clematichinenoside AR: Immunosuppressive Agent from Clematidis Radix et Rhizoma [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11434888 |
| CHEMBL ID | 457170 |
| MeSH ID | M000607929 |
| Synonym |
|---|
| CHEMBL457170 |
| clematichinenoside ar |
| 761425-93-8 |
| MS-32225 |
| CS-0032487 |
| HY-N4232 |
| AKOS040760336 |
Clematichinenoside AR (AR) is a saponin extracted for traditional Chinese medicine with the effects of improving the expression of tight junction (TJ) proteins and mediating anti-inflammatory activities.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Clematichinenoside AR (AR) is a saponin extracted for traditional Chinese medicine with the effects of improving the expression of tight junction (TJ) proteins and mediating anti-inflammatory activities. " | ( Clematichinenoside AR ameliorated spontaneous colitis in Il-10 Hu, J; Li, J; Shen, M; Song, X; Wang, Y; Xiang, P; Yu, L; Zhang, X; Zhang, Z; Zhao, H; Zhou, C; Zuo, L, 2019) | 3.4 |
| "Clematichinenoside AR (AR) is a major active ingredient extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including AS." | ( Clematichinenoside AR Alleviates Foam Cell Formation and the Inflammatory Response in Ox-LDL-Induced RAW264.7 Cells by Activating Autophagy. Diao, Y, 2021) | 2.79 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Clematichinenoside AR (AR) has been defined as a major active ingredient of triterpenoid saponins extracted from Clematidis Radix et Rhizoma, which is a traditional Chinese herbal medicine that has long been used in the treatment of rheumatoid arthritis (RA). " | ( Clematichinenoside AR induces immunosuppression involving Treg cells in Peyer׳s patches of rats with adjuvant induced arthritis. Fang, WR; Han, W; Kodithuwakku, ND; Li, FW; Li, YM; Liu, LF; Ma, Y; Xiong, Y, 2014) | 3.29 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID333245 | Cytotoxicity against human HL60 cells at 20 uM after 72 hrs by MTT assay | 2004 | Journal of natural products, Sep, Volume: 67, Issue:9 | Triterpene saponins from the roots of Clematis chinensis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.01) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||