Target type: molecularfunction
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. [EC:3.1.2.22]
Palmitoyl-(protein) hydrolase activity, also known as palmitoyl protein thioesterase activity, refers to the enzymatic hydrolysis of a thioester bond between a palmitoyl group and a protein. This specific type of hydrolase cleaves the fatty acid palmitate from the cysteine residue of a protein, removing a palmitoyl group. Palmitoylation is a reversible post-translational modification that involves the attachment of palmitate, a 16-carbon saturated fatty acid, to cysteine residues of proteins. This modification plays a crucial role in regulating protein localization, stability, and interaction with other proteins. Palmitoyl-(protein) hydrolase activity is essential for maintaining cellular homeostasis by controlling the level of palmitoylated proteins and influencing various cellular processes, including signal transduction, protein trafficking, and membrane organization.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Acyl-protein thioesterase 2 | An acyl-protein thioesterase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95372] | Homo sapiens (human) |
| Lysophosphatidylserine lipase ABHD12 | A lysophosphatidylserine lipase ABHD12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N2K0] | Homo sapiens (human) |
| Acyl-protein thioesterase 2 | An acyl-protein thioesterase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95372] | Homo sapiens (human) |
| Acyl-protein thioesterase 1 | An acyl-protein thioesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75608] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| benzo(b)thiophene-2-boronic acid | benzo(b)thiophene-2-boronic acid: inhibits AmpC beta-lactamase; structure in first source | ||
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | 1,6-bis(cyclohexyloximinocarbonyl)hexane: selective inhibitor of canine platelet diglyceride lipase | carbamate ester; organonitrogen compound | |
| dronabinol | Delta(9)-tetrahydrocannabinol : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy. Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. | benzochromene; diterpenoid; phytocannabinoid; polyketide | cannabinoid receptor agonist; epitope; hallucinogen; metabolite; non-narcotic analgesic |
| benzeneboronic acid | boronic acids | ||
| 1,1'-biphenyl-4-yl-boronic acid | |||
| orlistat | orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity. | beta-lactone; carboxylic ester; formamides; L-leucine derivative | anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor |
| palmostatin b | palmostatin B: inhibits acyl protein thioesterase 1; structure in first source | ||
| palmostatin m | palmostatin M: inhibits acyl protein thioesterases 1 and 2; structure in first source |