Compounds > nitd008
Page last updated: 2024-11-13

nitd008

Description

NITD008: inhibits enterovirus 71 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44633776
CHEMBL ID1630221
SCHEMBL ID1736124
MeSH IDM000599952

Synonyms (24)

Synonym
(2r,3r,4r,5r)-2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-hydroxymethyl-tetrahydrofuran-3,4-diol
(2r,3r,4r,5r)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
nitd008
CHEMBL1630221 ,
NKRAIOQPSBRMOV-NRMKKVEVSA-N
SCHEMBL1736124
7-(2-c-ethynyl-?-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine
nitd 008
nitd-008
AKOS025396098
1044589-82-3
(2r,3r,4r,5r)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)oxolane-3,4-diol
7-(2-c-ethynyl-beta-d-ribofuranosyl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine
lki7t3wq2e ,
7h-pyrrolo(2,3-d)pyrimidin-4-amine, 7-(2-c-ethynyl-beta-d-ribofuranosyl)-
unii-lki7t3wq2e
HY-12957
CS-0012827
MS-24137
7h-pyrrolo(2,3-d)pyrimidin-4-amine, 7-(2-c-ethynyl-.beta.-d-ribofuranosyl)-
7-(2-c-ethynyl-.beta.-d-ribofuranosyl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine
bdbm50513993
DTXSID701159354
7-(2-c-ethynyl-beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine

Research Excerpts

Overview

NITD008 is an adenosine analogue inhibitor. It interrupts the RNA-dependent RNA polymerase of flaviviruses.

ExcerptReferenceRelevance
"NITD008 is an adenosine analogue inhibitor that interrupts the RNA-dependent RNA polymerase of flaviviruses."( Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection.
Nelson, J; Orillo, B; Roe, K; Shi, PY; Verma, S, 2015)		1.39

Toxicity

ExcerptReferenceRelevance
" Some have hypothesized that the active metabolites of toxic ribonucleoside analogs, the triphosphate forms, inadvertently target human mitochondrial RNA polymerase (POLRMT), thus inhibiting mitochondrial RNA transcription and protein synthesis."( Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs.
Behera, I; Beigelman, L; Chaudhuri, S; Deval, J; Dyatkina, N; Jekle, A; Jin, Z; Kinkade, A; Rajwanshi, VK; Smith, DB; Symons, JA; Tucker, K; Wang, G, 2017)		0.46

Dosage Studied

ExcerptRelevanceReference
" However, in vivo pharmacokinetic studies indicated that NITD449 had a low level of exposure in plasma when dosed orally."( Inhibition of dengue virus by an ester prodrug of an adenosine analog.
Chen, YL; Dartois, V; Duraiswamy, J; Goh, A; Keller, TH; Kondreddi, RR; Lakshminarayana, SB; Liu, B; Qing, M; Schul, W; Shi, PY; Weaver, M; Xu, HY; Yin, Z; Yip, A, 2010)		0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
NS5 Zika virusEC50 (µMol)0.13700.00870.54751.3000AID1558277; AID1558278; AID1558279; AID1558280
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (103)

