Leukostasis

Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.

Synonym
Leukostasis
Leukostasis Syndrome

Excerpt	Reference
"The leukostasis is accompanied by the up-regulation of intercellular adhesion molecule-1 expression in the retina."	( Adamis, AP; Aiello, LP; Bursell, SE; Khosrof, S; Miyamoto, K; Moromizato, Y; Ogura, Y, 2000)
"Pulmonary leukostasis is a rare but serious and often fatal complication of chronic myeloid leukemia (CML) in blast crisis and acute myeloid leukemia."	( Curtin, PT; Druker, BJ; Leis, JF; Maziarz, RT; Primack, SL; Schubach, SE, 2004)
"Leukostasis is one of the complications of CML, causing partial or total occlusion of microvasculature with a variety of clinical manifestations, mostly ophthalmic, neurologic or respiratory."	( Lavie, M; Rottenstreich, A; Rottenstreich, M, 2015)
"Leukostasis is a medical emergency requiring intensive care unit (ICU) admission and its management includes aggressive hydration, prevention and treatment of tumor lysis syndrome, cytoreduction, and leukapheresis."	( Dabrowski, L; Sidhu, G; Singh Lubana, S; Singh, N, 2020)
"Leukostasis is a life-threatening complication of high concentrations of circulating leukemic cells, most often myeloblasts."	( Macaron, W; Sargsyan, Z; Short, NJ, 2022)

Excerpt	Reference
"Rosuvastatin treatment prevented leukostasis when both recipient and donor were treated but not when donor mice only were treated."	( Cotter, M; Forrester, JV; Manivannan, A; Serra, AM; Waddell, J; Xu, H, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	4 (4.94)	12.5806
2000's	27 (33.33)	18.1394
2010's	45 (55.56)	28.8240
2020's	5 (6.17)	9.53

Drug	Relationship Strength	Studies
hydrochloric acid	low	1
lactic acid	low	1
thioctic acid	low	1
pyruvaldehyde	low	1
pyridoxal phosphate	low	1
acetovanillone	low	2
chlorambucil	low	1
fenofibrate	low	4
gliclazide	low	1
hydroxyurea	low	5
losartan	low	3
nifedipine	low	1
prednisolone	low	1
spironolactone	low	1
aldosterone	low	1
mannitol	low	1
cytarabine	low	6
valine	low	1
triamcinolone acetonide	low	2
acrylonitrile	low	1
pyrroles	low	1
thiophenes	low	1
indazoles	low	1
thiazoles	low	1
pyrazines	low	1
evans blue	low	1
fluorobenzenes	low	1
acetylcysteine	low	1
tetramethylpyrazine	low	1
sodium hydroxide	low	1
d-alpha tocopherol	low	1
fluorescein-5-isothiocyanate	low	3
daunorubicin	low	2
etoposide	low	2
ng-nitroarginine methyl ester	low	1
captopril	low	1
colforsin	low	1
valsartan	low	1
acridine orange	low	4
fenofibric acid	low	2
nipradilol	low	1
rosiglitazone	low	1
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	1
peroxynitrous acid	low	1
imatinib mesylate	low	7
ruboxistaurin	low	1
an-69	low	1
bradykinin, sar-(d-phe(8))des-arg(9)	low	1
angiotensin ii	low	4
carboplatin	low	2
fibrin	low	1
bradykinin	low	2
tretinoin	low	2
melphalan	low	1
retinaldehyde	low	3
sesquiterpenes	low	1
curcumin	low	2
dasatinib	low	1
pd 123319	low	1
semaxinib	low	1
ramipril	low	1
puerarin	low	1
fumarates	low	1
tanespimycin	low	1
pazopanib	low	1
cytochrome c-t	low	1
oligonucleotides	low	1
ft011	low	1
incb-018424	low	1
interleukin-8	low	1
gsk0660	low	1
phosphomannopentaose sulfate	low	1
transforming growth factor beta	low	1
cyclin d1	low	1
lewis x antigen	low	1
vitamin b 12	low	1
ecallantide	low	1
silybin	low	1
folic acid	low	1
allopurinol	low	1
eye	low	1
concanavalin a	low	3
phenanthrenes	low	1

Protein Targets (1,230)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Cruzipain	5	0	0	5
regulator of G-protein signaling 4	6	0	0	6
Platelet-activating factor receptor	1	2	0	4
Inositol monophosphatase 1	5	0	0	5
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
TDP1 protein	22	0	0	22
chromobox protein homolog 1	11	0	0	11
geminin	21	0	0	21
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
acetylcholinesterase	11	0	0	11
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	5	0	0	5
pregnane X receptor	7	0	0	7
phosphopantetheinyl transferase	12	0	0	12
RAR-related orphan receptor gamma	20	0	0	20
USP1 protein, partial	14	0	0	14
NFKB1 protein, partial	4	0	0	4
Microtubule-associated protein tau	11	0	0	11
Thrombopoietin	4	0	0	4
AR protein	34	0	0	34
glucocorticoid receptor [Homo sapiens]	23	0	0	23
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
retinoid X nuclear receptor alpha	20	0	0	20
farnesoid X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	34	0	0	34
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	19	0	0	19
Bloom syndrome protein isoform 1	10	0	0	10
D(1A) dopamine receptor	3	0	0	3
thyroid hormone receptor beta isoform a	8	0	0	8
thyroid hormone receptor beta isoform 2	22	0	0	22
heat shock protein beta-1	10	0	0	10
flap endonuclease 1	3	0	0	3
peripheral myelin protein 22	13	0	0	13
survival motor neuron protein isoform d	8	0	0	8
muscarinic acetylcholine receptor M1	4	0	0	4
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	3	0	0	3
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	18	0	0	18
Histone deacetylase 8	0	5	0	5
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	11	0	0	11
Telomerase reverse transcriptase	0	1	0	1
