Target type: molecularfunction
Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN]
Alkylglycerophosphoethanolamine phosphodiesterase activity is a hydrolytic enzymatic activity that catalyzes the cleavage of the phosphodiester bond in alkylglycerophosphoethanolamine (also known as plasmalogen). This reaction results in the formation of lysophosphatidylcholine and an alkyl alcohol. Alkylglycerophosphoethanolamine phosphodiesterase is an important enzyme in the metabolism of plasmalogens, a class of phospholipids that are essential for maintaining cell membrane integrity and function. Plasmalogens are particularly abundant in the brain and heart, where they play crucial roles in signal transduction, membrane fluidity, and protection against oxidative stress. Alkylglycerophosphoethanolamine phosphodiesterase activity is also involved in the degradation of plasmalogens that have been damaged by oxidation or other forms of stress. This process helps to remove potentially harmful oxidized lipids from the cell membrane. The enzyme is found in various tissues, including the brain, heart, liver, and kidneys, and is highly regulated by factors such as hormones, nutrient availability, and cellular stress levels. Deficiencies in alkylglycerophosphoethanolamine phosphodiesterase activity have been linked to several diseases, including neurodegenerative disorders, cardiovascular disease, and cancer. In addition, the enzyme has been implicated in the pathogenesis of inflammatory diseases and autoimmune disorders. Understanding the molecular function of alkylglycerophosphoethanolamine phosphodiesterase is crucial for developing new therapeutic strategies for treating these diseases. The development of specific inhibitors of the enzyme could be useful for treating disorders characterized by excessive plasmalogen accumulation, while the development of activators of the enzyme could be beneficial for treating diseases associated with plasmalogen deficiency.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13822] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| evans blue | Evans blue : An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppress background autofluorescence. Evans Blue: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly. | organic sodium salt | fluorochrome; histological dye; sodium channel blocker; teratogenic agent |
| congo red | Congo Red : An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0. Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS. | bis(azo) compound | |
| benzeneboronic acid | boronic acids | ||
| 3-aminobenzeneboronic acid | |||
| dioctanoylphosphatidic acid | dioctanoylphosphatidic acid: structure given in first source | 1,2-diacyl-sn-glycerol 3-phosphate; octanoate ester | |
| 4-methoxyphenylboronic acid | 4-methoxyphenylboronic acid: structure in first source | ||
| lysophosphatidic acid | 1-oleoyl-sn-glycerol 3-phosphate : A 1-acyl-sn-glycerol 3-phosphate having oleoyl as the 1-O-acyl group. lysophosphatidic acid : A member of the class of lysophosphatidic acids obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid. A 'closed' class. lysophosphatidic acid: RN given refers to parent cpd | 1-acyl-sn-glycerol 3-phosphate | |
| ubistatin a | ubistatin A: inhibits cyclin B proteolysis and degradation of ubiquitinated Sic1; structure in first source | ||
| ursodoxicoltaurine | tauroursodeoxycholate : An organosulfonate oxoanion that is the conjugate base of tauroursodeoxycholic acid arising from deprotonation of the sulfonate OH group; major species at pH 7.3. tauroursodeoxycholic acid : A bile acid taurine conjugate derived from ursoodeoxycholic acid. | bile acid taurine conjugate | anti-inflammatory agent; apoptosis inhibitor; bone density conservation agent; cardioprotective agent; human metabolite; neuroprotective agent |
| pf 8380 | |||
| ono-8430506 | ONO-8430506: an autotaxin inhibitor; structure in first source |