clematichinenoside AR: Immunosuppressive Agent from Clematidis Radix et Rhizoma [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 11434888 |
| CHEMBL ID | 457170 |
| MeSH ID | M000607929 |
| Synonym |
|---|
| CHEMBL457170 |
| clematichinenoside ar |
| 761425-93-8 |
| MS-32225 |
| CS-0032487 |
| HY-N4232 |
| AKOS040760336 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID333245 | Cytotoxicity against human HL60 cells at 20 uM after 72 hrs by MTT assay | 2004 | Journal of natural products, Sep, Volume: 67, Issue:9 ISSN: 0163-3864 | Triterpene saponins from the roots of Clematis chinensis. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| tryptophan | erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan | antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| triptolide | diterpenoid; epoxide; gamma-lactam; organic heteroheptacyclic compound | antispermatogenic agent; plant metabolite | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| beta-escin | 2014 | 2022 | 4.9 | high | 0 | 0 | 0 | 0 | 4 | 3 | |||
| phenanthrenes | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acute Liver Injury, Drug-Induced | 0 | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| Adjuvant Arthritis | 0 | 2014 | 2017 | 8.5 | medium | 0 | 0 | 0 | 0 | 2 | 0 | |
| Arthritis, Rheumatoid | 0 | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| Atherogenesis | 0 | 2021 | 2021 | 3.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| Atherosclerosis | 0 | 2021 | 2021 | 3.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| Chemical and Drug Induced Liver Injury | 0 | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 | |
| Colitis | 0 | 2019 | 2019 | 5.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Disease Exacerbation | 0 | 2014 | 2014 | 10.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Rheumatoid Arthritis | 0 | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| Article | Year |
|---|---|
| Targeting tryptophan metabolism reveals Clematichinenoside AR alleviates triptolide-induced hepatotoxicity. Journal of pharmaceutical and biomedical analysis, , Jan-20, Volume: 208 | 2022 |
| Protective effects of Clematichinenoside AR against inflammation and cytotoxicity induced by human tumor necrosis factor-α. International immunopharmacology, , Volume: 75 | 2019 |
| Article | Year |
|---|---|
| Dose-response characteristics of Clematis triterpenoid saponins and clematichinenoside AR in rheumatoid arthritis rats by liquid chromatography/mass spectrometry-based serum and urine metabolomics. Journal of pharmaceutical and biomedical analysis, , Mar-20, Volume: 136 | 2017 |
| Article | Year |
|---|---|
| Dose-response characteristics of Clematis triterpenoid saponins and clematichinenoside AR in rheumatoid arthritis rats by liquid chromatography/mass spectrometry-based serum and urine metabolomics. Journal of pharmaceutical and biomedical analysis, , Mar-20, Volume: 136 | 2017 |