Page last updated: 2024-12-06

2-imidazoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-Imidazoline is a heterocyclic compound with a five-membered ring containing two nitrogen atoms. It is a basic compound and can form salts. 2-Imidazolines are of interest in medicinal chemistry and organic synthesis. They are known to exhibit various pharmacological activities, including antihypertensive, anti-inflammatory, and antimicrobial effects. Their importance lies in their potential to serve as building blocks for various drugs and bioactive molecules. Research on 2-imidazolines focuses on exploring their synthesis, structure-activity relationships, and biological applications. Several synthetic routes have been developed for the synthesis of 2-imidazolines, often involving ring-closing reactions of appropriate precursors.'

2-imidazoline: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

imidazoline : An imidazoline compound having the double bond at the 2-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID68156
CHEBI ID53094
MeSH IDM0068147

Synonyms (20)

Synonym
2-imidazoline
imidazoline
4,5-dihydro-1h-imidazole
CHEBI:53094
504-75-6
AKOS006351680
1h-imidazole, 4,5-dihydro-
unii-d36r5ylk6r
d36r5ylk6r ,
einecs 207-999-4
1h-imidazole, dihydro-
28299-33-4
MTNDZQHUAFNZQY-UHFFFAOYSA-N
DTXSID2060127
.delta.2-imidazoline
4,5-dihydroimidazole
corban 210ws
STL453690
Q419555
EN300-202371

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The lead compound demonstrated very good oral bioavailability in mice, slow metabolic degradation, modest distribution into the brain and a remarkable anti-inflammatory efficacy in carrageenan-induced mouse paw edema model."( Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.
Gavalas, A; Geronikaki, A; Hammock, B; Hwang, SH; Iurchenko, V; Ivanenkov, Y; Krasavin, M; Morisseau, C; Mujumdar, P; Sarnpitak, P; Zozulya, S, 2014
)
0.64
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
imidazolinesDiazoline compounds having the nitrogen atoms at the 1- and 3-positions and a double bond at an unspecified position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (49)

TimeframeStudies, This Drug (%)All Drugs %
pre-199026 (53.06)18.7374
1990's0 (0.00)18.2507
2000's8 (16.33)29.6817
2010's13 (26.53)24.3611
2020's2 (4.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.87 (24.57)
Research Supply Index4.01 (2.92)
Research Growth Index5.26 (4.65)
Search Engine Demand Index29.80 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (5.56%)6.00%
Case Studies1 (1.85%)4.05%
Observational0 (0.00%)0.25%
Other50 (92.59%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]