gigantol profile

gigantol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	3085362
CHEMBL ID	426871
SCHEMBL ID	16125315
MeSH ID	M0455109

Synonym
gigantol
CHEMBL426871
67884-30-4
5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol
SCHEMBL16125315
DTXSID90218112
AKOS028111718
phenol, 5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy-
3,3'-dihydroxy-5,4'-dimethoxybibenzyl
HY-N2523
CS-0022794
ZB1611
5-(3-hydroxy-5-methoxyphenethyl)-2-methoxyphenol
AMY23745
BCP29252
FT-0777246
EX-A2013
gigantol 1000 microg/ml in acetonitrile
5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol; 3,3'-dihydroxy-5,4'-dimethoxybibenzyl; gigantol
gigantol 100 microg/ml in acetonitrile
AC-34743
AS-76585
E87171

Excerpt	Reference	Relevance
"Gigantol is a phenolic compound extracted from Dendrobium."	( Effect of gigantol on the proliferation of hepatocellular carcinoma cells tested by a network-based pharmacological approach and experiments. Chen, X; Li, H; Li, J; Li, S; Li, X; Xue, X; Yi, Y; Yin, D, 2022)	1.85
"Gigantol is a phenolic component of precious Chinese medicine Dendrobii Caulis, which has many pharmacological activities such as prevent tumor and diabetic cataract. "	( [Mechanism of gigantol in transmembrane transport in human lens epithelial cells]. Hu, XH; Wei, XY, 2023)	2.71
"Gigantol is a pharmacologically active bibenzyl compound exerting potential anticancer activities. "	( Gigantol Targets MYC for Ubiquitin-proteasomal Degradation and Suppresses Lung Cancer Cell Growth. Chanvorachote, P; Losuwannarak, N; Roytrakul, S, )	3.02
"Gigantol is a bibenzyl compound isolated from orchids of the genus Dendrobium. "	( Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway. Du, H; Duan, S; Huang, C; Huang, J; Lin, J; Liu, C; Luo, Y; Tao, S; Wang, H; Wei, G; Xing, S; Zhang, X, 2021)	3.51
"Gigantol is a bibenzyl compound derived from several medicinal orchids. "	( Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. Li, S; Li, Y; Liu, S; Liu, ZJ; Lu, D; Song, J; Su, Z; Sun, Q; Wang, M; Wang, Z; Yu, S; Zhang, GQ; Zhang, X; Zhou, L, 2018)	3.37
"Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. "	( Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. Li, S; Li, Y; Liu, S; Liu, ZJ; Lu, D; Song, J; Su, Z; Sun, Q; Wang, M; Wang, Z; Yu, S; Zhang, GQ; Zhang, X; Zhou, L, 2018)	3.37
"Gigantol is a bibenzyl compound derived from several medicinal orchids. "	( Gigantol has Protective Effects against High Glucose-Evoked Nephrotoxicity in Mouse Glomerulus Mesangial Cells by Suppressing ROS/MAPK/NF-κB Signaling Pathways. Chen, MF; Hong, TY; Kao, ST; Liou, SS; Liu, IM, 2018)	3.37
"Gigantol (1) is a bibenzyl compound derived from the Thai orchid, Dendrobium draconis."	( Gigantol, a bibenzyl from Dendrobium draconis, inhibits the migratory behavior of non-small cell lung cancer cells. Chanvorachote, P; Charoenrungruang, S; Pongrakhananon, V; Sritularak, B, 2014)	2.57
"Gigantol is a typical bibenzyl compound isolated from Dendrobii Caulis that has been widely used as a medicinal herb in China for the treatment of diabetic cataract, cancer and arteriosclerosis obliterans and as a tonic for stomach nourishment, saliva secretion promotion and fever reduction. "	( Identification of the metabolites of gigantol in rat urine by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Fan, Y; Han, H; He, C; Wang, Z; Yang, L, 2014)	2.12
"Gigantol is a phenolic substance extracted from plants in the genus Dendrobium and used in traditional Chinese medicine. "	( Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway. Chen, H; Huang, J; Huang, Y; Lin, L; Wei, G, 2017)	3.34

Excerpt	Reference	Relevance
"Gigantol has been demonstrated to possess various pharmacologic (including anticancer) effects."	( Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway. Du, H; Duan, S; Huang, C; Huang, J; Lin, J; Liu, C; Luo, Y; Tao, S; Wang, H; Wei, G; Xing, S; Zhang, X, 2021)	2.79

Excerpt	Reference	Relevance
"Gigantol was found to inhibit lung cancer proliferation through induction of GSK3β-mediated MYC ubiquitin-proteasome degradation. "	( Gigantol Targets MYC for Ubiquitin-proteasomal Degradation and Suppresses Lung Cancer Cell Growth. Chanvorachote, P; Losuwannarak, N; Roytrakul, S, )	3.02
"Gigantol could inhibit proliferation of BC cells and enhance DDP-induced apoptosis. "	( Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway. Du, H; Duan, S; Huang, C; Huang, J; Lin, J; Liu, C; Luo, Y; Tao, S; Wang, H; Wei, G; Xing, S; Zhang, X, 2021)	3.51

