Page last updated: 2024-12-05

4-bromoacetophenone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-Bromoacetophenone is a solid organic compound with the formula C8H7BrO. It is a brominated derivative of acetophenone. This compound is a useful building block in organic synthesis and has been used to synthesize a variety of compounds, including pharmaceuticals, pesticides, and dyes. It is also used as a reagent in the synthesis of other organic compounds. The synthesis of 4-bromoacetophenone typically involves the bromination of acetophenone using bromine in the presence of a Lewis acid catalyst. The reaction is typically carried out in an inert solvent, such as dichloromethane or chloroform. 4-Bromoacetophenone is a versatile starting material for the synthesis of other organic compounds. It can be used to prepare a variety of derivatives, including amines, ketones, and aldehydes. The compound has also been used in the synthesis of pharmaceuticals, pesticides, and dyes. Research on 4-bromoacetophenone has been focused on its applications in organic synthesis and its potential medicinal properties. The compound has been investigated for its activity against various diseases, including cancer and bacterial infections.'

Cross-References

ID SourceID
PubMed CID7466
CHEMBL ID401928
SCHEMBL ID20102
MeSH IDM0073769

Synonyms (72)

Synonym
BIDD:ER0705
AC-3632
1-(4-bromophenyl)-ethanone
nsc17541
99-90-1
methyl p-bromophenyl ketone
ethanone, 1-(4-bromophenyl)-
4'-bromoacetophenone
acetophenone, 4'-bromo-
p-bromophenyl methyl ketone
p-bromoacetophenone
nsc-17541
1-(4-bromophenyl)ethanone
inchi=1/c8h7bro/c1-6(10)7-2-4-8(9)5-3-7/h2-5h,1h
acetophenone,4-bromo
STK358825
1-(4-bromo-phenyl)-ethanone
4'-bromoacetophenone, 98%
B0537
CHEMBL401928
4-bromoacetophenone
FT-0663620
AKOS000119010
A19693
1-(4-bromophenyl)ethanone; 1-acetyl-4-bromobenzene; p-bromoacetophenone;4'-bromoacetophenone
1-acetyl-4-bromobenzene
1-(4-bromophenyl)ethan-1-one
7nb3xry0c6 ,
nsc 17541
einecs 202-799-3
ai3-00489
unii-7nb3xry0c6
FT-0617848
PS-3069
AM20050031
4-bromobenzene methyl ketone
4-acetylbromobenzene
4-bromohypnone
1-(p-bromophenyl)ethanone
methyl 4-bromophenyl ketone
4-acetylphenyl bromide
4-bromophenyl methyl ketone
acetophenone, p-bromo-
4-acetyl-1-bromobenzene
1-bromo-4-acetylbenzene
p-bromoacetophenone [mi]
SCHEMBL20102
J-501375
4-bromophenylethanone
4'-bromo acetophenone
1-(4-bromo-phenyl)ethan-1-one
4-bromo acetophenone
DTXSID4059203
F3096-1713
W-100010
STR00836
4 inverted exclamation mark -bromoacetophenone
CS-W020546
4'-bromoacetophenone-d7
1219805-88-5
1-(4-bromophenyl)ethanone #
mfcd00000105
Z57127459
SY001458
ethanone,1-(4-bromophenyl)-
EN300-17995
OL10143
AC7918
para-bromoacetophenone
Q27268608
PB47185
HY-20436
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID1101839Phytotoxicity against Lactuca sativa (lettuce) assessed as inhibition of seed germination after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101821Phytotoxicity against Lactuca sativa (lettuce) assessed as inhibition of seed germination at 500 uM after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID323693Activity of rat liver 3-alpha-HSD assessed as formation of corresponding (S)-alcohol products per mg of protein2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.
AID1101815Phytotoxicity against Lactuca sativa (lettuce) assessed as inhibition of seed respiration during germination after 24 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101836Phytotoxicity against Lolium multiflorum (Italian ryegrass) assessed as inhibition of shoot development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101803Antioxidant activity assessed as DPPH free radical scavenging activity after 30 min by TLC autographic assay2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101816Phytotoxicity against Lolium multiflorum (Italian ryegrass) assessed as inhibition of seed respiration during germination after 24 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101810Phytotoxicity against Trifolium pratense (red clover) assessed as inhibition of seed respiration during germination after 24 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101834Phytotoxicity against Lactuca sativa (lettuce) assessed as inhibition of shoot development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID323692Ratio of Vmax to Km for rat liver 3-alpha-HSD for formation of corresponding (S)-alcohol products2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.
AID1101828Phytotoxicity against Lactuca sativa (lettuce) assessed as inhibition of seed germination at > 500 uM after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101829Phytotoxicity against Trifolium pratense (red clover) assessed as inhibition of root development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101837Phytotoxicity against Trifolium pratense (red clover) assessed as inhibition of seed germination after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101824Increase of shoot development during seeding stage in Physalis ixocarpa up to 50 uM after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101833Phytotoxicity against Lactuca sativa (lettuce) assessed as inhibition of root development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101832Phytotoxicity against Physalis ixocarpa assessed as inhibition of shoot development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101825Increase of root development during seeding stage in Trifolium pratense (red clover) at 50 to 300 uM after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID323691Activity of rat liver 3-alpha-HSD assessed as formation of corresponding (S)-alcohol products2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.
AID1101830Phytotoxicity against Trifolium pratense (red clover) assessed as inhibition of shoot development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101806Inhibition of H+ uptake in Spinacia oleracea (spinach) chloroplasts2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1656234Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay2019European journal of medicinal chemistry, Feb-15, Volume: 164Green recipes to quinoline: A review.
AID1101831Phytotoxicity against Physalis ixocarpa assessed as inhibition of root development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101838Phytotoxicity against Physalis ixocarpa assessed as inhibition of seed germination after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101840Phytotoxicity against Lolium multiflorum (Italian ryegrass) assessed as inhibition of seed germination after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101826Increase of root development during seeding stage in Lactuca sativa (lettuce) at 50 to 300 uM after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101827Phytotoxicity against Lolium multiflorum (Italian ryegrass) assessed as inhibition of seed germination at > 500 uM after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101812Phytotoxicity against Physalis ixocarpa assessed as inhibition of seed respiration during germination after 24 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101822Phytotoxicity against Lolium multiflorum (Italian ryegrass) assessed as inhibition of seed germination at 500 uM after 48 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101823Increase of shoot development during seeding stage in Trifolium pratense (red clover) at 200 uM after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
AID1101835Phytotoxicity against Lolium multiflorum (Italian ryegrass) assessed as inhibition of root development during seeding stage after 120 hr2002Journal of agricultural and food chemistry, Apr-10, Volume: 50, Issue:8
Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 46.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index46.76 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index67.31 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (46.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]