ailanthone profile

ailanthone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	102004514
MeSH ID	M0094887

Synonym
981-15-7
ailanthone

Excerpt	Reference	Relevance
" The validated method has been successfully applied to a pharmacokinetic study of ailanthone in rats."	( Development of a validated LC-MS/MS method for the determination of ailanthone in rat plasma with application to pharmacokinetic study. Chen, A; Liu, M; Lu, J; Qin, X; Wang, X; Yi, Z, 2015)	0.42

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (3.57)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (7.14)	29.6817
2010's	15 (53.57)	24.3611
2020's	10 (35.71)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.57%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (96.43%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pyridinolcarbamate Pyridinolcarbamate: A drug that has been given by mouth in the treatment of atherosclerosis and other vascular disorders, hyperlipidemias, and thrombo-embolic disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1408)	2.31	1	pyridines
quassin quassin: article discusses quassinoid principle; structure	1.96	1	triterpenoid
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	2.41	1	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
bruceine a bruceine A: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to (11 beta,12 alpha,15 beta)-isomer; structure given in first source	7.31	1	quassinoid
rhodamine 123 Rhodamine 123: A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30). rhodamine 123(1+) : A cationic fluorescent dye derived from 9-phenylxanthene.	2.17	1	organic cation; xanthene dye	fluorochrome
mdv 3100 [no description available]	2.54	2	(trifluoromethyl)benzenes; benzamides; imidazolidinone; monofluorobenzenes; nitrile; thiocarbonyl compound	androgen antagonist; antineoplastic agent
glaucarubin Glaucarubin: (1 beta,2 alpha,11 beta,12 alpha,15 beta(S))-11,20-Epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)picras-3-en-16-one. A quassinoid (Simaroubolide) from Simaruba glauca, a tropical shrub. It has been used as an antiamebic agent and is found to be cytotoxic. It may be of use in cancer chemotherapy.	1.96	1
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	1.96	1

Condition	Relationship Strength	Studies
Reproductive Sterility [description not available]	2.31	1
Infertility A reduced or absent capacity to reproduce.	7.31	1
Colorectal Cancer [description not available]	7.41	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.41	1
Malignant Melanoma [description not available]	3.33	4
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	3.33	4
Congenital Zika Syndrome [description not available]	2.6	1
African Swine Fever A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros).	2.6	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.6	1
Colitis Gravis [description not available]	2.6	1
Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	2.6	1
Bladder Cancer [description not available]	2.63	2
Cancer of Ovary [description not available]	2.25	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.63	2
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.25	1
Carcinoma, Non-Small Cell Lung [description not available]	3.51	2
Hepatocellular Carcinoma [description not available]	3.17	1
Cancer of Liver [description not available]	3.17	1
Cancer of Lung [description not available]	3.8	3
Androgen-Independent Prostatic Cancer [description not available]	4.01	4
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	3.51	2
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	3.17	1
Liver Neoplasms Tumors or cancer of the LIVER.	3.17	1
Lung Neoplasms Tumors or cancer of the LUNG.	3.8	3
Prostatic Neoplasms, Castration-Resistant Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.	4.01	4
Cancer of Stomach [description not available]	2.61	2
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.61	2
Acoustic Neuroma [description not available]	2.17	1
Breast Cancer [description not available]	7.21	1
Invasiveness, Neoplasm [description not available]	2.61	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.21	1
Acute Myelogenous Leukemia [description not available]	2.21	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.21	1
Metastase [description not available]	2.13	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.13	1
Cancer of Prostate [description not available]	2.15	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.15	1

ailanthone

Description

Cross-References

Synonyms (2)

Research Excerpts

Pharmacokinetics

Research

Studies (28)

Study Types

ailanthone

Description

Cross-References

Synonyms (2)

Research Excerpts

Pharmacokinetics

Research

Studies (28)

Study Types

Related Drugs (8)

Related Conditions (37)