Excerpt	Reference	Relevance
"To study the anti-cataract effect of gigantol combined with syringic acid and their action mechanism."	( [Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012)	0.93
"H202-induced lens oxidative injury in vitro rat model was establish to observe the impact of gigantol combined with syringic acid on lens transparency under a dissecting microscope."	( [Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012)	0.88
"Gigantol combined with syringic acid shows good anti-cataract, their action mechanism is reflected in their good collaborative inhibitory effect on AR."	( [Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012)	2.1

Assay ID	Title	Year	Journal	Article
AID1824692	Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID399549	Binding affinity to bovine brain calmodulin by electrophoretic mobility assay in presence of calcium chloride	2004	Journal of natural products, Feb, Volume: 67, Issue:2	Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii.
AID1432734	Cytoprotective activity against sodium taurocholate-induced necrosis in Balb/C mouse pancreatic acinar cells at 0.5 mM after 40 mins by propidium iodide/Hoechst 33342 staining-based fluorescence microscopic method	2017	Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6	Phenolic compounds isolated from Dioscorea zingiberensis protect against pancreatic acinar cells necrosis induced by sodium taurocholate.
AID399545	Spasmolytic activity in guinea pig ileum assessed as inhibition of spontaneous contraction	2004	Journal of natural products, Feb, Volume: 67, Issue:2	Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii.
AID269391	Spasmolytic activity in Wistar rat ileum	2006	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16	Design, microwave-assisted synthesis, and spasmolytic activity of 2-(alkyloxyaryl)-1H-benzimidazole derivatives as constrained stilbene bioisosteres.
AID1824689	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID399550	Inhibition of bovine brain CaM-dependent PDE assessed as inorganic phosphate release in presence of bovine brain calmodulin	2004	Journal of natural products, Feb, Volume: 67, Issue:2	Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii.
AID399546	Spasmolytic activity in guinea pig ileum assessed as inhibition of spontaneous contraction relative to papaverine	2004	Journal of natural products, Feb, Volume: 67, Issue:2	Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii.
AID1824731	Inhibition of pyruvate carboxylase in human HCCLM3 cell lysate measured upto 24 hrs by PC assay kit	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (22.22)	29.6817
2010's	18 (50.00)	24.3611
2020's	10 (27.78)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	38 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxybenzaldehyde [no description available]	2.13	1	hydroxybenzaldehyde	EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor; mouse metabolite; plant metabolite
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	2.04	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.03	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.5	2	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
guaiacol Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747). methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.. guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.	4.87	31	guaiacols	disinfectant; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; expectorant; plant metabolite
oxaloacetic acid Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.. oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.	2.41	1	C4-dicarboxylic acid; oxo dicarboxylic acid	geroprotector; metabolite
caffeine [no description available]	2.15	1	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic
chlorpromazine Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.	2.44	2	organochlorine compound; phenothiazines; tertiary amine	anticoronaviral agent; antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; phenothiazine antipsychotic drug
papaverine Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.	2.43	2	benzylisoquinoline alkaloid; dimethoxybenzene; isoquinolines	antispasmodic drug; vasodilator agent
trifluoperazine [no description available]	2.06	1	N-alkylpiperazine; N-methylpiperazine; organofluorine compound; phenothiazines	antiemetic; calmodulin antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; phenothiazine antipsychotic drug
tyramine [no description available]	2.13	1	monoamine molecular messenger; primary amino compound; tyramines	EC 3.1.1.8 (cholinesterase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	2.25	1	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2.41	1	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
propylparaben Parabens: Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)	2.04	1	benzoate ester; paraben; phenols	antifungal agent; antimicrobial agent
lithocholic acid Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.. lithocholic acid : A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.. lithocholate : A bile acid anion that is the conjugate base of lithocholic acid.	2.25	1	bile acid; C24-steroid; monohydroxy-5beta-cholanic acid	geroprotector; human metabolite; mouse metabolite
phloretic acid phloretic acid: structure. N-hydroxysuccinimide ester : An ester of N-hydroxysuccinimide.. phloretic acid : A hydroxy monocarboxylic acid consisting of propionic acid having a 4-hydroxyphenyl group at the 3-position.	2.13	1	hydroxy monocarboxylic acid	plant metabolite
syringic acid syringic acid: RN given refers to parent cpd; structure in third source. syringic acid : A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.	2.5	2	benzoic acids; dimethoxybenzene; phenols	plant metabolite
2-(2'-hydroxyphenyl)benzimidazole 2-(2'-hydroxyphenyl)benzimidazole: structure in first source	2.03	1
octyl gallate [no description available]	2.41	1	gallate ester	food antioxidant; hypoglycemic agent; plant metabolite
syringaresinol [no description available]	2.13	1	aromatic ether; furofuran; lignan; polyether; polyphenol	plant metabolite
3,3',4,5'-tetrahydroxybibenzyl 3,3',4,5'-tetrahydroxybibenzyl: from Cassia garrettiana; structure given in first source	2.02	1
cypripedin cypripedin: sensitizing agent for contact dermatitis from Lady Slipper (Cypripedium calceolus); structure	2.25	1	phenanthrol
dendrophenol dendrophenol: isolated from Dendrobium loddigesii	3.17	5
dihydroresveratrol dihydroresveratrol: structure in first source. dihydroresveratrol : A stilbenol that is 1,1'-ethane-1,2-diyldibenzene with hydroxy groups at positions 1, 3 and 4'.	2.02	1	stilbenol	plant metabolite; xenobiotic metabolite
erianin Erianin: from Dendrobium chrysotoxum; structure in first source	2.41	1
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.04	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
dihydropinosylvin dihydropinosylvin : A member of the class of resorcinols carrying an additional 2-phenylethyl substituent at position 5.	2.02	1	diphenylethane; resorcinols	EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
lusianthridin lusianthridin: from rhizome of Arundina graminifolia	2.02	1	dihydrophenanthrene
Hircinol [no description available]	2.41	1	phenanthrenes
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.53	2
gamma-sitosterol clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.	2.13	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols	marine metabolite; plant metabolite
rhapontin rhapontin: constituent of rhubarb rhizome	2.41	1	rhaponticin	angiogenesis inhibitor; anti-allergic agent; anti-inflammatory agent; antilipemic drug; antineoplastic agent; apoptosis inducer; EC 2.3.1.85 (fatty acid synthase) inhibitor; hypoglycemic agent; neuroprotective agent; plant metabolite
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	3.15	5	stilbene
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	2.48	2
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.25	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.03	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
feruloyltyramine feruloyltyramine: structure given in first source; isolated from Cannabis sativa seeds, roots, leaves, and resin; induces hypothermia and motor incoordination in mice; moupinamide is (E)-isomer	2.13	1	tyramines	metabolite
stigmasterol stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.	2.04	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols; stigmastane sterol	plant metabolite
chrysotoxine chrysotoxine: inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-κB modulation; structure in first source	2.25	1
n-cinnamoyltyramine N-cinnamoyltyramine: isolated from Lycianthes biflora; structure in first source. N-trans-cinnamoyltyramine : A member of the class of cinnamamides that is tyramine substituted by a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at the nitrogen atom. It is found in rice and exhibits an allelopathic effect to suppress the growth of weeds.	2.13	1	cinnamamides; phenols; secondary carboxamide	allelochemical; antimicrobial agent; phytoalexin; platelet aggregation inhibitor
3,7-dihydroxy-2,4-dimethoxyphenanthrene 3,7-dihydroxy-2,4-dimethoxyphenanthrene: from the orchid Scaphyglottis livida; structure in first source	2.03	1
batatasin-iii [no description available]	2.02	1	stilbenoid
cyclic diadenosine phosphate cyclic di-AMP : A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of AMP.	2.41	1	adenyl ribonucleotide; cyclic purine dinucleotide	Mycoplasma genitalium metabolite
lyoniside lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer	2.04	1
balanophonin balanophonin: from fruit wall of Cirsium vulgare; structure in first source	2.13	1
colistin Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.. colistin : A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.	7.6	1
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	3.03	4

Condition	Relationship Strength	Studies
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.02	1
Hepatocellular Carcinoma [description not available]	7.96	3
Cancer of Liver [description not available]	2.96	3
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.96	3
Liver Neoplasms Tumors or cancer of the LIVER.	2.96	3
Cataract, Membranous [description not available]	3.53	7
Cataract Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)	3.53	7
Acute Liver Injury, Drug-Induced [description not available]	2.25	1
Innate Inflammatory Response [description not available]	2.25	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.25	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.25	1
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.31	1
Benign Neoplasms, Brain [description not available]	2.31	1
Glial Cell Tumors [description not available]	2.31	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.31	1
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	2.31	1
Breast Cancer [description not available]	7.63	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.63	2
Diabetic Glomerulosclerosis [description not available]	2.17	1
Diabetic Nephropathies KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.	2.17	1
Carcinoma, Non-Small Cell Lung [description not available]	2.52	2
Cancer of Lung [description not available]	2.52	2
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.52	2
Lung Neoplasms Tumors or cancer of the LUNG.	2.52	2
Classic Galactosemia [description not available]	2.11	1
Galactosemias A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (PRIMARY OVARIAN INSUFFICIENCY); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)	2.11	1
Complications of Diabetes Mellitus [description not available]	2.82	3
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.13	1
Anasarca [description not available]	2.03	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.03	1

gigantol

Description

Cross-References

Synonyms (23)

Research Excerpts

Overview

Effects

Actions

Compound-Compound Interactions

Bioassays (9)

Research

Studies (36)

Market Indicators

Research Demand Index: 33.62

Study Types

gigantol

Description

Cross-References

Synonyms (23)

Research Excerpts

Overview

Effects

Actions

Compound-Compound Interactions

Bioassays (9)

Research

Studies (36)

Market Indicators

Research Demand Index: 33.62

Study Types

Related Drugs (47)

Related Conditions (30)