Page last updated: 2024-12-08

methaneboronic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID139377
CHEMBL ID257679
MeSH IDM0300528

Synonyms (44)

Synonym
8z1me41sch ,
unii-8z1me41sch
dihydroxymethylborane
inchi=1/ch5bo2/c1-2(3)4/h3-4h,1h
methylboronic acid, 97%
methaneboronic acid
methylboronic acid
M1553
13061-96-6
methane boronic acid
CHEMBL257679
NCGC00249444-01
bdbm39818
methylboronicacid
ch5bo2
AKOS005174709
FT-0600796
ch3b(oh)2
methyboronic acid
methyl-boronic acid
KTMKRRPZPWUYKK-UHFFFAOYSA-N
meb(oh)2
methyl boronic acid
methylboronic acid [ii]
boronic acid, methyl-
STR07997
Q-101086
116234-45-8
DTXSID20156639
mfcd00002105
BBL101819
SY001105
CS-W018525
STL555616
2-methylhydrogenpyridine-2,5-dicarboxylate
BCP10976
SB11771
boronic acid, methyl- (9ci)
Q27271221
A888694
methylboronic acid 98%
boronicacid, methyl-
EN300-40252
HY-34449
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Beta-lactamaseStaphylococcus aureusKi1,750.00007.30007.30007.3000AID1799471
Beta-lactamaseEscherichia coli K-12Ki1,750.00000.02703.64137.3000AID1799471
Calcium release-activated calcium channel protein 1Homo sapiens (human)IC50 (µMol)500.00000.50004.25009.8000AID749402; AID749403
Protein orai-2Homo sapiens (human)IC50 (µMol)500.00008.70009.25009.8000AID749402; AID749403
Protein orai-3Homo sapiens (human)IC50 (µMol)500.00004.00007.50009.8000AID749402; AID749403
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (14)

Processvia Protein(s)Taxonomy
antibiotic catabolic processBeta-lactamaseEscherichia coli K-12
response to antibioticBeta-lactamaseEscherichia coli K-12
store-operated calcium entryCalcium release-activated calcium channel protein 1Homo sapiens (human)
adaptive immune responseCalcium release-activated calcium channel protein 1Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayCalcium release-activated calcium channel protein 1Homo sapiens (human)
positive regulation of insulin secretionCalcium release-activated calcium channel protein 1Homo sapiens (human)
positive regulation of adenylate cyclase activityCalcium release-activated calcium channel protein 1Homo sapiens (human)
regulation of calcium ion transportCalcium release-activated calcium channel protein 1Homo sapiens (human)
positive regulation of calcium ion transportCalcium release-activated calcium channel protein 1Homo sapiens (human)
mammary gland epithelium developmentCalcium release-activated calcium channel protein 1Homo sapiens (human)
calcium ion importCalcium release-activated calcium channel protein 1Homo sapiens (human)
calcium ion transmembrane transportCalcium release-activated calcium channel protein 1Homo sapiens (human)
ion channel modulating, G protein-coupled receptor signaling pathwayCalcium release-activated calcium channel protein 1Homo sapiens (human)
ligand-gated ion channel signaling pathwayCalcium release-activated calcium channel protein 1Homo sapiens (human)
store-operated calcium entryProtein orai-2Homo sapiens (human)
calcium ion transmembrane transportProtein orai-2Homo sapiens (human)
store-operated calcium entryProtein orai-3Homo sapiens (human)
calcium ion transmembrane transportProtein orai-3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
beta-lactamase activityBeta-lactamaseEscherichia coli K-12
hydrolase activityBeta-lactamaseEscherichia coli K-12
calcium channel activityCalcium release-activated calcium channel protein 1Homo sapiens (human)
protein bindingCalcium release-activated calcium channel protein 1Homo sapiens (human)
calmodulin bindingCalcium release-activated calcium channel protein 1Homo sapiens (human)
store-operated calcium channel activityCalcium release-activated calcium channel protein 1Homo sapiens (human)
identical protein bindingCalcium release-activated calcium channel protein 1Homo sapiens (human)
protein bindingProtein orai-2Homo sapiens (human)
store-operated calcium channel activityProtein orai-2Homo sapiens (human)
protein bindingProtein orai-3Homo sapiens (human)
store-operated calcium channel activityProtein orai-3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (9)

Processvia Protein(s)Taxonomy
outer membrane-bounded periplasmic spaceBeta-lactamaseEscherichia coli K-12
periplasmic spaceBeta-lactamaseEscherichia coli K-12
plasma membraneCalcium release-activated calcium channel protein 1Homo sapiens (human)
membraneCalcium release-activated calcium channel protein 1Homo sapiens (human)
basolateral plasma membraneCalcium release-activated calcium channel protein 1Homo sapiens (human)
plasma membrane raftCalcium release-activated calcium channel protein 1Homo sapiens (human)
membrane raftCalcium release-activated calcium channel protein 1Homo sapiens (human)
calcium channel complexCalcium release-activated calcium channel protein 1Homo sapiens (human)
membraneCalcium release-activated calcium channel protein 1Homo sapiens (human)
plasma membraneProtein orai-2Homo sapiens (human)
growth coneProtein orai-2Homo sapiens (human)
membraneProtein orai-2Homo sapiens (human)
plasma membraneProtein orai-3Homo sapiens (human)
membraneProtein orai-3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID749401Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx up to 500 uM after 5 mins by FLIPR assay2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport.
AID749400Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx up to 500 uM after 5 mins by FLIPR assay2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport.
AID749402Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport.
AID749403Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport.
AID315582Inhibition of AmpC beta lactamase2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors.
AID1799471Enzyme Inhibition Assay from Article 10.1016/S1074-5521(00)00052-1: \\Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.\\2001Chemistry & biology, Jan, Volume: 8, Issue:1
Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's7 (53.85)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.59 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.23 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]