| nmwskolwzzwhpl-uhfffaoysa- |
| 1-chloro-3-phenylbenzene |
| inchi=1/c12h9cl/c13-12-8-4-7-11(9-12)10-5-2-1-3-6-10/h1-9h |
| wlq4633sjy , |
| unii-wlq4633sjy |
| 1-chloranyl-3-phenyl-benzene |
| A814631 |
| AKOS006229877 |
| pcb no 2 |
| 3-pcb |
| FT-0615290 |
| 3-chloro[1,1'-biphenyl] |
| 3'-chlorobiphenyl |
| SCHEMBL170231 |
| pcb 2 |
| m-chlorodiphenyl |
| 1,1'-biphenyl, 3-monochloro- |
| 1,1'-biphenyl,3-chloro- |
| DTXSID1040299 , |
| mfcd00013633 |
| pcb 2 (3-chlorobiphenyl) |
| pcb no 2, analytical standard |
| pcb no. 2 10 microg/ml in isooctane |
| pcb no. 2 |
| Q27891531 |
| CS-0204909 |
| arochlor 1221 |
| 3-chloro-biphenyl |
| BS-21894 |
| CAA05161 |
| dtxcid9020299 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Evidence is presented for the application of Raman spectroscopy as a bioassay for pollutant bioavailability and toxicity." | ( Insight into pollutant bioavailability and toxicity using Raman confocal microscopy. Helm, J; Huang, WE; Singer, AC; Thompson, IP, 2005) | 0.33 |
| " F113Rifpcbgfp and F113L::1180gfp are biosensor strains capable of detecting PCB bioavailability and biodegradation." | ( Alginate beads as a storage, delivery and containment system for genetically modified PCB degrader and PCB biosensor derivatives of Pseudomonas fluorescens F113. Brazil, D; Dowling, DN; Germaine, KJ; Liu, X; Power, B; Ryan, D, 2011) | 0.37 |
The total glutathione content (tGSH) was determined. Populations of Tn5271-carrying bacteria were significantly higher in microcosms dosed with 3-chlorobenzoate, 4-chloroaniline, and 3- chlorobiphenyl. This suggests that each of these chemicals exerts a selective force on this particular genotype.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Populations of Tn5271-carrying bacteria were significantly higher in microcosms dosed with 3-chlorobenzoate, 4-chloroaniline, and 3-chlorobiphenyl than in the control microcosms, indicating that each of these chemicals exerts a selective force on this particular genotype in natural systems." | ( Involvement of a chlorobenzoate-catabolic transposon, Tn5271, in community adaptation to chlorobiphenyl, chloroaniline, and 2,4-dichlorophenoxyacetic acid in a freshwater ecosystem. Fulthorpe, RR; Wyndham, RC, 1992) | 0.49 |
| " After 24 h of exposure to various concentrations of 3-chlorobiphenyl, the total glutathione content (tGSH) was determined and the dose-response curves for glutathione reductase (GR) and microsomal/cytosolic glutathione S-transferases (m- and c-GSTs, respectively) were established." | ( Effects of 3-chlorobiphenyl on photosynthetic oxygen production, glutathione content and detoxication enzymes in the aquatic macrophyte Ceratophyllum demersum. Menone, ML; Pflugmacher, S, 2005) | 0.97 |
| Class | Description |
|---|---|
| monochlorobiphenyl | A chlorobiphenyl carrying a single chloro substituent at unspecified position. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.08) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 19 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||