Amyloid-beta precursor protein	0	4	0	5
Reverse transcriptase/RNaseH	0	2	0	2
GLI family zinc finger 3	22	0	0	22
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
thyroid stimulating hormone receptor	9	0	0	9
Cellular tumor antigen p53	25	0	0	25
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	5	3	9
Androgen receptor	0	4	0	5
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
interleukin 8	4	0	0	4
estrogen receptor 2 (ER beta)	15	0	0	15
progesterone receptor	18	0	0	18
estrogen-related nuclear receptor alpha	24	0	0	24
IDH1	7	0	0	7
transcriptional regulator ERG isoform 3	3	0	0	3
ras-related protein Rab-9A	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
lamin isoform A-delta10	15	0	0	15
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	19
Polyphenol oxidase 2	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Bile salt export pump	0	21	0	21
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Glutamate receptor 2	17	0	0	17
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	1	1	2
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	8	0	0	8
Canalicular multispecific organic anion transporter 1	0	19	0	20
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
glucocerebrosidase	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	6	3	9
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	6	0	6
Type-1 angiotensin II receptor	0	7	4	14
Type-2 angiotensin II receptor	0	5	0	5
Type-2 angiotensin II receptor	0	5	0	5
Angiotensin-converting enzyme	0	5	1	7
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
thioredoxin glutathione reductase	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
Metallo-beta-lactamase type 2	0	1	1	2
peripheral myelin protein 22 isoform 1	6	0	0	6
M-phase phosphoprotein 8	5	0	0	5
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Prothrombin	0	1	0	2
Renin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	2	0	2
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	3	0	4
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	3	4	7
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Beta-lactamase class B VIM-2	0	1	1	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
G	11	0	0	11
cytochrome P450 2D6	8	0	0	8
vitamin D3 receptor isoform VDRA	8	0	0	8
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
Interferon beta	16	0	0	16
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
Inositol hexakisphosphate kinase 1	11	0	0	11
cytochrome P450 2C9, partial	11	0	0	11
Luciferase	12	0	0	12
thioredoxin reductase	10	0	0	10
GALC protein	2	0	0	2
GLS protein	8	0	0	8
caspase 7, apoptosis-related cysteine protease	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
EWS/FLI fusion protein	11	0	0	12
pregnane X nuclear receptor	20	0	0	20
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
peroxisome proliferator-activated receptor delta	18	0	0	18
caspase-3	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
activating transcription factor 6	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
Histone H2A.x	12	0	0	12
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
muscleblind-like protein 1 isoform 1	3	0	0	3
Carbonic anhydrase 12	0	1	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	4	0	5
Cytochrome P450 2D6	0	3	1	4
Nuclear receptor ROR-gamma	6	1	1	8
Spike glycoprotein	10	0	1	11
Carbonic anhydrase 9	0	4	0	5
ATPase family AAA domain-containing protein 5	16	0	0	16
Solute carrier organic anion transporter family member 1B3	0	6	0	6
glp-1 receptor, partial	8	0	0	8
peroxisome proliferator activated receptor gamma	16	0	0	16
aryl hydrocarbon receptor	14	0	0	14
thyroid stimulating hormone receptor	11	0	0	11
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
ATP-dependent translocase ABCB1	0	6	0	9
5-hydroxytryptamine receptor 1A	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Ferritin light chain	6	0	0	6
Nrf2	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
SMAD family member 2	8	0	0	8
ATAD5 protein, partial	4	0	0	4
SMAD family member 3	8	0	0	8
alkaline phosphatase, intestinal	0	1	0	1
Smad3	6	0	0	6
apical membrane antigen 1, AMA1	1	0	0	1
PINK1	1	0	0	1
Parkin	3	0	0	3
toll-like receptor 9	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
lysosomal alpha-glucosidase preproprotein	2	0	0	2
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
perilipin-5	0	2	0	2
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	2	0	2
huntingtin isoform 2	3	0	0	3
importin subunit beta-1 isoform 1	4	0	0	4
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	3	0	0	3
mitogen-activated protein kinase 1	5	0	0	5
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
snurportin-1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	6	0	0	6
nuclear receptor ROR-gamma isoform 1	8	0	0	8
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
cytochrome P450 3A4 isoform 1	10	0	0	10
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	1	0	3
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
hypothetical protein SA1422	0	1	0	1
lethal factor (plasmid)	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	10	0	1	11
Prostaglandin E synthase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Acetylcholinesterase	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Integrin beta-3	5	0	0	5
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Cholinesterase	0	2	0	2
Heme oxygenase 1	0	1	0	1
Integrin alpha-IIb	5	0	0	5
Glutathione S-transferase P	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
60 kDa chaperonin	0	3	0	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	10	0	1	11
Alpha-1B adrenergic receptor	0	7	0	7
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	10	0	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	10	0	1	11
Amine oxidase [flavin-containing] A	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Acetylcholinesterase	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	10	0	1	11
Heme oxygenase 2	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] B	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Proteasome subunit beta type-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	10	0	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-6	10	0	1	11
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-synuclein	2	3	1	6
Alpha-1A adrenergic receptor	0	7	0	7
Histamine H2 receptor	4	0	0	4
Glycogen synthase kinase-3 beta	0	1	4	5
Caspase-7	1	0	0	1
Beta-secretase 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	10	0	1	11
Gamma-aminobutyric acid receptor subunit beta-3	10	0	1	11
Gamma-aminobutyric acid receptor subunit beta-2	10	0	1	11
Cholinesterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	4	5
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thiosulfate sulfurtransferase	0	3	0	3
Thioredoxin reductase 1, cytoplasmic	0	2	0	2
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Thioredoxin reductase 3	0	2	0	2
Sortase A	0	1	0	1
GABA theta subunit	10	0	1	11
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	10	0	1	11
Thioredoxin reductase 2, mitochondrial	0	2	0	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
endonuclease IV	2	0	0	2
67.9K protein	6	0	0	6
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
serine/threonine-protein kinase mTOR isoform 1	7	0	0	7
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	2	0	3
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	1	0	2
Cytochrome P450 3A4	0	4	2	7
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	4	6
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	1	0	0	1
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Leukotriene C4 synthase	0	0	4	4
Fumarate hydratase	6	0	0	6
PPM1D protein	5	0	0	5
polyprotein	6	0	0	6
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
tyrosine-protein kinase Yes	4	0	0	4
Bone morphogenetic protein receptor type-1B	0	0	4	4
Membrane-associated progesterone receptor component 1	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	4	5
Serine/threonine-protein kinase PLK4	0	0	4	4
Serine/threonine-protein kinase 25	0	0	4	4
ATP-dependent RNA helicase DDX3X	0	0	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	4	4
Pyridoxal kinase	0	0	4	4
Citron Rho-interacting kinase	0	0	4	4
Serine/threonine-protein kinase RIO3	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 7	0	0	4	4
Serine/threonine-protein kinase Chk1	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	4	5
Peripheral plasma membrane protein CASK	0	0	4	4
Aurora kinase A	0	1	4	5
Cyclin-G-associated kinase	0	1	4	5
Serine/threonine-protein kinase DCLK1	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	1	4	5
Muscle, skeletal receptor tyrosine-protein kinase	0	0	4	4
Ephrin type-B receptor 6	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 3	0	0	4	4
Mitogen-activated protein kinase 13	0	1	4	5
Transmembrane protease serine 2	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	1	4	5
Mitogen-activated protein kinase kinase kinase 13	0	0	4	4
Death-associated protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 7	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 2	0	2	4	6
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	4	4
NUAK family SNF1-like kinase 1	0	0	4	4
Dynamin-like 120 kDa protein, mitochondrial	0	0	4	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	4	4
Tyrosine-protein kinase JAK2	0	2	5	7
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	4	4
Serine/threonine-protein kinase ULK1	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	4	4
Ribosomal protein S6 kinase alpha-5	0	0	4	4
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	4	4
Ribosomal protein S6 kinase alpha-4	0	0	4	4
Serine/threonine-protein kinase 16	0	0	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	4	4
Serine/threonine-protein kinase PAK 3	0	0	4	4
Cyclin-dependent kinase-like 5	0	0	4	4
Serine/threonine-protein kinase 17B	0	0	4	4
Serine/threonine-protein kinase 10	0	0	4	4
Serine/threonine-protein kinase D3	0	0	4	4
Cyclin-dependent kinase 14	0	0	4	4
Structural maintenance of chromosomes protein 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase OSR1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	4	4
