Target type: molecularfunction
Catalysis of the hydrolysis of a lipid or phospholipid. [GOC:mah, ISBN:0198506732]
Lipase activity refers to the enzymatic hydrolysis of ester bonds in triglycerides, which are the main constituents of fats and oils. This process involves the breakdown of triglycerides into glycerol and free fatty acids. Lipases are crucial for the digestion and absorption of dietary fats, playing a vital role in energy metabolism. They catalyze the reaction by binding to the triglyceride substrate and facilitating the addition of a water molecule across the ester bond. This results in the cleavage of the bond and the release of fatty acids and glycerol. The activity of lipases can be influenced by various factors such as pH, temperature, and the presence of inhibitors. Lipases are found in a wide range of organisms, including animals, plants, and microorganisms, and they have diverse applications in various industries, including food processing, pharmaceuticals, and bioremediation.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Diacylglycerol lipase-beta | A diacylglycerol lipase-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NCG7] | Homo sapiens (human) |
| Lysosomal acid lipase/cholesteryl ester hydrolase | A lysosomal acid lipase/cholesteryl ester hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P38571] | Homo sapiens (human) |
| Arylacetamide deacetylase | An arylacetamide deacetylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22760] | Homo sapiens (human) |
| Pancreatic triacylglycerol lipase | A pancreatic triacylglycerol lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16233] | Homo sapiens (human) |
| Acyl-protein thioesterase 1 | An acyl-protein thioesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75608] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| benzo(b)thiophene-2-boronic acid | benzo(b)thiophene-2-boronic acid: inhibits AmpC beta-lactamase; structure in first source | ||
| flutamide | Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species. | (trifluoromethyl)benzenes; monocarboxylic acid amide | androgen antagonist; antineoplastic agent |
| phenacetin | Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione | acetamides; aromatic ether | cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug |
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | 1,6-bis(cyclohexyloximinocarbonyl)hexane: selective inhibitor of canine platelet diglyceride lipase | carbamate ester; organonitrogen compound | |
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| benzeneboronic acid | boronic acids | ||
| Koenimbine | koenimbin: has antineoplastic activity; isolated from curry leaf, Murraya koenigii; structure in first source | carbazoles | |
| 1,1'-biphenyl-4-yl-boronic acid | |||
| mahanimbine | mahanimbine: from Murraya koenigii leaves; structure in first source | carbazoles | |
| carnosol | carnosol: isolated from Lepechinia hastata | diterpenoid | |
| orlistat | orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity. | beta-lactone; carboxylic ester; formamides; L-leucine derivative | anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor |
| t-tucb | |||
| osteum | organic molecular entity | ||
| palmostatin b | palmostatin B: inhibits acyl protein thioesterase 1; structure in first source | ||
| lalistat 2 | |||
| palmostatin m | palmostatin M: inhibits acyl protein thioesterases 1 and 2; structure in first source | ||
| rifampin | Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) | cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion | angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor |