Compounds > octachlorostyrene
Page last updated: 2024-11-06

octachlorostyrene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Octachlorostyrene (OCS) is a highly chlorinated aromatic hydrocarbon that has been studied extensively due to its potential environmental and health effects. It is a persistent organic pollutant (POP) that can accumulate in the environment and bioaccumulate in food chains. OCS is typically produced as a byproduct of industrial processes, particularly the production of chlorinated solvents. It is also found in contaminated soil and water. OCS is known to be toxic to aquatic organisms and has been shown to cause developmental and reproductive problems in laboratory animals. Research on OCS focuses on its environmental fate and transport, its toxicity to various organisms, and its potential for bioremediation. The development of methods for the detection and removal of OCS from contaminated environments is also a major area of research.'
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Cross-References

ID SourceID
PubMed CID34466
CHEBI ID81542
SCHEMBL ID93255
MeSH IDM0062434

Synonyms (29)

Synonym
29082-74-4
1,2,3,4,5-pentachloro-6-(trichloroethenyl)benzene
octachlorostyrene
styrene, octachloro-
hsdb 6203
trichlorovinylpentachlorobenzene
benzene, pentachloro(trichloroethenyl)-
brn 2057011
ccris 5684
1,2,3,4,5-pentachloro-6-(1,2,2-trichloroethenyl)benzene
C18148
304368u4vh ,
unii-304368u4vh
62601-62-1
SCHEMBL93255
octachlorostyrene [hsdb]
CHEBI:81542
perchlorostyrene
RUYUCCQRWINUHE-UHFFFAOYSA-N
1,2,3,4,5-pentachloro-6-(1,2,2-trichlorovinyl)benzene #
DTXSID2021074
octachlorostyrene 100 microg/ml in cyclohexane
octachlorostyrene 10 microg/ml in cyclohexane
octachlorostyrene, vial of 1 g, analytical standard
1,2,3,4,5-pentachloro-6-(1,2,2-trichlorovinyl)benzene
Q27155456
3-amino-3-[5-(2,5-dichlorophenyl)-furan-2-yl]-propionicacidamide
octachlorostyrene 100 microg/ml in toluene
benzene, 1,2,3,4,5-pentachloro-6-(1,2,2-trichloroethenyl)-

Research Excerpts

Overview

Octachlorostyrene (OCS) is a persistent and bioaccumulative toxicant (PBT) that is a halogenated aromatic compound. It is present in fish of Northern European waters and the Great Lakes of America.

ExcerptReferenceRelevance
"Octachlorostyrene (OCS) is a ubiquitous persistent organic pollutant; however, information regarding the toxicological effects of OCS remains limited. "( Toxicity Assessment of Octachlorostyrene in Human Liver Carcinoma (HepG2) Cells.
An, J; Ren, G; Shang, Y; Wu, K; Yu, Z; Zheng, K, 2022)		2.47
"Octachlorostyrene (OCS) is a byproduct produced in the process of synthesis of chlorinated compounds. "( Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor.
Gonzalez, FJ; Ito, Y; Kamijima, M; Nakajima, T; Yanagiba, Y, 2009)		3.24
"Octachlorostyrene (OCS) is a persistent and bioaccumulative toxicant (PBT) that is a halogenated aromatic compound. "( Induction of oxidative stress in human Chang liver cells by octachlorostyrene, the persistent and bioaccumulative toxicant.
Park, EJ; Park, K, 2008)		2.03
"Octachlorostyrene (OCS) is an environmental contaminant, present in fish of Northern European waters and the Great Lakes of America. "( Influence of iron on the induction of hepatic tumors and porphyria by octachlorostyrene in C57BL/10ScSn mice.
Carthew, P; Francis, JE; Ingebrigtsen, K; Smith, AG, 1994)		1.97

Toxicity

ExcerptReferenceRelevance
"This study was designed to investigate the toxic effects produced by the long-term exposure to octachlorostyrene (OCS), a demonstrated environmental contaminant in the Great Lakes region of North America and the Norwegian Coast in Europe."( Long-term toxicity of octachlorostyrene in the rat.
Chu, I; Leeson, S; Secours, VE; Shen, SY; Valli, VE; Villeneuve, DC, 1986)		0.8
" These results indicate that OCS produced toxic effects at low levels of exposure and accumulated in the tissues of rats."( Octachlorostyrene: a 90-day toxicity study in the rat.
Chu, I; Reed, B; Secours, VE; Valli, VE; Villeneuve, DC; Yagminas, A, 1984)		1.71
"In recent years, microarray technology has enabled the investigation of possible mechanisms the expression of genes related to toxic compounds."( Whole genomic expression analysis of octachlorostyrene-induced chronic toxicity in Caenorhabditis elegans.
Choung, SY; Kim, SJ, 2009)		0.63
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (31)

TimeframeStudies, This Drug (%)All Drugs %
pre-199013 (41.94)18.7374
1990's3 (9.68)18.2507
2000's6 (19.35)29.6817
2010's7 (22.58)24.3611
2020's2 (6.45)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.43 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pentachlorophenol
PENTA: structure given in first source		1.9710aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes		human xenobiotic metabolite
phenanthrene
phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'		6.9610ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes		environmental contaminant;
mouse metabolite
dichlorodiphenyl dichloroethylene
Dichlorodiphenyl Dichloroethylene: An organochlorine pesticide, it is the ethylene metabolite of DDT.		2.0710chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
endosulfan
Endosulfan: A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61). endosulfan : A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.		7.1510cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
dichlorodiphenyldichloroethane
Dichlorodiphenyldichloroethane: An organochlorine insecticide that is slightly irritating to the skin. (From Merck Index, 11th ed, p482)		2.0710chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
rhodamine b
rhodamine B: RN & N1 from 9th CI Form Index; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7973; TETRAETHYLRHODAMINE was see RHODAMINES 1975-93; use RHODAMINES to search TETRAETHYLRHODAMINE 1975-93. rhodamine B : An organic chloride salt having N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium as the counterion. An amphoteric dye commonly used as a fluorochrome.		7.110organic chloride salt;
xanthene dye		fluorescent probe;
fluorochrome;
histological dye
hexachlorobenzene
Hexachlorobenzene: An agricultural fungicide and seed treatment agent.. hexachlorobenzene : A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.		3.68100aromatic fungicide;
chlorobenzenes		antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant
pentachlorobenzene
pentachlorobenzene: structure. pentachlorobenzene : A member of the class of pentachlorobenzenes that is benzene in which five of the hydrogens are replaced by chlorines. Now classed as a persistent organic pollutant under the Stockholm Convention.		2.0710pentachlorobenzenespersistent organic pollutant
cadmium sulfide
[no description available]		2.0810cadmium molecular entity
mirex
Mirex: An organochlorine insecticide that is carcinogenic.		2.0210chlorocarbon;
organochlorine insecticide		persistent organic pollutant
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		7.420elemental mercury;
zinc group element atom		neurotoxin
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.0810titanium group element atom
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.4920copper group element atom;
elemental gold
titanium dioxide
titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.		2.0810titanium oxidesfood colouring
delphinidin
Paraffin: A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.. delphinidin chloride : An anthocyanidin chloride that has delphinidin as the cationic counterpart.		2.1510anthocyanidin chloride
cadmium telluride
cadmium telluride: used in radiation monitoring device		2.4920
dieldrin
Dieldrin: An organochlorine insecticide whose use has been cancelled or suspended in the United States. It has been used to control locusts, tropical disease vectors, in termite control by direct soil injection, and non-food seed and plant treatment. (From HSDB). dieldrin : An organochlorine compound resulting from the epoxidation of the double bond of aldrin. It is the active metabolite of the proinsecticde aldrin.		2.0210epoxide;
organochlorine compound;
organochlorine insecticide		carcinogenic agent;
xenobiotic
aluminum
Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.		1.9910boron group element atom;
elemental aluminium;
metal atom
tellurium
Tellurium: An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.		2.4920chalcogen;
metalloid atom
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		02.4110
Cancer of Liver
[description not available]		02.4110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.4110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.4110
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.2510
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9610
Experimental Hepatoma
[description not available]		01.9810
Porphyria
[description not available]		02.3820
Porphyrias
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.		02.3820
Enlarged Liver
[description not available]		01.9610
Experimental Neoplasms
[description not available]		01.9610
Thyroid Diseases
Pathological processes involving the THYROID GLAND.		01.9610