Serine/threonine-protein kinase LATS1	0	0	4	4
Serine/threonine-protein kinase PAK 4	0	0	4	4
Serine/threonine-protein kinase Chk2	0	0	4	4
Tyrosine-protein kinase ABL1	0	7	6	14
Tyrosine-protein kinase ABL1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Epidermal growth factor receptor	0	2	4	6
Transthyretin	0	1	1	2
RAF proto-oncogene serine/threonine-protein kinase	0	1	4	5
Receptor tyrosine-protein kinase erbB-2	0	3	4	7
High affinity nerve growth factor receptor	0	0	4	4
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	4	4
ADP/ATP translocase 2	0	0	4	4
Cytochrome P450 1A2	0	3	1	4
Protein kinase C beta type	0	1	4	5
Insulin receptor	0	1	4	5
Tyrosine-protein kinase Lck	0	3	4	7
Proto-oncogene tyrosine-protein kinase LCK	0	2	0	2
Tyrosine-protein kinase Fyn	0	2	4	6
Cyclin-dependent kinase 1	0	2	4	6
Glycogen phosphorylase, liver form	0	0	4	4
Tyrosine-protein kinase Fes/Fps	0	0	4	4
Macrophage colony-stimulating factor 1 receptor	0	4	4	8
Procathepsin L	0	0	1	1
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	1	4	5
Tyrosine-protein kinase Lyn	0	1	4	5
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	4	6
Insulin-like growth factor 1 receptor	0	2	4	6
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	4	4
Hepatocyte growth factor receptor	0	0	4	4
Tyrosine-protein kinase HCK	0	2	4	6
Proto-oncogene tyrosine-protein kinase ROS	0	0	4	4
Platelet-derived growth factor receptor beta	0	4	4	8
Tyrosine-protein kinase Fgr	0	0	4	4
Quinolone resistance protein NorA	0	1	0	1
Wee1-like protein kinase 2	0	0	4	4
Uncharacterized serine/threonine-protein kinase SBK3	0	0	4	4
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	4	4
Mast/stem cell growth factor receptor Kit	0	4	5	9
Glycogen phosphorylase, brain form	0	0	4	4
Breakpoint cluster region protein	0	3	6	10
Serine/threonine-protein kinase pim-1	0	1	4	5
Fibroblast growth factor receptor 1	0	3	4	7
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	5	2	7
Myosin light chain kinase, smooth muscle	0	0	3	3
Cyclin-dependent kinase 4	0	0	4	4
ADP/ATP translocase 3	0	0	4	4
Inosine-5'-monophosphate dehydrogenase 2	0	0	4	4
Proto-oncogene tyrosine-protein kinase Src	0	5	4	9
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	4	4
Insulin receptor-related protein	0	0	4	4
Serine/threonine-protein kinase B-raf	0	0	4	4
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	4	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	4	4
Platelet-derived growth factor receptor alpha	0	5	5	10
Tyrosine-protein kinase Blk	0	1	0	1
Tyrosine-protein kinase Fer	0	0	4	4
Protein kinase C alpha type	0	2	4	6
cAMP-dependent protein kinase catalytic subunit alpha	0	0	4	4
Vascular endothelial growth factor receptor 1	0	2	4	6
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	4	4
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	4	4
Casein kinase II subunit alpha'	0	0	4	4
Ras-related protein Rab-6A	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	4	4
Cytochrome P450 2B6	0	1	0	1
Cyclin-dependent kinase 11B	0	0	4	4
Ephrin type-A receptor 1	0	0	4	4
Fibroblast growth factor receptor 2	0	2	4	6
Receptor tyrosine-protein kinase erbB-3	0	0	4	4
Multifunctional protein ADE2	0	0	4	4
Fibroblast growth factor receptor 4	0	1	4	5
Fibroblast growth factor receptor 3	0	1	4	5
cAMP-dependent protein kinase catalytic subunit gamma	0	0	4	4
cAMP-dependent protein kinase catalytic subunit beta	0	0	4	4
Ferrochelatase, mitochondrial	0	0	4	4
Ribosomal protein S6 kinase beta-1	0	0	4	4
Tyrosine-protein kinase JAK1	0	2	5	7
Protein kinase C eta type	0	1	4	5
Cyclin-dependent kinase 2	0	2	4	6
Beta-adrenergic receptor kinase 1	0	0	4	4
Probable ATP-dependent RNA helicase DDX6	0	0	4	4
Activin receptor type-2A	0	0	4	4
Mitogen-activated protein kinase 3	0	0	4	4
MAP/microtubule affinity-regulating kinase 3	0	0	4	4
Mitogen-activated protein kinase 1	0	1	4	5
Ephrin type-A receptor 2	0	1	4	5
Ephrin type-A receptor 3	0	0	4	4
Ephrin type-A receptor 8	0	0	4	4
Ephrin type-B receptor 2	0	1	4	5
Leukocyte tyrosine kinase receptor	0	0	4	4
Non-receptor tyrosine-protein kinase TYK2	0	2	5	7
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	4	4
Wee1-like protein kinase	0	0	4	4
Heme oxygenase 2	0	0	4	4
Tyrosine-protein kinase receptor UFO	0	0	4	4
Mitogen-activated protein kinase 4	0	0	4	4
S-adenosylmethionine synthase isoform type-2	0	0	4	4
DnaJ homolog subfamily A member 1	0	0	4	4
RAC-alpha serine/threonine-protein kinase	0	2	4	6
RAC-beta serine/threonine-protein kinase	0	1	4	5
G protein-coupled receptor kinase 4	0	0	4	4
Cytochrome P450 2C19	0	2	1	3
Dual specificity protein kinase TTK	0	0	4	4
DNA replication licensing factor MCM4	0	0	4	4
Tyrosine-protein kinase receptor Tie-1	0	0	4	4
Vascular endothelial growth factor receptor 3	0	2	4	6
Vascular endothelial growth factor receptor 2	0	3	4	8
Dual specificity mitogen-activated protein kinase kinase 2	0	1	4	5
Receptor-type tyrosine-protein kinase FLT3	0	2	4	6
Bone morphogenetic protein receptor type-1A	0	0	4	4
Activin receptor type-1B	0	0	4	4