Assay IDTitleYearJournalArticle
AID545704Antiviral activity against Dengue virus 2 TSVO1 infected in alpha/beta interferon and INFgamma receptor deficient AG129 mouse assessed as decrease in viral load treated 12 hrs postinfection measured after 3 days of infection by HPLC2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1813110Cytotoxicity against human RD cells assessed as reduction in cell viability by Cell Titer-Glo luminescent cell viability assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1813114Cmax in CD-1 mouse at 25 mg/kg, po by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID545702Drug uptake in rat blood assessed as di-derivatives of compound level at 25 mg/kg, po by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1338314Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay2016European journal of medicinal chemistry, Nov-29, Volume: 124Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.
AID1860888Selectivity index, ratio of CC50 for human RD cells to IC50 for CA6 infected in human RD cells2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1813105Half life in CD-1 mouse at 5 mg/kg, iv by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1860870Antiviral activity against ZIKV-SMGC-1 infected in human BHK cells incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID545677Cytotoxicity against human A549 cells assessed as intracellular ATP level by Celltiter-Glo luminescent assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1277368Antiviral activity against clinical isolates of Dengue virus 2 Martinique H/IMTSSA-MART/98-703 infected in African green monkey Vero E6 cells assessed as reduction in viral RNA after 4 days by qRT-PCR method2016European journal of medicinal chemistry, Feb-15, Volume: 109Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
AID1813113Cmax in CD-1 mouse at 5 mg/kg, iv by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1655476Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for Zika virus H/PF/2013 infected in human HuH7 cells2020ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.
AID545694Selectivity ratio of EC50 for Dengue virus 2 infected in human HEK293 cells in presence of siRNA targeting adenosine kinase to EC50 for Dengue virus 2 infected in human HEK293 cells in absence of siRNA targeting adenosine kinase2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1728710Antiviral activity against dengue virus 2 EDEN 3295 infected in human Huh-7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.
AID545705Antiviral activity against Dengue virus 2 TSVO1 infected in alpha/beta interferon and INFgamma receptor deficient AG129 mouse assessed as decrease in viral load at 150 mg/kg, po 12 hrs postinfection measured after 3 days of infection by HPLC2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1558283Cytotoxicity against African green monkey Vero cells2020Journal of medicinal chemistry, 01-23, Volume: 63, Issue:2
Drugs for the Treatment of Zika Virus Infection.
AID545698Drug uptake in rat blood assessed as di-derivatives of compound level at 5 mg/kg, ip by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1813117AUC ( 0 to infinity ) in CD-1 mouse at 5 mg/kg, iv by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1277371Antiviral activity against clinical isolates of Dengue virus 4 Martinique 017 infected in African green monkey Vero E6 cells assessed as reduction in viral RNA after 4 days by qRT-PCR method2016European journal of medicinal chemistry, Feb-15, Volume: 109Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
AID545680Cytotoxicity against hamster BHK21 cells assessed as intracellular ATP level upto 100 uM by Celltiter-Glo luminescent assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID545687Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral RNA synthesis at 3 uM after 35 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1813106Half life in CD-1 mouse at 25 mg/kg, po by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID545690Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral NS3 protein expression at 1 uM after 35 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1655472Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay2020ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.
AID1813109Selectivity index, ratio of CC50 for human RD cells to IC50 for Enterovirus A71 infected in human RD cells2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID545693Antiviral activity against Dengue virus 2 infected in human HEK293 cells assessed as level of viral titer after 48 hrs by luciferase reporter gene assay in presence of siRNA targeting adenosine kinase2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID545686Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral RNA synthesis at 1 uM after 35 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1860877Antiviral activity against EV71 infected in human RD cells incubated for 3 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1860880Cytotoxicity against human RD cells infected with EV71 incubated for 3 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1860874Antiviral activity against YFV-17D infected in human BHK cells incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1813116AUC ( 0 to last) in CD-1 mouse at 25 mg/kg, po by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1860878Antiviral activity against CA6 infected in human RD cells incubated for 3 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1860889Selectivity index, ratio of CC50 for human RD cells to IC50 for CA16 infected in human RD cells2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1860872Cytotoxicity against human BHK cells