Page last updated: 2024-12-11

pimarane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pimarane: from Croton joufra; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Croton	genus	A plant genus of the family EUPHORBIACEAE. The common name of dragon's blood is also used for DRACAENA and Daemonorops (ARECACEAE). Croton tiglium is the source of CROTON OIL.[MeSH]	Euphorbiaceae	The spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]

Cross-References

ID Source	ID
PubMed CID	9548698
CHEBI ID	36547
MeSH ID	M0395958

Synonyms (4)

Synonym
pimarane
CHEBI:36547
(2r,4as,4br,8as,10as)-2-ethyl-2,4b,8,8-tetramethyl-3,4,4a,5,6,7,8a,9,10,10a-decahydro-1h-phenanthrene
Q27116878

Research Excerpts

Overview

Pimarane diterpenes are a structurally diverse family of natural products with various biological activities and pharmacological properties.

Excerpt	Reference	Relevance
"Pimarane diterpenes are a structurally diverse family of natural products with various biological activities and pharmacological properties."	( Bioactive Pimarane-Type Diterpenes from Marine Organisms. Liu, X; Lu, X; Wang, B; Wang, X; Yu, H; Zhang, Y, 2018)	1.6

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
terpenoid fundamental parent
diterpene	A C20 terpene.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (38)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	17 (44.74)	29.6817
2010's	20 (52.63)	24.3611
2020's	1 (2.63)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.46 (24.57)
Research Supply Index	3.66 (2.92)
Research Growth Index	4.54 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.46)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (7.89%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	35 (92.11%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chloroform Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.	2	1	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
abietic acid abietic acid : An abietane diterpenoid that is abieta-7,13-diene substituted by a carboxy group at position 18.	2.43	2	abietane diterpenoid; monocarboxylic acid	plant metabolite
totarol totarol: structure given in first source; isolated from the bark of Podocarpus nagi	2.04	1	diterpenoid	metabolite
ferruginol ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.	2.04	1	abietane diterpenoid; carbotricyclic compound; meroterpenoid; phenols	antibacterial agent; antineoplastic agent; plant metabolite; protective agent
abieta-7(8),13(14)-diene abieta-7(8),13(14)-diene: structure in first source. abietadiene : A diterpene consisting of abietane having two C=C double bonds at unspecified positions.	2.04	1	abietadiene
communic acid communic acid: structure in first source	2.04	1
glycosides [no description available]	2.02	1
labdane labdane: from Croton joufra; structure in first source	7	1	diterpene; terpenoid fundamental parent
acanthoic acid acanthoic acid: from root bark of Acanthopanax koreanum; structure given in first source	2.02	1
kirenol kirenol: an antirheumatic agent isolated from Siegebeckia; structure in first source	7.21	1	diterpenoid
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.01	1
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	2.01	1

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.1	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.1	1
Caries, Dental [description not available]	2.05	1
Dental Caries Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	2.05	1
Anasarca [description not available]	2.02	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.02	1
Leukemia L 1210 [description not available]	2.03	1

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