TGF-beta receptor type-1	0	0	4	4
Serine/threonine-protein kinase receptor R3	0	0	4	4
TGF-beta receptor type-2	0	0	4	4
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	1	4	5
Glycine--tRNA ligase	0	0	4	4
Protein kinase C iota type	0	0	4	4
Exosome RNA helicase MTR4	0	0	4	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	4	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	4	5
Serine/threonine-protein kinase mTOR	0	1	4	5
Megakaryocyte-associated tyrosine-protein kinase	0	0	4	4
Tyrosine-protein kinase Tec	0	1	4	5
Tyrosine-protein kinase TXK	0	1	4	5
Tyrosine-protein kinase ABL2	0	0	4	4
Tyrosine-protein kinase FRK	0	0	4	4
G protein-coupled receptor kinase 6	0	0	2	2
Tyrosine-protein kinase ZAP-70	0	1	4	5
Tyrosine-protein kinase SYK	0	1	4	5
26S proteasome regulatory subunit 6B	0	0	4	4
Mitogen-activated protein kinase 8	0	0	4	4
Mitogen-activated protein kinase 9	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 4	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 3	0	0	4	4
Casein kinase I isoform alpha	0	1	4	5
Casein kinase I isoform delta	0	0	4	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	4	5
MAP kinase-activated protein kinase 2	0	1	4	5
Cyclin-dependent kinase 8	0	0	4	4
Elongation factor Tu, mitochondrial	0	0	4	4
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	4	4
Casein kinase I isoform epsilon	0	0	4	4
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	4	4
Dual specificity protein kinase CLK1	0	0	4	4
Dual specificity protein kinase CLK2	0	0	4	4
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	4	4
Cyclin-dependent kinase 7	0	0	4	4
Cyclin-dependent kinase 9	0	0	4	4
Ras-related protein Rab-27A	0	0	4	4
Tyrosine-protein kinase Blk	0	1	4	5
Interleukin-1 receptor-associated kinase 1	0	0	4	4
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Ribosomal protein S6 kinase alpha-3	0	1	4	5
Cytoplasmic tyrosine-protein kinase BMX	0	0	4	4
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	4	4
Serine/threonine-protein kinase Nek2	0	0	4	4
Serine/threonine-protein kinase Nek3	0	0	4	4
Serine/threonine-protein kinase Nek4	0	0	4	4
Tyrosine-protein kinase JAK3	0	2	4	6
Dual specificity mitogen-activated protein kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase PLK1	0	0	4	4
Death-associated protein kinase 1	0	0	4	4
LIM domain kinase 1	0	1	4	5
LIM domain kinase 2	0	1	4	5
Mitogen-activated protein kinase 12	0	1	4	5
Mitogen-activated protein kinase 10	0	0	4	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-1	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	4	4
Ephrin type-B receptor 3	0	0	4	4
Ephrin type-A receptor 5	0	0	4	4
Ephrin type-B receptor 4	0	1	4	5
Ephrin type-B receptor 1	0	0	4	4
Ephrin type-A receptor 4	0	0	4	4
Adenylate kinase 2, mitochondrial	0	0	4	4
Adenosine kinase	0	0	4	4
Hormonally up-regulated neu tumor-associated kinase	0	0	4	4
Serine/threonine-protein kinase SIK1	0	2	4	6
Receptor-interacting serine/threonine-protein kinase 4	0	0	4	4
Ras-related protein Rab-10	0	0	4	4
Cell division control protein 2 homolog	0	0	4	4
Actin-related protein 3	0	0	4	4
Actin-related protein 2	0	0	4	4
Calcium-dependent protein kinase 1	0	0	4	4
GTP-binding nuclear protein Ran	0	0	4	4
Tubulin alpha-1A chain	0	0	3	3
Casein kinase II subunit alpha	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	4	4
SRSF protein kinase 2	0	0	4	4
Casein kinase I isoform gamma-2	0	0	4	4
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Mitogen-activated protein kinase kinase kinase 9	0	0	4	4
Serine/threonine-protein kinase PknB	0	0	4	4
Cyclin-dependent kinase 3	0	0	4	4
Cyclin-dependent kinase-like 1	0	0	4	4
Cyclin-dependent kinase 6	0	0	4	4
Cyclin-dependent-like kinase 5	0	0	4	4
Cyclin-dependent kinase 16	0	0	4	4
Cyclin-dependent kinase 17	0	0	4	4
Myelin transcription factor 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
ATP-dependent 6-phosphofructokinase, platelet type	0	0	4	4
Protein kinase C epsilon type	0	1	4	5
Dual specificity mitogen-activated protein kinase kinase 1	0	1	4	5
Angiopoietin-1 receptor	0	1	4	5
Mitogen-activated protein kinase kinase kinase 10	0	0	4	4
DNA topoisomerase 2-beta	0	1	5	12
Protein kinase C theta type	0	0	4	4
Activin receptor type-1	0	0	4	4
Macrophage-stimulating protein receptor	0	1	4	5
Focal adhesion kinase 1	0	1	4	5
Protein kinase C zeta type	0	2	1	3
Protein kinase C delta type	0	2	4	6
Tyrosine-protein kinase BTK	0	2	4	6
Tyrosine-protein kinase receptor TYRO3	0	0	4	4
Cyclin-dependent kinase 18	0	0	4	4
Activated CDC42 kinase 1	0	1	4	5
Epithelial discoidin domain-containing receptor 1	0	3	4	7
Tyrosine-protein kinase ITK/TSK	0	1	4	5
Myotonin-protein kinase	0	0	4	4
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase 12	0	0	4	4
Tyrosine-protein kinase Mer	0	0	4	4
Serine/threonine-protein kinase 4	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase 7	0	0	4	4
Serine/threonine-protein kinase PAK 2	0	0	4	4
Serine/threonine-protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 1	0	0	4	4
cGMP-dependent protein kinase 2	0	0	4	4
Integrin-linked protein kinase	0	0	4	4
Rho-associated protein kinase 1	0	0	4	4
Non-receptor tyrosine-protein kinase TNK1	0	0	4	4
Serine/threonine-protein kinase PRP4 homolog	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 1	0	1	4	5
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	4	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Activin receptor type-2B	0	0	4	4
Bone morphogenetic protein receptor type-2	0	0	4	4
Protein-tyrosine kinase 6	0	1	4	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	4
cGMP-dependent protein kinase 1	0	0	4	4
Cyclin-dependent kinase 13	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	4	4
Protein-tyrosine kinase 2-beta	0	0	4	4
Sodium channel protein type 5 subunit alpha	0	2	0	2
Maternal embryonic leucine zipper kinase	0	0	4	4
Structural maintenance of chromosomes protein 1A	0	0	4	4
Chromodomain-helicase-DNA-binding protein 4	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 1	0	0	3	3
Serine/threonine-protein kinase D1	0	0	4	4
Serine/threonine-protein kinase 38	0	0	4	4
Receptor tyrosine-protein kinase erbB-4	0	0	4	4
Ribosomal protein S6 kinase alpha-2	0	0	4	4
Ephrin type-A receptor 7	0	0	4	4
Delta(24)-sterol reductase	0	0	4	4
Ribosomal protein S6 kinase alpha-1	0	1	4	5
Dual specificity testis-specific protein kinase 1	0	0	4	4
Myosin light chain kinase, smooth muscle	0	1	4	5
Mitogen-activated protein kinase 11	0	1	4	5
Serine/threonine-protein kinase STK11	0	0	4	4
Rhodopsin kinase GRK1	0	0	4	4
NT-3 growth factor receptor	0	0	4	4
Serine/threonine-protein kinase N1	0	0	4	4
Serine/threonine-protein kinase N2	0	0	4	4
Mitogen-activated protein kinase 14	0	1	5	6
Calcium/calmodulin-dependent protein kinase type IV	0	0	4	4
Mitogen-activated protein kinase kinase kinase 11	0	0	4	4
BDNF/NT-3 growth factors receptor	0	0	4	4
Mitogen-activated protein kinase 6	0	0	4	4
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	4	4
Discoidin domain-containing receptor 2	0	3	4	7
AP2-associated protein kinase 1	0	1	4	5
Myosin light chain kinase 3	0	0	4	4
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	4	4
Mitogen-activated protein kinase kinase kinase 19	0	0	4	4
Putative heat shock protein HSP 90-beta 2	0	0	4	4
Serine/threonine-protein kinase TNNI3K	0	0	4	4
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	4	4
Serine/threonine-protein kinase MRCK alpha	0	0	4	4
Serine/threonine-protein kinase MRCK gamma	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	4	4
Serine/threonine-protein kinase Nek5	0	0	4	4
Serine/threonine-protein kinase N3	0	0	3	3
Breakpoint cluster region protein	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	4	4
Dual serine/threonine and tyrosine protein kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 15	0	0	4	4
Uncharacterized protein FLJ45252	0	0	4	4
Acyl-CoA dehydrogenase family member 11	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	4	4
Serine/threonine-protein kinase MARK2	0	0	4	4
Serine/threonine-protein kinase TAO1	0	0	4	4
STE20-related kinase adapter protein alpha	0	0	4	4
Myosin-14	0	0	3	3
AarF domain-containing protein kinase 1	0	0	4	4
Serine/threonine-protein kinase tousled-like 2	0	0	4	4
Serine/threonine-protein kinase 32C	0	0	4	4
Serine/threonine-protein kinase pim-3	0	0	4	4
ATP-dependent RNA helicase DDX42	0	0	2	2
Serine/threonine-protein kinase VRK2	0	0	4	4
Myosin light chain kinase family member 4	0	0	4	4
Homeodomain-interacting protein kinase 1	0	1	4	5
Calcium/calmodulin-dependent protein kinase type 1D	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	4	4
Cyclin-dependent kinase-like 3	0	0	4	4
MAP kinase-activated protein kinase 5	0	0	4	4
Serine/threonine-protein kinase BRSK2	0	0	4	4
Serine/threonine-protein kinase NIM1	0	0	4	4
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	4	4
Misshapen-like kinase 1	0	0	4	4
Serine/threonine-protein kinase DCLK2	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	4	4
Casein kinase I isoform alpha-like	0	0	4	4
Homeodomain-interacting protein kinase 4	0	1	4	5
Myosin-IIIa	0	0	4	4
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	4	4
Serine/threonine-protein kinase Nek11	0	0	4	4
Atypical kinase COQ8A, mitochondrial	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	4	4
Mitogen-activated protein kinase 15	0	0	4	4
Serine/threonine-protein kinase Nek9	0	0	4	4
Serine/threonine-protein kinase BRSK1	0	0	4	4
Serine/threonine-protein kinase 35	0	0	4	4
Serine/threonine-protein kinase Nek7	0	0	4	4
Rhodopsin kinase GRK7	0	0	4	4
Serine/threonine-protein kinase 32A	0	0	4	4
Myosin-IIIb	0	0	4	4
ATP-dependent RNA helicase DDX1	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	4	4
Cyclin-dependent kinase-like 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	4	4
Serine/threonine-protein kinase Sgk3	0	0	4	4
Atypical kinase COQ8B, mitochondrial	0	0	4	4
Aurora kinase B	0	1	4	5
MAP/microtubule affinity-regulating kinase 4	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Serine/threonine-protein kinase Nek1	0	0	4	4
Cyclin-dependent kinase 15	0	0	4	4
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	4	4
EKC/KEOPS complex subunit TP53RK	0	0	4	4
Dual specificity testis-specific protein kinase 2	0	0	2	2
SRSF protein kinase 1	0	0	4	4
Protein cereblon	0	0	1	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	2	4	6
Mitogen-activated protein kinase kinase kinase 5	0	0	4	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	4	4
Mitogen-activated protein kinase kinase kinase 3	0	0	4	4
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	4	4
Serine/threonine-protein kinase RIO1	0	0	4	4
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase RIO2	0	0	4	4
Cyclin-dependent kinase 19	0	0	4	4
Transient receptor potential cation channel subfamily M member 6	0	0	4	4
Testis-specific serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase 33	0	0	4	4
Nucleolar GTP-binding protein 1	0	0	4	4
Serine/threonine-protein kinase D2	0	0	4	4
Serine/threonine-protein kinase DCLK3	0	0	4	4
NUAK family SNF1-like kinase 2	0	0	4	4
RNA cytidine acetyltransferase	0	0	4	4
Serine/threonine-protein kinase SIK2	0	1	4	5
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	4	4
STE20-like serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO3	0	0	4	4
Homeodomain-interacting protein kinase 2	0	1	4	5
Tyrosine-protein kinase Srms	0	0	4	4
Homeodomain-interacting protein kinase 3	0	1	4	5
Serine/threonine-protein kinase PLK3	0	0	4	4
dCTP pyrophosphatase 1	0	0	4	4
Dual specificity protein kinase CLK4	0	0	4	4
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	4	4
Serine/threonine-protein kinase Nek6	0	0	4	4
Casein kinase I isoform gamma-1	0	0	4	4
Serine/threonine-protein kinase PAK 6	0	0	4	4
SNF-related serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase LATS2	0	0	4	4
Serine/threonine-protein kinase 36	0	0	4	4
Phenylalanine--tRNA ligase beta subunit	0	0	4	4
Isoleucine--tRNA ligase, mitochondrial	0	0	3	3
BMP-2-inducible protein kinase	0	0	4	4
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	4	4
Interleukin-1 receptor-associated kinase 4	0	0	4	4
Serine/threonine-protein kinase 32B	0	0	4	4
Mitogen-activated protein kinase kinase kinase 20	0	0	4	4
Cyclin-dependent kinase 12	0	0	4	4
Serine/threonine-protein kinase PLK2	0	0	4	4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	4	4
Serine/threonine-protein kinase MARK1	0	0	4	4
Serine/threonine-protein kinase pim-2	0	1	4	5
Serine/threonine-protein kinase PAK 5	0	0	4	4
Serine/threonine-protein kinase 26	0	0	4	4
eIF-2-alpha kinase GCN2	0	0	4	4
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	4	4
Serine/threonine-protein kinase NLK	0	0	4	4
Phosphatidylinositol 4-kinase beta	0	0	4	4
Serine/threonine-protein kinase 17A	0	0	4	4
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	4	4
Ephrin type-A receptor 6	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-2	0	0	4	4
Serine/threonine-protein kinase TBK1	0	0	4	4
Septin-9	0	0	4	4
Death-associated protein kinase 2	0	0	4	4
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Ribosomal protein S6 kinase alpha-6	0	0	4	4
TRAF2 and NCK-interacting protein kinase	0	0	4	4
Serine/threonine-protein kinase tousled-like 1	0	0	4	4
Serine/threonine-protein kinase TAO2	0	0	4	4
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
ALK tyrosine kinase receptor	0	1	4	5
SRSF protein kinase 3	0	0	4	4
Serine/threonine-protein kinase ICK	0	0	4	4
Cyclin-dependent kinase 11A	0	0	4	4
Aurora kinase C	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	1	4	5
Serine/threonine-protein kinase 38-like	0	0	4	4
Microtubule-associated serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase SIK3	0	1	4	5
Mitogen-activated protein kinase kinase kinase 2	0	0	4	4
Thyroid hormone receptor-associated protein 3	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 3	0	0	4	4
Serine/threonine-protein kinase MRCK beta	0	0	4	4
Interleukin-1 receptor-associated kinase 3	0	0	4	4
Serine/threonine-protein kinase 24	0	0	4	4
NF-kappa-B essential modulator	0	1	0	1
Casein kinase I isoform gamma-3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 4	0	0	4	4
Caspase-7	4	0	0	4
runt-related transcription factor 1 isoform AML1b	1	0	0	1
caspase-3	4	0	0	4
core-binding factor subunit beta isoform 2	1	0	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	1	2	9
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Multidrug resistance-associated protein 1	0	2	0	3
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	1	2
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Albumin	0	0	1	1
Luciferin 4-monooxygenase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	2
Nuclear factor NF-kappa-B p105 subunit	0	0	0	1
Tyrosine-protein phosphatase 1	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Vesicular glutamate transporter 3	0	1	0	1
nonstructural protein 1	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
5-hydroxytryptamine receptor 4	0	4	1	5
Fatty acid-binding protein, liver	0	3	2	5
Fatty acid-binding protein, liver	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M1	0	0	2	2
Muscarinic acetylcholine receptor M3	0	0	2	2
Muscarinic acetylcholine receptor M4	0	0	2	2
Muscarinic acetylcholine receptor M5	0	0	2	2
Adenosine receptor A3	0	6	0	6
Muscarinic acetylcholine receptor M2	0	0	2	2
Fatty acid-binding protein, intestinal	0	2	1	3
Beta-3 adrenergic receptor	0	2	0	2
Peroxisome proliferator-activated receptor alpha	0	1	3	4
Sodium-dependent noradrenaline transporter	0	2	1	3
Cruzipain	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
D(3) dopamine receptor	0	2	0	2
Peroxisome proliferator-activated receptor alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	5	4	10
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Peroxisome proliferator-activated receptor alpha	0	6	3	9
Sigma non-opioid intracellular receptor 1	0	0	2	2
Glutamate receptor ionotropic, NMDA 2D	0	0	2	2
Glutamate receptor ionotropic, NMDA 3B	0	0	2	2
Peroxisome proliferator-activated receptor delta	0	4	3	7
Glutamate receptor ionotropic, NMDA 1	0	0	2	2
Glutamate receptor ionotropic, NMDA 2A	0	0	2	2
Glutamate receptor ionotropic, NMDA 2B	0	0	2	2
Glutamate receptor ionotropic, NMDA 2C	0	0	2	2
Chloride channel isoform 1	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	0	2	2
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Bile salt export pump	0	3	0	3
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Cytochrome P450 2C8	0	0	0	1
Cytochrome P450 3A5	0	0	1	2
Cell division cycle 7-related protein kinase	0	0	2	2
Myosin-10	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	3	3
Oxysterols receptor LXR-beta	0	1	0	1
Tyrosine-protein kinase JAK2	0	0	1	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Heat shock protein HSP 90-alpha	0	3	3	6
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	0	1	1
Cyclin-A2	0	1	0	1
Nitric oxide synthase, brain	0	2	0	2
Cyclin-A1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Thromboxane A2 receptor	0	1	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	3
Squalene synthase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Platelet glycoprotein VI	0	1	2	4
Type-1 angiotensin II receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
Chain A, Beta-lactamase	4	0	0	4
hypothetical protein, conserved	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
tumor necrosis factor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	2	0	2
Muscarinic acetylcholine receptor M2	0	0	0	1
Muscarinic acetylcholine receptor M4	0	0	0	1
Muscarinic acetylcholine receptor M5	0	0	0	1
Muscarinic acetylcholine receptor M1	0	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Adenosine receptor A1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	3	0	3
Cytochrome P450 2J2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	1	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Receptor protein-tyrosine kinase	0	1	0	1
Rab-like protein 3	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	1	1
Fibroblast growth factor 1	0	0	1	1
Fibroblast growth factor 2	0	0	1	1
Vascular endothelial growth factor A	0	0	1	1
Heparanase	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Glucocorticoid receptor	0	6	2	13
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Aldo-keto reductase family 1 member B10	0	0	0	2
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Catechol O-methyltransferase	0	0	1	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Cannabinoid receptor 2	0	0	1	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
ATP-binding cassette sub-family C member 8	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Thrombin	0	0	1	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Serine/threonine-protein kinase ATR	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	1	1
Protein kinase C eta type	0	1	0	1
Serine/threonine-protein kinase 3	0	0	1	1
Protein kinase C theta type	0	1	0	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	0	1	0	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	0	1	0	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
vasopressin V1a receptor	0	0	1	1
oxytocin receptor	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
POsterior Segregation	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
1,25-dihydroxyvitamin D-3 receptor	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Vpr	1	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Corticotropin releasing hormone receptor 2	0	1	0	1
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4B	0	1	0	1
ATP-dependent molecular chaperone HSP82	0	1	0	1
Heat shock protein HSP 90-beta	0	2	2	6
Cholesteryl ester transfer protein	0	0	1	1
ATP-dependent molecular chaperone HSC82	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Endoplasmin	0	1	1	2
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
Heat-shock protein	0	1	0	1
Putative heat shock protein HSP 90-alpha A4	0	1	0	1
Lysine-specific demethylase 4C	0	1	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Vif	0	1	0	1
Tat	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (81)

Protein Targets (1,230)

Leukostasis

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (81)

Drugs Studied (98)

Protein Targets (1,230)