infected with DENV-NGC-1 incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1813111Antiviral activity against Enterovirus A71 infected in human RD cells assessed as inhibition of viral replication measured after 4 days by Cell Titer-Glo luminescent cell viability assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID545689Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral NS3 protein expression at 3 uM after 24 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1813108Antiviral activity against Enterovirus D68 infected in human RD cells assessed as inhibition of viral replication measured after 4 days by Cell Titer-Glo luminescent cell viability assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID545700Drug uptake in rat plasma at 25 mg/kg, po by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID545682Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral RNA synthesis at 1 uM after 2 to 4 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1277370Antiviral activity against clinical isolates of Dengue virus 4 Dakar HD34460 infected in African green monkey Vero E6 cells assessed as reduction in viral RNA after 4 days by qRT-PCR method2016European journal of medicinal chemistry, Feb-15, Volume: 109Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
AID1813115AUC ( 0 to last) in CD-1 mouse at 5 mg/kg, iv by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID545703Drug uptake in rat blood assessed as tri-derivatives of compound level at 25 mg/kg, po by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1206538Antiviral activity against dengue virus 2 TSV01 in AG129 mouse model of dengue viremia assessed as log reduction in virus plaques at 25 mg/kg, po BID for 3 days relative to untreated control2015ACS medicinal chemistry letters, Mar-12, Volume: 6, Issue:3
Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.
AID1558280Inhibition of RNA-dependent RNA polymerase in Zika virus FSS13025/2010 infected in African green monkey Vero cells assessed as antiviral activity by measuring viral RNA by RT-qPCR method2020Journal of medicinal chemistry, 01-23, Volume: 63, Issue:2
Drugs for the Treatment of Zika Virus Infection.
AID1813118AUC ( 0 to infinity ) in CD-1 mouse at 25 mg/kg, po by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1655473Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay2020ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.
AID1860885Selectivity index, ratio of CC50 for human BHK cells to IC50 for JEV-SA14 infected in human BHK cells2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1338298Antiviral activity against EV71 assessed as reduction in viral replication after 72 hrs by CellTiter-glo luminescent cell viability assay2016European journal of medicinal chemistry, Nov-29, Volume: 124Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.
AID1813104Tmax in CD-1 mouse at 5 mg/kg, iv by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1860884Selectivity index, ratio of CC50 for human BHK cells to IC50 for DENV-NGC infected in human BHK cells2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1860882Cytotoxicity against human RD cells infected with CA16 incubated for 3 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID546797Antiviral activity against Dengue virus 4 MY22713 infected in human A549 cells by CFI assay2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
AID1860879Antiviral activity against CA16 infected in human RD cells incubated for 3 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID545692Antiviral activity against Dengue virus 2 infected in human A549 cells assessed as level of E protein production up to 20 uM by ELISA in presence of 0.2 uM adenosine kinase inhibitor iodotubercidin2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1558279Inhibition of RNA-dependent RNA polymerase in Zika virus GZ01/2016 infected in African green monkey Vero cells assessed as antiviral activity by measuring viral RNA by RT-qPCR method2020Journal of medicinal chemistry, 01-23, Volume: 63, Issue:2
Drugs for the Treatment of Zika Virus Infection.
AID1728709Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 48 hrs by celltiter glo luminescent assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.
AID546793Antiviral activity against Dengue virus 2 NGC infected in human A549 cells by CFI assay2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
AID1860869Antiviral activity against DENV-NGC-1 infected in human BHK cells incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID546798Antiviral activity against Dengue virus 2 NGC infected in human PBMC cells by plaque assay2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
AID1655475Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay2020ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.
AID545701Drug uptake in rat blood assessed as mono-derivatives of compound level at 25 mg/kg, po by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1860875Cytotoxicity against human BHK cells infected with JEV-SA14 incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID545676Antiviral activity against at 0.3 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as reduction in viral titer after 48 hrs postinfection2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1860881Cytotoxicity against human RD cells infected with CA6 incubated for 3 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID545688Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral NS3 protein expression at 1 uM after 24 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1277369Antiviral activity against clinical isolates of Dengue virus 3 Bolivia 4025 infected in African green monkey Vero E6 cells assessed as reduction in viral RNA after 4 days by qRT-PCR method2016European journal of medicinal chemistry, Feb-15, Volume: 109Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
