omtriptolide profile

omtriptolide: a water-soluble, semisynthetic derivative of PG490 (triptolide) purified from the Chinese herb Tripterygium Wilfordii; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Tripterygium	genus	A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.[MeSH]	Celastraceae	A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH]

ID Source	ID
PubMed CID	6918522
CHEMBL ID	2110669
SCHEMBL ID	16312527
MeSH ID	M0578170

Synonym
unii-d36elm729p
d36elm729p ,
omtriptolide [inn]
pg490-88
195883-06-8
omtriptolide
ym 262
butanedioic acid, mono((3bs,4as,5ar,6r,6as,7as,7bs,8as,8bs)-1,3,3b,4,4a,6,6a,7a,7b,8b,9,10-dodecahydro-8b-methyl-6a-(1-methylethyl)-1-oxotrisoxireno(6,7:8a,9:4b,5)phenanthro(1,2-c)furan-6-yl) ester
4-(((3bs,4as,5ar,6r,6as,7as,7bs,8as,8bs)-6a-isopropyl-8b-methyl-1-oxo-1,3,3b,4,4a,6,6a,7a,7b,8b,9,10-dodecahydrotrisoxireno(6,7:8a,9:4b,5)phenanthro(1,2-c)furan-6-yl)oxy)-4-oxobutanoic acid
omtriptolide [who-dd]
SCHEMBL16312527
CHEMBL2110669
CS-6982
HY-16363
Q27276034
MS-28442
4-[[(1s,2s,4s,5s,7s,8r,9r,11s,13s)-1-methyl-17-oxo-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-8-yl]oxy]-4-oxobutanoic acid
VHA88306
AKOS040742336

Excerpt	Relevance	Reference
" A phase I trial of PG490-88 for solid tumors began recently and safety and optimal dosing data should accrue within the next 12 months."	( PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Chung, C; Fidler, JM; Gao, M; Li, K; Rosen, GD; Ross, JA; Wei, K, 2003)	0.32

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (58.33)	29.6817
2010's	4 (33.33)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.69%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (92.31%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.01	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
irinotecan [no description available]	2.01	1	carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug
triptolide [no description available]	4.09	4	diterpenoid; epoxide; gamma-lactam; organic heteroheptacyclic compound	antispermatogenic agent; plant metabolite
tacrolimus Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.	2.72	3	macrolide lactam	bacterial metabolite; immunosuppressive agent
trelstar Triptorelin Pamoate: A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE with D-tryptophan substitution at residue 6.	2.02	1
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	4.09	4

Condition	Relationship Strength	Studies
Lung Injury, Acute [description not available]	2.21	1
Injury, Ischemia-Reperfusion [description not available]	2.21	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.21	1
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	2.21	1
Rheumatoid Arthritis [description not available]	3.17	1
Benign Neoplasms [description not available]	3.17	1
Age-Related Osteoporosis [description not available]	3.17	1
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	3.17	1
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	3.17	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.17	1
Osteoporosis Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	3.17	1
Acute Kidney Failure [description not available]	2.1	1
Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	2.1	1
Lung Injury, Ventilator-Induced [description not available]	2.07	1
Bronchiolitis, Exudative [description not available]	2.01	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.01	1
Bronchiolitis Obliterans Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.	2.01	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.01	1
Cancer of Colon [description not available]	2.01	1
Cancer of Lung [description not available]	2.01	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.01	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.01	1
Graft-Versus-Host Disease [description not available]	2.41	2
Graft vs Host Disease The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.	2.41	2

omtriptolide

Description

Cross-References

Synonyms (19)

Research Excerpts

Dosage Studied

Research

Studies (12)

Study Types