Compounds > wilforlide a
Page last updated: 2024-11-07

wilforlide a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

wilforlide A: form Tripterygium regelii; Chinese medicinal plant extract [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
TripterygiumgenusA plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.[MeSH]CelastraceaeA plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID158477
CHEMBL ID484424
SCHEMBL ID2400908
MeSH IDM0150215

Synonyms (23)

Synonym
W0011
wilforlide a
3-epiabruslactone a
abruslactone a
CHEMBL484424
jw7qmp68bc ,
unii-jw7qmp68bc
olean-12-en-29-oic acid, 3,22-dihydroxy-, gamma-lactone, (3beta,20alpha,22alpha)-
S6428
AKOS025311465
CS-3763
SCHEMBL2400908
Q-100849
wilforlide-a
HY-N0476
regelide
mfcd00272168
(2s,5s,5ar,7as,7br,9ar,11s,13ar,13br,15bs)-11-hydroxy-2,5a,7a,7b,10,10,13a-heptamethyl-1,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,13b,14,15b-octadecahydro-2,5-methanochryseno[2,1-c]oxepin-3(2h)-one
(1s,2r,5s,6r,9r,11s,14r,15r,19s,21s)-11-hydroxy-2,5,6,10,10,14,21-heptamethyl-23-oxahexacyclo[19.2.1.02,19.05,18.06,15.09,14]tetracos-17-en-22-one
DTXSID601004388
3-hydroxy-22,29-epoxyolean-12-en-29-one
(-)-abruslactone a
olean-12-en-29-oic acid, 3,22-dihydroxy-, .gamma.-lactone, (3.beta.,20.alpha.,22.alpha.)-

Research Excerpts

Overview

Wilforlide A is a natural product that displays anti-inflammatory activities. It serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China.

ExcerptReferenceRelevance
"Wilforlide A is a natural product that displays anti-inflammatory activities."( Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.
Cao, Y; Chen, X; Huang, C; Huang, D; Liu, J; Tao, Y; Wang, Y, 2022)		2.89
"Wilforlide A (T(1)) serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China."( Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A.
Jiang, ZZ; Liu, JP; Liu, L; Wang, H; Wang, T; Xue, M; Zhang, LY; Zhou, ZX, 2010)		1.31

Actions

ExcerptReferenceRelevance
"Wilforlide A was found to enhance the chemosensitizing effect of docetaxel both in vitro and in vivo. "( Chemosensitizing Effect and Efficacy of Wilforlide A in Combination With Docetaxel in Drug-resistant Prostate Cancer.
Huang, Y; Sum Chow, MS; Wang, Z; Yang, S; Yeung, S, )		1.84
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID333605Induction of IL10 production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID1324617Antagonist activity at AR in human LNCAP cells assessed as suppression of DHT-induced receptor transcriptional activity at 5 uM after 24 hrs by dual luciferase reporter gene assay2016ACS medicinal chemistry letters, Dec-08, Volume: 7, Issue:12
Identification of Triptophenolide from
AID333599Induction of TNFalpha production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333602Induction of IFN-gamma production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333597Induction of IL12 production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333600Induction of TNFalpha production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333601Induction of IFN-gamma production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333596Induction of IL6 production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333604Induction of IL4 production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333603Induction of IL4 production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333598Induction of IL12 production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333595Induction of IL6 production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333606Induction of IL10 production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (8.33)18.7374
1990's1 (8.33)18.2507
2000's3 (25.00)29.6817
2010's5 (41.67)24.3611
2020's2 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.55

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.55 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.00 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.55)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bicalutamide
bicalutamide: approved for treatment of advanced prostate cancer. N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide : A member of the class of (trifluoromethyl)benzenes that is 4-amino-2-(trifluoromethyl)benzonitrile in which one of the amino hydrogens is substituted by a 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoyl group.. bicalutamide : A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.		2.1310(trifluoromethyl)benzenes;
monocarboxylic acid amide;
monofluorobenzenes;
nitrile;
sulfone;
tertiary alcohol
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.0510catechinantioxidant;
plant metabolite
oleanolic acid
[no description available]		4.7690hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
triptonide
triptonide: extracted from Tripterygium wilfordii; structure given in first source. triptonide : A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.		7.4720butenolide;
cyclic ketone;
diterpene triepoxide;
organic heteroheptacyclic compound		anti-inflammatory agent;
antineoplastic agent;
immunosuppressive agent
friedelin
3-friedelanone: from the stem bark of Irvingia gabonensis; structure in first source. friedelin : A pentacyclic triterpenoid that is perhydropicene which is substituted by an oxo group at position 3 and by methyl groups at the 4, 4a, 6b, 8a, 11, 11, 12b, and 14a-positions (the 4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS-enantiomer). It is the major triterpenoid constituent of cork.		2.0510cyclic terpene ketone;
pentacyclic triterpenoid		anti-inflammatory drug;
antipyretic;
non-narcotic analgesic;
plant metabolite
hydroxyflutamide
[no description available]		2.1310
triptolide
[no description available]		7.5220diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite
celastrol
[no description available]		2.1310monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite
triptophenolide
triptophenolide: structure given in first source		2.1310oxo steroid
4'-o-methylepigallocatechin
4'-methylepigallocatechin: antispasmodic from Maytenus rigida Mart (Celestraceae); structure in first source		2.0210catechinmetabolite
lupeol
[no description available]		2.0510pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite
glycosides
[no description available]		2.2510
mangiferin
shamimin: isolated from the leaves of Bombax ceiba; structure in first source		2.0510C-glycosyl compound;
xanthones		anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite
isoacteoside
isoacteoside: a phenylethanoid glycoside isolated from Indian paintbrush (Verbenaceae) Castilleja linariaefolia; also in other plants; structure given in first source		2.0210hydroxycinnamic acid
demethylzeylasteral
demethylzeylasteral: a phenolic nortriterpene; isolated from the root cortex of Tripterygium Wilfordii Hook f.. demethylzeylasteral : A carbopolycyclic compound with formula C29H36O6, originally isolated from Tripterygium wilfordii.		2.1310arenecarbaldehyde;
benzenediols;
carbopolycyclic compound;
cyclic ketone;
enone;
oxo monocarboxylic acid		anti-inflammatory agent;
EC 2.4.1.17 (glucuronosyltransferase) inhibitor;
immunosuppressive agent;
nephroprotective agent;
plant metabolite
mdv 3100
[no description available]		2.1310(trifluoromethyl)benzenes;
benzamides;
imidazolidinone;
monofluorobenzenes;
nitrile;
thiocarbonyl compound		androgen antagonist;
antineoplastic agent
sapogenins
Sapogenins: The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.		1.9710
triptotriterpenic acid a
triptotriterpenic acid A: from Tripterygium wilfordii; RN given refers to (3beta,22alpha)-isomer; structure given in first source. triptotriterpenic acid A : A pentacyclic triterpenoid with formula C30H48O4, originally isolated from Tripterygium hypoglaucum.		2.0210diol;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Exacerbation
[description not available]		02.4110
Rheumatoid Arthritis
[description not available]		07.4110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4110
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		02.4110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.7830
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Libman-Sacks Disease
[description not available]		02.0310
Dementia Praecox
[description not available]		02.0310
Lupus Erythematosus, Systemic
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.		02.0310
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.		02.0310