AID1813107Selectivity index, ratio of CC50 for human RD cells to IC50 for Enterovirus D68 infected in human RD cells2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID545679Antiviral activity against at 0.3 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as reduction in viral titer at 6 uM after 48 hrs postinfection2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID545706Antiviral activity against Dengue virus 2 TSVO1 infected in alpha/beta interferon and INFgamma receptor deficient AG129 mouse assessed as decrease in viral load at 300 mg/kg, po 12 hrs postinfection measured after 3 days of infection by HPLC2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1728714Selectivity index, ratio of CC50 for human Huh-7 cells to EC50 for dengue virus 2 EDEN 3295 infected in human Huh-7 cells2021European journal of medicinal chemistry, Jan-15, Volume: 210Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.
AID1277367Antiviral activity against clinical isolates of Dengue virus 1 Indonesia JKT 1186 TVP 949 infected in African green monkey Vero E6 cells assessed as reduction in viral RNA after 4 days by qRT-PCR method2016European journal of medicinal chemistry, Feb-15, Volume: 109Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
AID1338313Antiviral activity against EV71 infected in African green monkey Vero cells after 48 hrs by plaque assay2016European journal of medicinal chemistry, Nov-29, Volume: 124Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.
AID1860871Cytotoxicity against human BHK cells infected with ZIKV-SMGC-1 incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID545678Antiviral activity against at 0.3 MOI Dengue virus 2 infected in human A549 cells assessed as level of E protein after 48 hrs by ELISA2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1860887Selectivity index, ratio of CC50 for human RD cells to IC50 for EV71 infected in human RD cells2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID546795Antiviral activity against Dengue virus 2 MY10340 infected in human A549 cells by CFI assay2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
AID1277366Antiviral activity against clinical isolates of Dengue virus 2 Trinidad 1751 TC 544 infected in African green monkey Vero E6 cells assessed as reduction in viral RNA after 4 days by qRT-PCR method2016European journal of medicinal chemistry, Feb-15, Volume: 109Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
AID545685Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral RNA synthesis at 3 uM after 24 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1860876Cytotoxicity against human BHK cells infected with YFV-17D incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID545707Antiviral activity against 3x10'7 PFU Dengue virus 2 D2S10 infected in alpha/beta interferon and INFgamma receptor deficient AG129 mouse assessed as protection against lethal virus challenge at 75 mg/kg, po treated 12 hrs postinfection by HPLC2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID547042Antiviral activity against Dengue virus 2 TSV01 infected in AG129 mouse assessed as reduced viremia by 25 mg/kg, po BID for 3 days measured on day 4 by plaque assay2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
AID1277365Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability treated for 3 days measured on day 4 by cell titer-blue fluorescent assay2016European journal of medicinal chemistry, Feb-15, Volume: 109Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
AID545697Drug uptake in rat blood assessed as mono-derivatives of compound level at 5 mg/kg, ip by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1699914Antiviral activity against DENV-2 infected in African green monkey Vero cells assessed as virus titer reduction incubated for 48 hrs by plaque assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro.
AID545683Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral RNA synthesis at 3 uM after 2 to 4 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1558278Inhibition of RNA-dependent RNA polymerase in Zika virus FSS13025/2010 infected in African green monkey Vero cells assessed as antiviral activity measured 48 hrs post infection by plaque assay2020Journal of medicinal chemistry, 01-23, Volume: 63, Issue:2
Drugs for the Treatment of Zika Virus Infection.
AID1728715Selectivity index, ratio of CC50 for human Huh-7 cells to EC50 for Zika virus H/PF/2013 infected in human Huh-7 cells2021European journal of medicinal chemistry, Jan-15, Volume: 210Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.
AID1655474Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for Dengue virus 2 EDEN 3295 infected in human HuH7 cells2020ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.
AID545684Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral RNA synthesis at 1 uM after 24 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1860883Selectivity index, ratio of CC50 for human BHK cells to IC50 for ZIKV-SMGC-1 infected in human BHK cells2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID546796Antiviral activity against Dengue virus 3 MY22366 infected in human A549 cells by CFI assay2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
