| Assay ID | Title | Year | Journal | Article |
|---|
| AID1460768 | Inhibition of human CA5A by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID437817 | Inhibition of Actinomadura sp. R39 penicillin-binding protein assessed as residual activity at 1000 uM preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitrobenzoic ac | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID437825 | Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X assessed as residual activity at 1000 uM preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitroben | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID1863503 | Inhibition of C-terminal His tagged SARS CoV-2 main protease transfected in Escherichia coli BL21 (DE3) using 2-Abz-Ser-AlaVal-Leu-Gln-Ser-Gly-Tyr(3-NO2)-Arg-OH as substrate at 50 uM preincubated for 15 mins followed by substrate addition and measured aft | | | |
| AID1575852 | Inhibition of Mycobacterium tuberculosis H37Rv leuRS | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8
| Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. |
| AID266925 | Antifungal activity against Trichophyton rubrum | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. |
| AID1569288 | Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14
| Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents. |
| AID664801 | Binding affinity to adenosine monophosphate in phosphate buffer by ARS competition assay at pH 7.4 | 2012 | ACS medicinal chemistry letters, Jan-12, Volume: 3, Issue:1
| Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore. |
| AID1460773 | Inhibition of human CA12 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1863502 | Inhibition of C-terminal His tagged SARS CoV-2 main protease transfected in Escherichia coli BL21 (DE3) using 2-Abz-Ser-AlaVal-Leu-Gln-Ser-Gly-Tyr(3-NO2)-Arg-OH as substrate preincubated for 15 mins followed by substrate addition and measured after 15 min | | | |
| AID1863518 | Inhibition of trypsin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate assessed as enzymatic cleavage at 50 uM preincubated for 15 mins followed by substrate addition and measured after 15 mins by continuous fluorimetric assay | | | |
| AID1460764 | Inhibition of human CA1 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1460775 | Inhibition of human CA14 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1726061 | Inhibition of Vibrio cholerae gamma carbonic anhydrase incubated for 30 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | | | |
| AID1569290 | Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14
| Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents. |
| AID1726065 | Selectivity index, ratio of Ki for human carbonic anhydrase 2 to Ki for Vibrio cholerae gamma carbonic anhydrase | | | |
| AID1594610 | Drug reactivity against serine in PBS buffer by NMR assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10
| Characterising covalent warhead reactivity. |
| AID266929 | Antifungal activity against Aspergillus fumigatus | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. |
| AID1460776 | Inhibition of mouse CA15 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID588171 | Inhibition of Trypanosoma brucei TREU927 Leucyl-tRNA Synthetase expressed in Escherichia coli BL21 (DE3)-RIPL using [14C]Leu by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5
| Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents. |
| AID1863527 | Inhibition of WNV NS2B-NS3 protease using 2-Abz-Gly-Lys-Lys-Arg-Gly-Tyr(3-NO2)-Ala-Lys-NH2 as substrate at 50 uM preincubated for 15 mins followed by substrate addition and measured after 15 mins by FRET assay | | | |
| AID266928 | Antifungal activity against Cryptococcus neoformans | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. |
| AID1863520 | Cytotoxicity against human HeLa cells expressing renilla luciferase reporter construct assessed as reduction in cell viability at 12.5 uM by luciferase based analysis | | | |
| AID1726059 | Inhibition of Vibrio cholerae alpha carbonic anhydrase incubated for 30 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | | | |
| AID1569291 | Cytotoxicity against human WI38 cells after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14
| Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents. |
| AID1460771 | Inhibition of human CA7 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1460769 | Inhibition of human CA5B by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1863505 | Inhibition of full length DENV2 NS2B-NS3 protease in human HeLa cells expressing luciferase reporter gene at 12.5 uM incubated for 24 hrs by luminescence analysis relative to control | | | |
| AID1594614 | Reversible drug reactivity against serine in PBS buffer by NMR assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10
| Characterising covalent warhead reactivity. |
| AID1863526 | Inhibition of full length DENV2 NS2B-NS3 protease using 2-Abz-Nle-Lys-Arg-Arg-Ser-Tyr(3-NO2)-NH2 as substrate at 50 uM preincubated for 15 mins followed by substrate addition and measured after 15 mins by FRET assay | | | |
| AID1460770 | Inhibition of human CA6 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID664800 | Dissociation constant, pKa of the compound in aqueous solution by [11]B-NMR analysis | 2012 | ACS medicinal chemistry letters, Jan-12, Volume: 3, Issue:1
| Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore. |
| AID664799 | Dissociation constant, pKa of the compound in aqueous solution by spectrophotometry | 2012 | ACS medicinal chemistry letters, Jan-12, Volume: 3, Issue:1
| Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore. |
| AID1594613 | Reversible drug reactivity against cysteine in PBS buffer by NMR assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10
| Characterising covalent warhead reactivity. |
| AID1504706 | Inhibition of Malassezia globosa beta-carbonic anhydrase incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11
| Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study. |
| AID1460765 | Inhibition of human CA2 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1460772 | Inhibition of human CA9 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1863506 | Cytotoxicity against human HeLa cells expressing luciferase-based DENV-2 protease reporter system assessed as reduction in cell viability by celltiter-blue assay | | | |
| AID1460767 | Inhibition of human CA4 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1460766 | Inhibition of human CA3 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1504709 | Inhibition of human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11
| Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study. |
| AID1726064 | Selectivity index, ratio of Ki for human carbonic anhydrase 2 to Ki for Vibrio cholerae beta carbonic anhydrase | | | |
| AID1504710 | Inhibition of human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11
| Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study. |
| AID1460774 | Inhibition of human CA13 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19
| Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1504708 | Inhibition of Candida glabrata Nce103 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11
| Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study. |
| AID1504707 | Inhibition of Cryptococcus neoformans Can2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11
| Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study. |
| AID1569289 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14
| Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents. |
| AID1863504 | Inhibition of full length DENV2 NS2B-NS3 protease in human HeLa cells expressing luciferase reporter gene incubated for 24 hrs by luminescence analysis | | | |
| AID266927 | Antifungal activity against Candida albicans | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. |
| AID266926 | Antifungal activity against Trichophyton mentagrophytes | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. |
| AID437828 | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X assessed as residual activity at 1000 uM preincubated for 4 hrs before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitroben | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID1726060 | Inhibition of Vibrio cholerae beta carbonic anhydrase incubated for 30 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | | | |
| AID437822 | Inhibition of Actinomadura sp. R39 penicillin-binding protein at 1 mM preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitrobenzoic acid) | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID1863519 | Inhibition of thrombin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate assessed as enzymatic cleavage at 50 uM preincubated for 15 mins followed by substrate addition and measured after 15 mins by continuous fluorimetric assay | | | |
| AID1726063 | Selectivity index, ratio of Ki for human carbonic anhydrase 2 to Ki for Vibrio cholerae alpha carbonic anhydrase | | | |
| AID1594609 | Drug reactivity against cysteine in PBS buffer by NMR assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10
| Characterising covalent warhead reactivity. |
| AID1726062 | Inhibition of human carbonic anhydrase 2 incubated for 30 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | | | |
| AID1575851 | Antitubercular activity against Mycobacterium tuberculosis H37Rv by time-kill assay | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8
| Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |