Compounds > 2,5-dihydroxy-1,4-benzoquinone
Page last updated: 2024-11-06

2,5-dihydroxy-1,4-benzoquinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,5-dihydroxy-1,4-benzoquinone, also known as juglone, is a naturally occurring quinone found in plants like walnut trees. It exhibits a wide range of biological activities, including antimicrobial, antifungal, and antioxidant properties. Its synthesis can be achieved through various methods, including oxidation of hydroquinone or enzymatic conversion of juglone precursors. It is studied for its potential applications in medicine, agriculture, and environmental remediation. Its antimicrobial properties make it a promising candidate for developing new antibiotics, while its antioxidant activity offers potential benefits in protecting against oxidative stress-related diseases. Moreover, its ability to inhibit plant growth suggests potential uses as a natural herbicide. '

2,5-dihydroxy-1,4-benzoquinone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID69213
SCHEMBL ID169616
MeSH IDM0368405

Synonyms (52)

Synonym
BIDD:ER0578
2,5-dihydroxy-[1,4]benzoquinone
615-94-1
2,4-dione, 2,5-dihydroxy-
p-benzoquinone,5-dihydroxy-
2,5-dihydroxy-p-benzoquinone
nsc3843
nsc-3843
p-benzoquinone, 2,5-dihydroxy-
2,5-cyclohexadiene-1,4-dione, 2,5-dihydroxy-
p-benzoquinone, 2,5-dihydroxy
2,5-dihydroxy-1,4-benzoquinone
2,5-dhbqop
1760-52-7
nsc144259
nsc-144259
2,5-dihydroxy-1,4-benzoquinone, 98%
D0574
2,5-dihydroxy-p-quinone
STK802466
2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
AKOS000121182
BBL011605
nsc 3843
0kg5hvb52z ,
unii-0kg5hvb52z
einecs 210-454-3
ai3-23193
FT-0610378
4LBP
SCHEMBL169616
2,5-dihydroxy benzoquinone
DTXSID4060658
2,5-dihyroxy-p-benzoquinone
2,5-dihydroxybenzoquinone
2,5-dihydroxybenzo-1,4-quinone #
J-200143
mfcd00001598
AS-65333
CS-W011039
Q4596784
SY048323
2,5-dihydroxy-2,5-cyclohexadiene-1,4-dione
anilic acid
quinone, 2,5-dihydroxy-
4,5-dihydroxycyclohexa-3,5-diene-1,2-dione
DTXSID60938739
2,5-cyclohexadiene-1,4-dione,2,5-dihydroxy-
A855200
YSWG206
4,5-dihydroxy-1,2-benzoquinone
EN300-28248
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2013The Journal of biological chemistry, Oct-04, Volume: 288, Issue:40
Catalytic mechanism of 5-chlorohydroxyhydroquinone dehydrochlorinase from the YCII superfamily of largely unknown function.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.18 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.69 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formaldehyde
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy		2.1710aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
pentachlorophenol
PENTA: structure given in first source		2.0210aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes		human xenobiotic metabolite
quinone
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.. 1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.. quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).		2101,4-benzoquinonescofactor;
human xenobiotic metabolite;
mouse metabolite
tetrahydroxy-1,4-quinone
tetrahydroxy-1,4-quinone: structure. tetrahydroxy-1,4-benzoquinone : A hydroxybenzoquinone in which all four protons of the benzoquinone structure are substituted by hydroxy groups. A systemic keratolytic, it is normally supplied as its hydrate (CHEBI:137471).		210hydroxybenzoquinonekeratolytic drug
bromobenzene
[no description available]		2.1710bromoarene;
bromobenzenes;
volatile organic compound		hepatotoxic agent;
mouse metabolite;
non-polar solvent
chlorobenzene
[no description available]		2.1710monochlorobenzenessolvent
fluorobenzenes
Fluorobenzenes: Derivatives of BENZENE that contain FLUORINE.. monofluorobenzene : The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.. fluorobenzenes : Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.		2.1710monofluorobenzenesNMR chemical shift reference compound
triphenylphosphine
triphenylphosphine: RN given refers to parent cpd. triphenylphosphine : A member of the class of tertiary phosphines that is phosphane in which the three hydrogens are replaced by phenyl groups.		2.1710benzenes;
tertiary phosphine		NMR chemical shift reference compound;
reducing agent
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.1710metal allergen;
nickel group element atom;
platinum group metal atom
benzeneboronic acid
[no description available]		2.1710boronic acids
1,2,4,5-tetrahydroxybenzene
1,2,4,5-tetrahydroxybenzene: structure in first source		710
2-hydroxy-1,4-benzoquinone
2-hydroxy-1,4-benzoquinone: formed by the reaction of benzoquinone with hydrogen peroxide; structure given in first source. hydroxyquinone : Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group.. 2-hydroxy-1,4-benzoquinone : The simplest member of the class of 2-hydroxy-1,4-benzoquinones, that is 1,4-benzoquinone in which a single hydrogen is replaced by a hydroxy group.		2.0210monohydroxy-1,4-benzoquinonesmouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials