Page last updated: 2024-12-11
isocupressic acid
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
isocupressic acid: a labdane that induces premature LABOR [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 6438138 |
CHEMBL ID | 511193 |
SCHEMBL ID | 13532265 |
MeSH ID | M0287138 |
Synonyms (24)
Synonym |
---|
isocupressic acid |
isocupressicacid |
CHEMBL511193 |
(1s,4ar,5s,8ar)-5-[(e)-5-hydroxy-3-methylpent-3-enyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2h-naphthalene-1-carboxylic acid |
1-naphthalenecarboxylic acid, decahydro-5-((3e)-5-hydroxy-3-methyl-3-pentenyl)-1,4a-dimethyl-6-methylene-, (1s,4ar,5s,8ar)- |
15-hydroxylabda-8(17),13-dien-19-oic acid |
1909-91-7 |
6dv5el78he , |
unii-6dv5el78he |
1-naphthalenecarboxylic acid, decahydro-5-(5-hydroxy-3-methyl-3-pentenyl)-1,4a-dimethyl-6-methylene-, (1s-(1alpha,4aalpha,5alpha(e),8abeta))- |
SCHEMBL13532265 |
AKOS032948527 |
Q15426267 |
labda-8(20),13-dien-19-oic acid, 15-hydroxy-, (e)- (8ci); (1s,4ar,5s,8ar)-decahydro-5-[(3e)-5-hydroxy-3-methyl-3-penten-1-yl]-1,4a-dimethyl-6-methylene-1-naphthalenecarboxylic acid |
HY-N3493 |
CS-0024374 |
(1s,4ar,5s,8ar)-decahydro-5-[(3e)-5-hydroxy-3-methyl-3-penten-1-yl]-1,4a-dimethyl-6-methylene-1-naphthalenecarboxylic acid |
1-naphthalenecarboxylic acid, decahydro-5-(5-hydroxy-3-methyl-3-pentenyl)-1,4a-dimethyl-6-methylene-, (1s-(1.alpha.,4a.alpha.,5.alpha.(e),8a.beta.))- |
(+)-isocupressic acid |
labda-8(20),13-dien-19-oic acid, 15-hydroxy-, (e)- |
isocupressic acid, (+)- |
1-naphthalenecarboxylic acid, decahydro-5-[(3e)-5-hydroxy-3-methyl-3-penten-1-yl]-1,4a-dimethyl-6-methylene-, (1s,4ar,5s,8ar)- |
DTXSID901045341 |
FS-10528 |
Research Excerpts
Dosage Studied
Excerpt | Relevance | Reference |
---|---|---|
" One assay was used to follow the absorption and elimination profile of isocupressic acid metabolites in both cow serum and urine after oral dosage of a cow with common juniper." | ( Development of enzyme-linked immunosorbent assays for isocupressic acid and serum metabolites of isocupressic acid. Gardner, DR; Garrosian, M; Lee, ST; Panter, KE; Schoch, TK; Serrequi, AN; Stegelmeier, BL, 2003) | 0.8 |
" When pine needles are dosed orally to cattle, no ICA is detected in their serum, whereas AGA is readily detected." | ( A comparison of the metabolism of the abortifacient compounds from Ponderosa pine needles in conditioned versus naive cattle. Gardner, DR; Hall, JO; Panter, KE; Pfister, JA; Welch, KD; Zieglar, J, 2012) | 0.38 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (18)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID750854 | Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay | 2013 | Journal of natural products, Jun-28, Volume: 76, Issue:6 | Diterpenoids from the twigs and leaves of Fokienia hodginsii. |
AID1657513 | Anti-inflammatory activity against human neutrophils assessed as inhibition of fMLF/CB-induced superoxide anion generation at 10 uM preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins and measured after 10 mins by spectropho | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10 | |
AID1657512 | Anti-inflammatory activity against human neutrophils assessed as inhibition of fMLF/CB-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins and measured after 10 mins by spectrophotometric | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10 | |
AID401216 | Induction of membrane modification in erythrocytes assessed as formation of discocyte shape change at 12.5 ug/mL after 48 hrs by phase contrast light microscopy | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells. |
AID401212 | Induction of membrane modification in erythrocytes assessed as formation of discocyte shape change at 25 ug/mL after 48 hrs by phase contrast light microscopy | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells. |
AID1657515 | Anti-inflammatory activity against human neutrophils assessed as inhibition in fMLF/CB-induced elastase release at 10 uM preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins and measured after 10 mins by spectrophotometric an | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10 | |
AID750851 | Cytotoxicity against human SW480 cells after 48 hrs by MTT assay | 2013 | Journal of natural products, Jun-28, Volume: 76, Issue:6 | Diterpenoids from the twigs and leaves of Fokienia hodginsii. |
AID750853 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2013 | Journal of natural products, Jun-28, Volume: 76, Issue:6 | Diterpenoids from the twigs and leaves of Fokienia hodginsii. |
AID750855 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2013 | Journal of natural products, Jun-28, Volume: 76, Issue:6 | Diterpenoids from the twigs and leaves of Fokienia hodginsii. |
AID404064 | Cytotoxicity against mouse 26-L5 cells after 24 hrs by MTT assay | 1998 | Journal of natural products, Jul, Volume: 61, Issue:7 | Chemical constituents of Brazilian propolis and their cytotoxic activities. |
AID401198 | Induction of membrane modification in erythrocytes assessed as formation of stomatocyte type 2 shape change at 100 ug/mL after 48 hrs by phase contrast light microscopy | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells. |
AID750852 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2013 | Journal of natural products, Jun-28, Volume: 76, Issue:6 | Diterpenoids from the twigs and leaves of Fokienia hodginsii. |
AID1657510 | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10 | |
AID400961 | Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]phenylalanine uptake | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells. |
AID1657509 | Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10 | |
AID401206 | Induction of membrane modification in erythrocytes assessed as formation of discocyte shape change at 50 ug/mL after 48 hrs by phase contrast light microscopy | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells. |
AID1657511 | Antiproliferative activity against human A549 cells assessed as inhibition of cell viability by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10 | |
AID404063 | Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay | 1998 | Journal of natural products, Jul, Volume: 61, Issue:7 | Chemical constituents of Brazilian propolis and their cytotoxic activities. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (23)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 6 (26.09) | 18.2507 |
2000's | 5 (21.74) | 29.6817 |
2010's | 10 (43.48) | 24.3611 |
2020's | 2 (8.70) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 24.93
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (24.93) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 2 (8.70%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 21 (91.30%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |