Compounds > benz(j)aceanthrylene
Page last updated: 2024-12-07

benz(j)aceanthrylene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Benz(j)aceanthrylene is a polycyclic aromatic hydrocarbon (PAH) that has been identified as a potent environmental mutagen and carcinogen. It is found in coal tar, diesel exhaust, and other combustion products. Benz(j)aceanthrylene is particularly carcinogenic in the skin and lungs. It has been shown to induce tumors in animals and is considered to be a significant human health risk. Benz(j)aceanthrylene is studied to understand its carcinogenic properties and to develop strategies for reducing human exposure to this compound. Synthesis of benz(j)aceanthrylene involves complex organic chemical reactions and is not commonly performed due to its carcinogenic nature.'

Cross-References

ID SourceID
PubMed CID104987
CHEMBL ID153437
CHEBI ID82290
MeSH IDM0113259

Synonyms (18)

Synonym
ccris 2269
naphth(2,1-d)acenaphthylene
benzo(7,8)aceanthrylene
benz(j)aceanthrylene
cholanthrylene
brn 4247917
CHEMBL153437
benzo[j]aceanthrylene
chebi:82290 ,
202-33-5
benz[j]aceanthrylene
C19195
unii-844qxh8pk1
844qxh8pk1 ,
benz(j)aceanthrylene [iarc]
AKOS025296229
DTXSID30174041
Q27155860

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The spectrum of activity of benz[j]aceanthrylene over the 5 Ames tester strains is similar to that of benzo[a]pyrene, and the dose-response curves for strain TA98 are comparable."( Benz[j]aceanthrylene: a novel polycyclic aromatic hydrocarbon with bacterial mutagenic activity.
Claxton, L; Easterling, R; Gold, A; Nesnow, S; Sangaiah, R; Toney, GE; Toney, SH, 1983)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenanthrenesAny benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID201033Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, with metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 5 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201030Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, with metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 1.0 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201035Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, without metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 1.0 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201034Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, without metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 0.5 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201037Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, without metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 20 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201036Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, without metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 10 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201031Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, with metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 10 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201038Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, without metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 5 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID200703Specific mutagenicity in the presence of protein S9, was expressed as His+ revertants/nmol, calculated by least-square linear regression.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201032Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, with metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 20 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID200702Specific mutagenicity in the absence of protein S9, was expressed as His+ revertants/nmol, calculated by least-square linear regression.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
AID201029Mutagenicity determined by Ames assay in Salmonella Typhimurium strain TA98, with metabolic activation by Aroclor 1254 induced rat liver S9 at a dose of 0.5 ug/plate1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Synthesis and biological activity of bay-region metabolites of a cyclopenta-fused polycyclic aromatic hydrocarbon: benz[j]aceanthrylene.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (27.78)18.7374
1990's13 (72.22)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.94 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.70 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (94.44%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenanthrene
phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'		1.9610ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes		environmental contaminant;
mouse metabolite
3-methylcholanthrene
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.		5.33180ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		4.3360ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		1.9710barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
1,2,5,6-dibenzanthracene
1,2,5,6-dibenzanthracene: RN given refers to parent cpd		3.0810ortho-fused polycyclic arenemutagen
benz(a)anthracene
benz(a)anthracene: 4 fused rings of which one is angular in contrast to the linear NAPHTHACENES. tetraphene : An angular ortho-fused polycyclic arene consisting of four fused benzene rings.		1.9610ortho-fused polycyclic arene;
tetraphenes
benzo(e)pyrene
benzo(e)pyrene: RN given refers to parent cpd. benzo[e]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.		1.9810ortho- and peri-fused polycyclic arenecarcinogenic agent;
mutagen
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		1.9910cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
cyclopenta(c,d)pyrene
cyclopenta(c,d)pyrene: structure		1.9810pyrenes
chlorodiphenyl (54% chlorine)
Chlorodiphenyl (54% Chlorine): A mixture of polychlorinated biphenyls that induces hepatic microsomal UDP-glucuronyl transferase activity towards thyroxine.. Aroclor 1254 : A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).		2.3820
benz(l)aceanthrylene
benz(l)aceanthrylene: structure given in first source		3.0850phenanthrenes
thioguanine anhydrous
Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.		1.96102-aminopurinesanticoronaviral agent;
antimetabolite;
antineoplastic agent
phosphorus radioisotopes
Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.		3.4920
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung
[description not available]		01.9810
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9810
Papilloma, Squamous Cell
[description not available]		01.9810
Cancer of Skin
[description not available]		01.9810
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)		01.9810
Skin Neoplasms
Tumors or cancer of the SKIN.		01.9810
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.6730