allyltrimethylsilane profile

Allyltrimethylsilane is a versatile reagent in organic synthesis, particularly for allylation reactions. It is a stable and commercially available compound, often used as a source of the allyl group (CH2=CHCH2-). Its importance lies in its ability to deliver the allyl group in a highly regio- and stereoselective manner, facilitating the construction of complex organic molecules. The compound is typically prepared via a hydrosilylation reaction, where allyl chloride reacts with trimethylsilane in the presence of a platinum catalyst. Allyltrimethylsilane's reactivity is attributed to the presence of the silicon atom, which is highly electropositive and can readily donate its electrons to the allyl group, making it a nucleophile. It participates in a variety of reactions, including carbon-carbon bond formation reactions, addition reactions, and ring-opening reactions. These reactions are often catalyzed by Lewis acids, such as boron trifluoride or titanium tetrachloride. Allyltrimethylsilane is extensively studied due to its wide application in organic synthesis, particularly in the synthesis of natural products, pharmaceuticals, and functional materials. It is also a useful tool for studying reaction mechanisms and developing new synthetic methodologies.'

allyltrimethylsilane: used to make allyl C-glycosylic compounds [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	69808
MeSH ID	M0407042

Synonym
LS-13228
AKOS008901411
silane, allyltrimethyl-
allyltrimethylsilane
762-72-1
allyl trimethylsilane
inchi=1/c6h14si/c1-5-6-7(2,3)4/h5h,1,6h2,2-4h
silane, trimethyl-2-propenyl-
allyl(trimethyl)silane
allyltrimethylsilane, 98%
einecs 212-104-5
ccris 2649
A0729
trimethyl(prop-2-enyl)silane
3-(trimethylsilyl)propene
silane, trimethyl-2-propen-1-yl-
unii-8b84c337vf
8b84c337vf ,
BP-20124
FT-0622058
allyltrimethyl silane
allyl-trimethyl-silane
allyl trimethyl silane
allyl-trimethylsilane
allyltrimethylsilane [mi]
trimethyl-2-propen-1-ylsilane
trimethyl(2-propenyl)silane
3-(trimethylsilyl)-1-propene
trimethylallylsilane
DTXSID5061089
ca0570
trimethyl-2-propenylsilane
Q-101307
mfcd00008635
J-802101
allyltrimethylsilane, 98+%
trimethyl(prop-2-en-1-yl)silane
Q2838752
AMY7007
EN300-52820

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (70.00)	29.6817
2010's	3 (30.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.21	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
phenanthrene phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'	2.21	1	ortho-fused polycyclic arene; ortho-fused tricyclic hydrocarbon; phenanthrenes	environmental contaminant; mouse metabolite
ether Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.	2.03	1	ether; volatile organic compound	inhalation anaesthetic; non-polar solvent; refrigerant
boranes Boranes: The collective name for the boron hydrides, which are analogous to the alkanes and silanes. Numerous boranes are known. Some have high calorific values and are used in high-energy fuels. (From Grant & Hackh's Chemical Dictionary, 5th ed). borane : The simplest borane, consisting of a single boron atom carrying three hydrogens.. boranes : The molecular hydrides of boron.	2.03	1	boranes; mononuclear parent hydride
boron trifluoride [no description available]	2.03	1	boron fluoride	NMR chemical shift reference compound
stannic chloride [no description available]	2.1	1
fluorine Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.	2.04	1	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
alkenes [no description available]	2.98	4
trimethylsilyl trifluoromethanesulfonate trimethylsilyl trifluoromethanesulfonate: deprotecting cpd for peptides	2.03	1
3,4,6-tri-o-acetylglucal 3,4,6-tri-O-acetylglucal: RN given refers to (D)-isomer with unspecified acetate locants	2	1
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	2	1
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.1	1
glycosides [no description available]	2.41	2
lithium tetrafluoroborate [no description available]	2	1
ciguatoxins Ciguatoxins: Polycyclic ethers produced by Gambierdiscus (DINOFLAGELLATES) from gambiertoxins, which are ingested by fish which in turn may be ingested by humans who are susceptible to the CIGUATERA POISONING.. ciguatoxin CTX1B : A ciguatoxin comprising a sequence of twelve trans-fused six-, seven-, eight- and nine-membered rings and a spiro-fused five-membered ring. A commonly encountered fish toxin.. ciguatoxin : Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by neurological, cardiovascular and gastrointestinal disorders.	2.04	1	ciguatoxin	metabolite
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.04	1	chalcogen; nonmetal atom	macronutrient
allylsilane allylsilane: structure in first source	2.1	1
oxepins Oxepins: Compounds based on a 7-membered heterocyclic ring including an oxygen. They can be considered a medium ring ether. A natural source is the MONTANOA plant genus. Some dibenzo-dioxepins, called depsidones, are found in GARCINIA plants.	2.04	1
ribose ribopyranose : The pyranose form of ribose.	2.03	1	D-ribose; ribopyranose
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	2.21	1

allyltrimethylsilane

Description

Cross-References

Synonyms (40)

Research

Studies (10)

Market Indicators

Research Demand Index: 33.00

Study Types