AID545699Drug uptake in rat blood assessed as tri-derivatives of compound level at 5 mg/kg, ip by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID545691Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as decrease in viral NS3 protein expression at 3 uM after 35 hrs post-transfection by luciferase reporter gene assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID545695Antiviral activity against Dengue virus 2 infected in human HEK293 cells assessed as level of viral titer after 48 hrs by luciferase reporter gene assay in presence of siRNA targeting deoxycytidine kinase2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID1728712Antiviral activity against Zika virus H/PF/2013 infected in human Huh-7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.
AID1813112Tmax in CD-1 mouse at 25 mg/kg, po by LC-MS/MS2021European journal of medicinal chemistry, Dec-15, Volume: 226Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.
AID1558277Inhibition of RNA-dependent RNA polymerase in Zika virus GZ01/2016 infected in African green monkey Vero cells assessed as antiviral activity measured 48 hrs post infection by plaque assay2020Journal of medicinal chemistry, 01-23, Volume: 63, Issue:2
Drugs for the Treatment of Zika Virus Infection.
AID1860873Antiviral activity against JEV-SA14 infected in human BHK cells incubated for 7 days by CellTiter 96 luminescent cell viability assay2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1860886Selectivity index, ratio of CC50 for human BHK cells to IC50 for YFV-17D infected in human BHK cells2022European journal of medicinal chemistry, Aug-05, Volume: 238Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
AID1700577Antiviral activity against Zika virus Z16019 infected in human A549 cells assessed as reduction in viral titer preincubated for 1 hr followed by compound washout and subsequent compound addition without virus and measured after 48 hrs by plaque assay
AID545681Antiviral activity against at 1 MOI of Dengue virus 2 infected in hamster BHK21 cells assessed as viral titer after 48 hrs postinfection by plaque assay2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID545696Drug uptake in rat plasma at 5 mg/kg, ip by fast protein liquid chromatography2010Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
AID546794Antiviral activity against Dengue virus 1 MY10245 infected in human A549 cells by CFI assay2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's17 (70.83)24.3611
2020's7 (29.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.06 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.64 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.06)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinacrine
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.		3.3510acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
triphosphoric acid
triphosphoric acid: used as water softener, peptizing agent, emulsifier & dispersing agent; ingredient of cleansers; meat preservative; RN given refers to parent cpd; structure		2.1710acyclic phosphorus acid anhydride;
phosphorus oxoacid
amodiaquine
Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.. amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.		3.3510aminoquinoline;
organochlorine compound;
phenols;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
drug allergen;
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor;
non-steroidal anti-inflammatory drug;
prodrug
berberine
[no description available]		3.3510alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound		antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		3.3510aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
emodin
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.		3.3510trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
vorinostat
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).		7.1110dicarboxylic acid diamide;
hydroxamic acid		antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.110amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
cytidine
[no description available]		2.1510cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tubercidin
Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.		3.3510antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite
valine
Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.		2.110L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		2.110isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		2.1510diazine;
pyrazines		Daphnia magna metabolite
emetine
Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.		3.3510isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor
bromocriptine
Bromocriptine: A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.		3.3510indole alkaloidantidyskinesia agent;
antiparkinson drug;
dopamine agonist;
hormone antagonist
ribavirin
Rebetron: Rebetron is tradename		3.68201-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
mefloquine
(-)-(11S,2'R)-erythro-mefloquine : An optically active form of [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol having (-)-(11S,2'R)-erythro-configuration. An antimalarial agent, used in racemic form, which acts as a blood schizonticide; its mechanism of action is unknown.		3.3510[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanolantimalarial
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		4.1130adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		3.3510flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
sinefungin
[no description available]		3.7620adenosines;
non-proteinogenic alpha-amino acid		antifungal agent;
antimicrobial agent
pinocembrin
pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.		3.3510(2S)-flavan-4-one;
dihydroxyflavanone		antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent
epicatechin gallate
epicatechin gallate: a steroid 5alpha-reductase inhibitor; RN given refers to the (cis)-isomer; structure given in first source; isolated from green tea. (-)-epicatechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.		3.3510catechin;
gallate ester;
polyphenol		EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
methotrexate
[no description available]		3.3510dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
vx 497
N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester: structure in first source		3.3510
(-)-gallocatechin gallate
(-)-gallocatechin gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-gallocatechin. A natural product found in found in green tea.		3.3510catechin;
gallate ester;
polyphenol		antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human xenobiotic metabolite;
plant metabolite
4'-azidocytidine
4'-azidocytidine: antiviral; structure in first source		2.1510N-glycosyl compound
favipiravir
favipiravir : A member of the class of pyrazines that is pyrazine substituted by aminocarbonyl, hydroxy and fluoro groups at positions 2, 3 and 6, respectively. It is an anti-viral agent that inhibits RNA-dependent RNA polymerase of several RNA viruses and is approved for the treatment of influenza in Japan.		2.1510hydroxypyrazine;
organofluorine compound;
primary carboxamide		anticoronaviral agent;
antiviral drug;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
2'-c-methyladenosine
2'-C-methyladenosine: antiviral		2.0510
benzoic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-3-pyrazolyl] ester
[no description available]		3.3510benzoate ester
telaprevir
[no description available]		2.1310cyclopentapyrrole;
cyclopropanes;
oligopeptide;
pyrazines		antiviral drug;
hepatitis C protease inhibitor;
peptidomimetic
luteolin
[no description available]		3.35103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
luteolin-7-glucoside
luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum. luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.		2.1310beta-D-glucoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		antioxidant;
plant metabolite
rutin
Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.		3.6820disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
chrysin
chrysin : A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.		2.13107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
fisetin
[no description available]		2.13103'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
hinokiflavone
hinokiflavone: from Rhus succedanea; structure given in first source. hinokiflavone : A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic potential.		2.1310aromatic ether;
biflavonoid;
hydroxyflavone		antineoplastic agent;
metabolite;
neuroprotective agent
myricetin
[no description available]		3.35107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
astragalin
kaempferol-3-O-glucoside: isolated from the pit of Mahkota dewa; structure in first source. kaempferol 3-O-beta-D-glucoside : A kaempferol O-glucoside in which a glucosyl residue is attached at position 3 of kaempferol via a beta-glycosidic linkage.		3.3510beta-D-glucoside;
kaempferol O-glucoside;
monosaccharide derivative;
trihydroxyflavone		plant metabolite;
trypanocidal drug
rupintrivir
rupintrivir: a rhinovirus 3C protease inhibitor		2.5220
gsk 369796
N-tert-butylisoquine: an antimalarial; structure in first source		3.3510
galidesivir
[no description available]		3.3510
balapiravir
balapiravir: a prodrug of R1479; structure in first source		2.1510
sofosbuvir
Sofosbuvir: A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.. sofosbuvir : A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.		3.9630isopropyl ester;
L-alanyl ester;
nucleotide conjugate;
organofluorine compound;
phosphoramidate ester		antiviral drug;
hepatitis C protease inhibitor;
prodrug
bms-986094
BMS-986094: a prodrug of 2'-C-methylguanosine and antiviral agent		2.1510
novobiocin
Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.		3.3510carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent
guanosine monophosphate
Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.		2.1510guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Break-Bone Fever
[description not available]		02.4920
Dengue
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.		02.4920
Congenital Zika Syndrome
[description not available]		04.0740
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		04.0740
Enterovirus Infections
Diseases caused by ENTEROVIRUS.		02.930
Enterically-Transmitted Non-A, Non-B Hepatitis
[description not available]		02.2110
Hepatitis E
Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.		02.2110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2110
Microcephaly
A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)		02.2110
Abnormalities, Congenital, Nervous System
[description not available]		02.2110
Complications, Infectious Pregnancy
[description not available]		02.2110
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.2110
Caliciviridae Infections
Virus diseases caused by CALICIVIRIDAE. They include HEPATITIS E; VESICULAR EXANTHEMA OF SWINE; acute respiratory infections in felines, rabbit hemorrhagic disease, and some cases of gastroenteritis in humans.		02.2110
Encephalitis, West Nile Fever
[description not available]		02.1110
West Nile Fever
A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)		02.1110
Chronic Hepatitis C
[description not available]		02.1310
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
[description not available]		02.1310
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.		07.1310
Hepatitis C, Chronic
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.		02.1310
Infections, Tick-Borne
[description not available]		02.1310
Flavivirus Infections
Infections with viruses of the genus FLAVIVIRUS, family FLAVIVIRIDAE.		02.1310
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